Setting description

Several treatments more effective in distinctive signatures: (Hormone therapies, TP53- & AR-); (Taxel therapies, TEfus+); (Carboplatin and Niraparib, DRD+)

Simulations setting

Survival curves (by signature)


PFS distributions (by signature)


Treatment effects (by signature)

signature var Other Hormone_therapies Taxel_therapies Carboplatin Niraparib
all param scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.114, shape = 1.05 scale = 0.124, shape = 1.05 scale = 0.124, shape = 1.05
summary mean = 8.8, median = 6.3 mean = 8.7, median = 6.3 mean = 8.6, median = 6.2 mean = 7.9, median = 5.7 mean = 7.9, median = 5.7
effect af = 1, hr = 1 af = 0.99, hr = 1.01 af = 0.98, hr = 1.02 af = 0.9, hr = 1.12 af = 0.9, hr = 1.12
TP53- & AR- param scale = 0.112, shape = 1.05 scale = 0.043, shape = 1.05 scale = 0.128, shape = 1.05 scale = 0.127, shape = 1.05 scale = 0.127, shape = 1.05
summary mean = 8.8, median = 6.3 mean = 22.6, median = 16.3 mean = 7.7, median = 5.5 mean = 7.7, median = 5.5 mean = 7.7, median = 5.5
effect af = 1, hr = 1 af = 2.58, hr = 0.37 af = 0.87, hr = 1.15 af = 0.88, hr = 1.15 af = 0.88, hr = 1.15
TP53+ param scale = 0.112, shape = 1.05 scale = 0.157, shape = 1.05 scale = 0.105, shape = 1.05 scale = 0.125, shape = 1.05 scale = 0.125, shape = 1.05
summary mean = 8.8, median = 6.3 mean = 6.3, median = 4.5 mean = 9.3, median = 6.7 mean = 7.8, median = 5.6 mean = 7.8, median = 5.6
effect af = 1, hr = 1 af = 0.71, hr = 1.43 af = 1.06, hr = 0.94 af = 0.89, hr = 1.13 af = 0.89, hr = 1.13
DRD+ param scale = 0.112, shape = 1.05 scale = 0.117, shape = 1.05 scale = 0.099, shape = 1.05 scale = 0.037, shape = 1.05 scale = 0.037, shape = 1.05
summary mean = 8.8, median = 6.3 mean = 8.4, median = 6 mean = 9.9, median = 7.1 mean = 26.6, median = 19.1 mean = 26.6, median = 19.1
effect af = 1, hr = 1 af = 0.95, hr = 1.05 af = 1.13, hr = 0.88 af = 3.03, hr = 0.31 af = 3.03, hr = 0.31
TEfus+ param scale = 0.112, shape = 1.05 scale = 0.127, shape = 1.05 scale = 0.039, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05
summary mean = 8.8, median = 6.3 mean = 7.7, median = 5.6 mean = 25, median = 18 mean = 8.7, median = 6.3 mean = 8.7, median = 6.3
effect af = 1, hr = 1 af = 0.88, hr = 1.14 af = 2.85, hr = 0.33 af = 0.99, hr = 1.01 af = 0.99, hr = 1.01



Survival curves (by subgroup)


PFS distributions (by subgroup)


Treatment effects (by subgroup)

subtype var Other Hormone_therapies Taxel_therapies Carboplatin Niraparib
—- param scale = 0.112, shape = 1.05 scale = 0.043, shape = 1.05 scale = 0.157, shape = 1.05 scale = 0.157, shape = 1.05 scale = 0.157, shape = 1.05
summary mean = 8.8, median = 6.3 mean = 22.6, median = 16.3 mean = 6.3, median = 4.5 mean = 6.3, median = 4.5 mean = 6.3, median = 4.5
effect af = 1, hr = 1 af = 2.58, hr = 0.37 af = 0.71, hr = 1.43 af = 0.71, hr = 1.43 af = 0.71, hr = 1.43
—+ param scale = 0.112, shape = 1.05 scale = 0.043, shape = 1.05 scale = 0.039, shape = 1.05 scale = 0.157, shape = 1.05 scale = 0.157, shape = 1.05
summary mean = 8.8, median = 6.3 mean = 22.6, median = 16.3 mean = 25, median = 18 mean = 6.3, median = 4.5 mean = 6.3, median = 4.5
effect af = 1, hr = 1 af = 2.58, hr = 0.37 af = 2.85, hr = 0.33 af = 0.71, hr = 1.43 af = 0.71, hr = 1.43
–+- param scale = 0.112, shape = 1.05 scale = 0.157, shape = 1.05 scale = 0.157, shape = 1.05 scale = 0.157, shape = 1.05 scale = 0.157, shape = 1.05
summary mean = 8.8, median = 6.3 mean = 6.3, median = 4.5 mean = 6.3, median = 4.5 mean = 6.3, median = 4.5 mean = 6.3, median = 4.5
effect af = 1, hr = 1 af = 0.71, hr = 1.43 af = 0.71, hr = 1.43 af = 0.71, hr = 1.43 af = 0.71, hr = 1.43
–++ param scale = 0.112, shape = 1.05 scale = 0.157, shape = 1.05 scale = 0.039, shape = 1.05 scale = 0.157, shape = 1.05 scale = 0.157, shape = 1.05
summary mean = 8.8, median = 6.3 mean = 6.3, median = 4.5 mean = 25, median = 18 mean = 6.3, median = 4.5 mean = 6.3, median = 4.5
effect af = 1, hr = 1 af = 0.71, hr = 1.43 af = 2.85, hr = 0.33 af = 0.71, hr = 1.43 af = 0.71, hr = 1.43
-+– param scale = 0.112, shape = 1.05 scale = 0.043, shape = 1.05 scale = 0.157, shape = 1.05 scale = 0.037, shape = 1.05 scale = 0.037, shape = 1.05
summary mean = 8.8, median = 6.3 mean = 22.6, median = 16.3 mean = 6.3, median = 4.5 mean = 26.6, median = 19.1 mean = 26.6, median = 19.1
effect af = 1, hr = 1 af = 2.58, hr = 0.37 af = 0.71, hr = 1.43 af = 3.03, hr = 0.31 af = 3.03, hr = 0.31
-+-+ param scale = 0.112, shape = 1.05 scale = 0.043, shape = 1.05 scale = 0.039, shape = 1.05 scale = 0.037, shape = 1.05 scale = 0.037, shape = 1.05
summary mean = 8.8, median = 6.3 mean = 22.6, median = 16.3 mean = 25, median = 18 mean = 26.6, median = 19.1 mean = 26.6, median = 19.1
effect af = 1, hr = 1 af = 2.58, hr = 0.37 af = 2.85, hr = 0.33 af = 3.03, hr = 0.31 af = 3.03, hr = 0.31
-++- param scale = 0.112, shape = 1.05 scale = 0.157, shape = 1.05 scale = 0.157, shape = 1.05 scale = 0.037, shape = 1.05 scale = 0.037, shape = 1.05
summary mean = 8.8, median = 6.3 mean = 6.3, median = 4.5 mean = 6.3, median = 4.5 mean = 26.6, median = 19.1 mean = 26.6, median = 19.1
effect af = 1, hr = 1 af = 0.71, hr = 1.43 af = 0.71, hr = 1.43 af = 3.03, hr = 0.31 af = 3.03, hr = 0.31
-+++ param scale = 0.112, shape = 1.05 scale = 0.157, shape = 1.05 scale = 0.039, shape = 1.05 scale = 0.037, shape = 1.05 scale = 0.037, shape = 1.05
summary mean = 8.8, median = 6.3 mean = 6.3, median = 4.5 mean = 25, median = 18 mean = 26.6, median = 19.1 mean = 26.6, median = 19.1
effect af = 1, hr = 1 af = 0.71, hr = 1.43 af = 2.85, hr = 0.33 af = 3.03, hr = 0.31 af = 3.03, hr = 0.31
+— param scale = 0.112, shape = 1.05 scale = 0.157, shape = 1.05 scale = 0.157, shape = 1.05 scale = 0.157, shape = 1.05 scale = 0.157, shape = 1.05
summary mean = 8.8, median = 6.3 mean = 6.3, median = 4.5 mean = 6.3, median = 4.5 mean = 6.3, median = 4.5 mean = 6.3, median = 4.5
effect af = 1, hr = 1 af = 0.71, hr = 1.43 af = 0.71, hr = 1.43 af = 0.71, hr = 1.43 af = 0.71, hr = 1.43
+–+ param scale = 0.112, shape = 1.05 scale = 0.157, shape = 1.05 scale = 0.039, shape = 1.05 scale = 0.157, shape = 1.05 scale = 0.157, shape = 1.05
summary mean = 8.8, median = 6.3 mean = 6.3, median = 4.5 mean = 25, median = 18 mean = 6.3, median = 4.5 mean = 6.3, median = 4.5
effect af = 1, hr = 1 af = 0.71, hr = 1.43 af = 2.85, hr = 0.33 af = 0.71, hr = 1.43 af = 0.71, hr = 1.43
+-+- param scale = 0.112, shape = 1.05 scale = 0.157, shape = 1.05 scale = 0.157, shape = 1.05 scale = 0.157, shape = 1.05 scale = 0.157, shape = 1.05
summary mean = 8.8, median = 6.3 mean = 6.3, median = 4.5 mean = 6.3, median = 4.5 mean = 6.3, median = 4.5 mean = 6.3, median = 4.5
effect af = 1, hr = 1 af = 0.71, hr = 1.43 af = 0.71, hr = 1.43 af = 0.71, hr = 1.43 af = 0.71, hr = 1.43
+-++ param scale = 0.112, shape = 1.05 scale = 0.157, shape = 1.05 scale = 0.039, shape = 1.05 scale = 0.157, shape = 1.05 scale = 0.157, shape = 1.05
summary mean = 8.8, median = 6.3 mean = 6.3, median = 4.5 mean = 25, median = 18 mean = 6.3, median = 4.5 mean = 6.3, median = 4.5
effect af = 1, hr = 1 af = 0.71, hr = 1.43 af = 2.85, hr = 0.33 af = 0.71, hr = 1.43 af = 0.71, hr = 1.43
++– param scale = 0.112, shape = 1.05 scale = 0.157, shape = 1.05 scale = 0.157, shape = 1.05 scale = 0.037, shape = 1.05 scale = 0.037, shape = 1.05
summary mean = 8.8, median = 6.3 mean = 6.3, median = 4.5 mean = 6.3, median = 4.5 mean = 26.6, median = 19.1 mean = 26.6, median = 19.1
effect af = 1, hr = 1 af = 0.71, hr = 1.43 af = 0.71, hr = 1.43 af = 3.03, hr = 0.31 af = 3.03, hr = 0.31
++-+ param scale = 0.112, shape = 1.05 scale = 0.157, shape = 1.05 scale = 0.039, shape = 1.05 scale = 0.037, shape = 1.05 scale = 0.037, shape = 1.05
summary mean = 8.8, median = 6.3 mean = 6.3, median = 4.5 mean = 25, median = 18 mean = 26.6, median = 19.1 mean = 26.6, median = 19.1
effect af = 1, hr = 1 af = 0.71, hr = 1.43 af = 2.85, hr = 0.33 af = 3.03, hr = 0.31 af = 3.03, hr = 0.31
+++- param scale = 0.112, shape = 1.05 scale = 0.157, shape = 1.05 scale = 0.157, shape = 1.05 scale = 0.037, shape = 1.05 scale = 0.037, shape = 1.05
summary mean = 8.8, median = 6.3 mean = 6.3, median = 4.5 mean = 6.3, median = 4.5 mean = 26.6, median = 19.1 mean = 26.6, median = 19.1
effect af = 1, hr = 1 af = 0.71, hr = 1.43 af = 0.71, hr = 1.43 af = 3.03, hr = 0.31 af = 3.03, hr = 0.31
++++ param scale = 0.112, shape = 1.05 scale = 0.157, shape = 1.05 scale = 0.039, shape = 1.05 scale = 0.037, shape = 1.05 scale = 0.037, shape = 1.05
summary mean = 8.8, median = 6.3 mean = 6.3, median = 4.5 mean = 25, median = 18 mean = 26.6, median = 19.1 mean = 26.6, median = 19.1
effect af = 1, hr = 1 af = 0.71, hr = 1.43 af = 2.85, hr = 0.33 af = 3.03, hr = 0.31 af = 3.03, hr = 0.31

Errors and power


graduation (counts and proportions):
Hormone_therapies Taxel_therapies Carboplatin Niraparib
all 11 1 4 5
TP53- & AR- 291 1 1 1
TP53+ 2 27 5 8
DRD+ 0 0 89 93
TEfus+ 0 166 2 0
Hormone_therapies Taxel_therapies Carboplatin Niraparib
all 0.022 0.002 0.008 0.010
TP53- & AR- 0.582 0.002 0.002 0.002
TP53+ 0.004 0.054 0.010 0.016
DRD+ 0.000 0.000 0.178 0.186
TEfus+ 0.000 0.332 0.004 0.000
futility (counts and proportions):
Hormone_therapies Taxel_therapies Carboplatin Niraparib
all 4 0 0 1
TP53- & AR- 1 84 71 79
TP53+ 256 1 0 3
DRD+ 51 8 1 0
TEfus+ 112 0 8 8
Hormone_therapies Taxel_therapies Carboplatin Niraparib
all 0.008 0.000 0.000 0.002
TP53- & AR- 0.002 0.168 0.142 0.158
TP53+ 0.512 0.002 0.000 0.006
DRD+ 0.102 0.016 0.002 0.000
TEfus+ 0.224 0.000 0.016 0.016
max sample size (counts and proportions):
Hormone_therapies Taxel_therapies Carboplatin Niraparib
all 0 0 0 0
TP53- & AR- 143 11 33 40
TP53+ 0 42 14 8
DRD+ 0 0 0 0
TEfus+ 0 28 3 0
Hormone_therapies Taxel_therapies Carboplatin Niraparib
all 0.000 0.000 0.000 0.000
TP53- & AR- 0.286 0.022 0.066 0.080
TP53+ 0.000 0.084 0.028 0.016
DRD+ 0.000 0.000 0.000 0.000
TEfus+ 0.000 0.056 0.006 0.000


Errors & power

The overall error was 0.082.
The corresponding errors separate for the different treatments were:

Hormone_therapies   Taxel_therapies       Carboplatin         Niraparib 
            0.020             0.034             0.014             0.016 

The overall power was 0.808.
The corresponding power separate for the different treatments were:

Hormone_therapies   Taxel_therapies       Carboplatin         Niraparib 
            0.582             0.332             0.178             0.186 

Median results at the end of the trial

By signature:
signature var Control Hormone_therapies Taxel_therapies Carboplatin Niraparib
all graduation 0 11 1 4 5
futility 0 4 0 0 1
max_n 0 0 0 0 0
n 446 (420, 478) 160 (85, 246) 195 (111, 262) 176 (130, 258) 173 (121, 255)
n_unique 408 (385, 439) 148 (77, 233) 178 (98, 242) 159 (117, 242) 158 (112, 237)
time_trial 36 (36, 36) 36 (36, 36) 36 (36, 36) 36 (36, 36) 36 (36, 36)
time_stop NA (NA, NA) 5 (3, 7) 5 (5, 5) 6 (6, 7) 8 (5, 11)
post_p NA (NA, NA) 0.95 (0.17, 1) 0.99 (0.49, 1) 0.92 (0.25, 1) 0.9 (0.24, 1)
rate 0.094 (0.087, 0.101) 0.077 (0.061, 0.102) 0.072 (0.06, 0.091) 0.079 (0.065, 0.098) 0.08 (0.066, 0.098)
TP53- & AR- graduation 0 291 1 1 1
futility 0 1 84 71 79
max_n 0 143 11 33 40
n 193 (173, 213) 66 (26, 153) 44 (25, 117) 51 (28, 138) 51 (28, 141)
n_unique 178 (160, 200) 64 (25, 146) 40 (21, 111) 46 (26, 132) 46 (25, 134)
time_trial 36 (36, 36) 20 (8, 36) 36 (23, 36) 36 (21, 36) 36 (19, 36)
time_stop NA (NA, NA) 10 (7, 23) 22 (13, 32) 16 (11, 28) 17 (14, 25)
post_p NA (NA, NA) 1 (0.97, 1) 0.32 (0.01, 0.9) 0.5 (0, 0.96) 0.41 (0, 0.93)
rate 0.075 (0.066, 0.085) 0.042 (0.034, 0.051) 0.083 (0.055, 0.12) 0.075 (0.052, 0.113) 0.078 (0.052, 0.116)
TP53+ graduation 0 2 27 5 8
futility 0 256 1 0 3
max_n 0 0 42 14 8
n 193 (173, 216) 56 (28, 93) 110 (52, 145) 84 (57, 123) 82 (53, 120)
n_unique 176 (156, 197) 51 (26, 86) 100 (48, 135) 77 (51, 115) 75 (48, 112)
time_trial 36 (36, 36) 34 (15, 36) 36 (36, 36) 36 (36, 36) 36 (36, 36)
time_stop NA (NA, NA) 22 (13, 32) 10 (8, 15) 16 (9, 19) 14 (9, 18)
post_p NA (NA, NA) 0.02 (0, 0.14) 1 (0.9, 1) 0.95 (0.54, 1) 0.95 (0.54, 1)
rate 0.113 (0.102, 0.126) 0.161 (0.137, 0.198) 0.067 (0.051, 0.089) 0.085 (0.065, 0.109) 0.085 (0.063, 0.108)
DRD+ graduation 0 0 0 89 93
futility 0 51 8 1 0
max_n 0 0 0 0 0
n 111 (96, 128) 27 (17, 44) 38 (21, 57) 79 (50, 101) 76 (46, 99)
n_unique 100 (86, 116) 24 (15, 40) 34 (19, 52) 72 (45, 93) 70 (42, 91)
time_trial 36 (36, 36) 36 (35, 36) 36 (36, 36) 36 (26, 36) 36 (27, 36)
time_stop NA (NA, NA) 28 (21, 34) 26 (20, 33) 23 (13, 35) 25 (12, 34)
post_p NA (NA, NA) 0.23 (0.02, 0.79) 0.76 (0.22, 0.98) 1 (1, 1) 1 (1, 1)
rate 0.091 (0.078, 0.107) 0.103 (0.069, 0.159) 0.07 (0.05, 0.099) 0.036 (0.029, 0.044) 0.036 (0.029, 0.045)
TEfus+ graduation 0 0 166 2 0
futility 0 112 0 8 8
max_n 0 0 28 3 0
n 161 (143, 179) 39 (24, 61) 114 (31, 144) 63 (43, 102) 62 (41, 95)
n_unique 147 (130, 164) 35 (22, 56) 104 (28, 133) 58 (39, 95) 57 (38, 87)
time_trial 36 (36, 36) 36 (21, 36) 36 (11, 36) 36 (36, 36) 36 (36, 36)
time_stop NA (NA, NA) 22 (15, 32) 14 (9, 33) 18 (12, 27) 14 (11, 24)
post_p NA (NA, NA) 0.08 (0, 0.55) 1 (0.99, 1) 0.69 (0.12, 0.96) 0.7 (0.15, 0.97)
rate 0.076 (0.066, 0.087) 0.101 (0.075, 0.138) 0.038 (0.031, 0.046) 0.068 (0.052, 0.088) 0.067 (0.05, 0.09)


By subgroup combinations:
subtype var Control Hormone_therapies Taxel_therapies Carboplatin Niraparib
—- graduation 0 306 86 76 86
futility 0 0 0 0 0
max_n 0 143 11 33 40
n 129 (114, 144) 53 (21, 124) 15 (8, 85) 15 (7, 95) 16 (7, 99)
n_unique 120 (106, 136) 50 (20, 120) 13 (7, 82) 13 (6, 90) 14 (6, 94)
post_p NA (NA, NA) 1 (0.99, 1) 0.04 (0, 0.15) 0.04 (0, 0.13) 0.03 (0, 0.15)
rate 0.083 (0.072, 0.097) 0.042 (0.033, 0.052) 0.165 (0.128, 0.268) 0.17 (0.132, 0.299) 0.169 (0.132, 0.281)
—+ graduation 0 344 237 83 92
futility 0 0 0 0 0
max_n 0 139 37 34 40
n 22 (15, 29) 5 (2, 18) 14 (3, 25) 6 (3, 15) 5 (2, 14)
n_unique 20 (14, 27) 5 (2, 17) 13 (3, 23) 5 (2, 14) 5 (2, 13)
post_p NA (NA, NA) 0.68 (0.33, 0.92) 0.81 (0.39, 0.97) 0.14 (0.03, 0.3) 0.14 (0.03, 0.33)
rate 0.053 (0.033, 0.081) 0.044 (0.021, 0.097) 0.039 (0.021, 0.081) 0.176 (0.108, 0.36) 0.176 (0.104, 0.414)
–+- graduation 0 273 29 9 15
futility 0 0 0 0 0
max_n 0 0 42 14 8
n 65 (52, 80) 20 (8, 53) 24 (7, 58) 23 (6, 56) 22 (6, 55)
n_unique 60 (47, 74) 19 (8, 49) 22 (7, 55) 21 (5, 53) 20 (6, 52)
post_p NA (NA, NA) 0.32 (0.09, 0.74) 0.34 (0.08, 0.79) 0.29 (0.08, 0.75) 0.31 (0.08, 0.73)
rate 0.145 (0.121, 0.172) 0.169 (0.132, 0.263) 0.165 (0.13, 0.285) 0.172 (0.129, 0.315) 0.173 (0.133, 0.301)
–++ graduation 0 320 183 19 23
futility 0 0 0 0 0
max_n 0 0 65 16 8
n 48 (38, 58) 7 (4, 15) 41 (13, 54) 8 (4, 33) 7 (4, 25)
n_unique 44 (35, 54) 6 (3, 14) 38 (12, 50) 7 (3, 31) 6 (3, 23)
post_p NA (NA, NA) 0.15 (0.05, 0.36) 1 (0.96, 1) 0.14 (0.03, 0.35) 0.14 (0.03, 0.32)
rate 0.088 (0.068, 0.111) 0.172 (0.116, 0.304) 0.038 (0.027, 0.053) 0.169 (0.121, 0.358) 0.182 (0.122, 0.333)
-+– graduation 0 325 91 160 169
futility 0 0 0 0 0
max_n 0 139 11 31 38
n 21 (14, 27) 3 (0, 12) 4 (2, 9) 14 (4, 24) 13 (4, 23)
n_unique 19 (12, 25) 3 (0, 12) 4 (2, 8) 13 (4, 23) 12 (3, 21)
post_p NA (NA, NA) 0.68 (0.36, 0.92) 0.18 (0.07, 0.36) 0.88 (0.5, 0.99) 0.84 (0.47, 0.98)
rate 0.084 (0.058, 0.124) 0.044 (0.016, 0.104) 0.185 (0.106, 0.451) 0.036 (0.02, 0.065) 0.038 (0.021, 0.074)
-+-+ graduation 0 352 242 166 175
futility 0 0 0 0 0
max_n 0 135 37 32 38
n 20 (15, 28) 3 (0, 11) 7 (2, 18) 12 (4, 22) 12 (4, 22)
n_unique 19 (13, 25) 3 (0, 11) 6 (1, 16) 11 (4, 20) 11 (4, 20)
post_p NA (NA, NA) 0.5 (0.26, 0.77) 0.55 (0.24, 0.84) 0.62 (0.31, 0.88) 0.62 (0.27, 0.9)
rate 0.053 (0.032, 0.081) 0.045 (0.017, 0.131) 0.042 (0.018, 0.095) 0.038 (0.022, 0.067) 0.037 (0.02, 0.074)
-++- graduation 0 297 37 95 103
futility 0 0 0 0 0
max_n 0 0 42 13 8
n 11 (7, 16) 3 (1, 6) 3 (1, 6) 8 (3, 15) 9 (3, 15)
n_unique 10 (6, 15) 3 (0, 5) 3 (1, 6) 8 (2, 14) 8 (2, 14)
post_p NA (NA, NA) 0.34 (0.18, 0.55) 0.32 (0.18, 0.53) 0.9 (0.65, 0.99) 0.9 (0.61, 0.99)
rate 0.149 (0.098, 0.23) 0.193 (0.092, 0.611) 0.188 (0.093, 0.53) 0.036 (0.016, 0.075) 0.037 (0.016, 0.083)
-+++ graduation 0 330 190 104 111
futility 0 0 0 0 0
max_n 0 0 65 15 8
n 12 (7, 17) 3 (1, 5) 4 (1, 10) 8 (3, 14) 8 (3, 13)
n_unique 11 (6, 16) 2 (1, 5) 4 (0, 10) 7 (3, 13) 7 (2, 12)
post_p NA (NA, NA) 0.28 (0.16, 0.42) 0.65 (0.39, 0.89) 0.72 (0.45, 0.92) 0.71 (0.43, 0.92)
rate 0.088 (0.051, 0.151) 0.188 (0.093, 0.614) 0.04 (0.007, 0.12) 0.037 (0.018, 0.074) 0.039 (0.017, 0.083)
+— graduation 0 15 1 4 6
futility 0 0 0 0 0
max_n 0 0 0 0 0
n 20 (14, 28) 8 (3, 18) 9 (4, 20) 8 (3, 18) 8 (3, 17)
n_unique 19 (13, 26) 7 (2, 16) 9 (4, 18) 7 (2, 16) 7 (2, 16)
post_p NA (NA, NA) 0.37 (0.15, 0.79) 0.39 (0.14, 0.78) 0.41 (0.16, 0.81) 0.42 (0.18, 0.81)
rate 0.147 (0.108, 0.205) 0.182 (0.113, 0.43) 0.177 (0.122, 0.365) 0.174 (0.11, 0.391) 0.178 (0.108, 0.407)
+–+ graduation 0 127 167 14 14
futility 0 0 0 0 0
max_n 0 0 28 3 0
n 18 (11, 24) 4 (2, 10) 14 (4, 22) 5 (2, 11) 5 (2, 11)
n_unique 16 (10, 22) 4 (2, 9) 13 (4, 20) 4 (2, 10) 4 (2, 10)
post_p NA (NA, NA) 0.25 (0.1, 0.51) 0.95 (0.72, 1) 0.25 (0.11, 0.48) 0.25 (0.11, 0.51)
rate 0.087 (0.059, 0.133) 0.192 (0.101, 0.496) 0.039 (0.02, 0.066) 0.181 (0.1, 0.449) 0.176 (0.103, 0.502)
+-+- graduation 0 273 29 9 15
futility 0 0 0 0 0
max_n 0 0 42 14 8
n 16 (11, 22) 6 (1, 15) 7 (3, 15) 7 (3, 15) 7 (3, 15)
n_unique 15 (9, 21) 5 (1, 14) 6 (3, 14) 6 (2, 14) 6 (2, 14)
post_p NA (NA, NA) 0.41 (0.2, 0.78) 0.39 (0.16, 0.77) 0.41 (0.18, 0.8) 0.42 (0.19, 0.79)
rate 0.146 (0.105, 0.206) 0.183 (0.113, 0.441) 0.186 (0.116, 0.416) 0.178 (0.109, 0.452) 0.177 (0.107, 0.41)
+-++ graduation 0 320 183 19 23
futility 0 0 0 0 0
max_n 0 0 65 16 8
n 17 (12, 23) 4 (2, 9) 13 (3, 22) 5 (2, 12) 5 (2, 11)
n_unique 16 (10, 21) 3 (1, 8) 12 (3, 20) 4 (2, 11) 4 (2, 10)
post_p NA (NA, NA) 0.27 (0.12, 0.5) 0.95 (0.72, 1) 0.25 (0.11, 0.49) 0.26 (0.11, 0.48)
rate 0.087 (0.056, 0.132) 0.176 (0.101, 0.441) 0.037 (0.019, 0.069) 0.17 (0.099, 0.384) 0.176 (0.102, 0.403)
++– graduation 0 66 9 94 99
futility 0 0 0 0 0
max_n 0 0 0 0 0
n 11 (7, 17) 3 (1, 6) 3 (1, 7) 8 (3, 15) 8 (3, 15)
n_unique 10 (6, 15) 3 (1, 6) 3 (1, 6) 8 (3, 13) 8 (3, 14)
post_p NA (NA, NA) 0.32 (0.16, 0.53) 0.32 (0.18, 0.54) 0.9 (0.57, 0.99) 0.91 (0.58, 0.99)
rate 0.153 (0.095, 0.232) 0.195 (0.094, 0.565) 0.187 (0.095, 0.58) 0.037 (0.017, 0.091) 0.037 (0.017, 0.084)
++-+ graduation 0 158 174 103 107
futility 0 0 0 0 0
max_n 0 0 28 3 0
n 11 (7, 16) 3 (1, 6) 4 (1, 10) 8 (3, 14) 8 (3, 13)
n_unique 10 (6, 15) 3 (1, 5) 4 (1, 9) 7 (3, 13) 7 (2, 13)
post_p NA (NA, NA) 0.27 (0.12, 0.42) 0.67 (0.38, 0.9) 0.73 (0.42, 0.93) 0.74 (0.38, 0.94)
rate 0.088 (0.054, 0.154) 0.184 (0.093, 0.455) 0.04 (0.014, 0.106) 0.039 (0.016, 0.086) 0.038 (0.016, 0.088)
+++- graduation 0 297 37 95 103
futility 0 0 0 0 0
max_n 0 0 42 13 8
n 12 (7, 16) 3 (1, 6) 3 (1, 6) 8 (3, 15) 8 (3, 14)
n_unique 10 (6, 15) 2 (1, 5) 3 (1, 6) 8 (2, 13) 8 (3, 13)
post_p NA (NA, NA) 0.33 (0.17, 0.55) 0.32 (0.17, 0.53) 0.89 (0.58, 0.99) 0.9 (0.59, 0.99)
rate 0.146 (0.097, 0.226) 0.201 (0.09, 0.553) 0.183 (0.095, 0.501) 0.039 (0.017, 0.083) 0.037 (0.015, 0.083)
++++ graduation 0 330 190 104 111
futility 0 0 0 0 0
max_n 0 0 65 15 8
n 11 (7, 16) 3 (1, 5) 4 (0, 10) 8 (3, 14) 7 (2, 14)
n_unique 10 (6, 15) 3 (1, 5) 4 (0, 10) 7 (2, 13) 7 (2, 13)
post_p NA (NA, NA) 0.28 (0.14, 0.42) 0.66 (0.38, 0.87) 0.74 (0.41, 0.94) 0.73 (0.4, 0.93)
rate 0.089 (0.054, 0.154) 0.183 (0.098, 0.58) 0.041 (0.009, 0.114) 0.036 (0.016, 0.08) 0.037 (0.015, 0.09)

Median results over time

Signatures:

Posterior probabilities

Randomization probabilities

PFS rates


Subgroup combinations:

Posterior probabilities

Randomization probabilities

PFS rates

Median results at stop

By signature

Graduation:
signature var Hormone_therapies Taxel_therapies Carboplatin Niraparib
all count 11 1 4 5
time_stop 5 (4, 7) 5 (5, 5) 6 (6, 7) 6 (5, 10)
n_trt 29 (25, 45) 25 (25, 25) 27 (26, 28) 28 (26, 48)
n_control 58 (48, 73) 57 (57, 57) 70 (61, 96) 65 (52, 102)
post_p 0.92 (0.86, 0.97) 0.9 (0.9, 0.9) 0.99 (0.98, 1) 0.96 (0.95, 0.98)
order 1 (1, 1) 1 (1, 1) 1 (1, 1) 1 (1, 1)
TP53- & AR- count 291 1 1 1
time_stop 10 (7, 23) 15 (15, 15) 12 (12, 12) 11 (11, 11)
n_trt 35 (26, 95) 32 (32, 32) 35 (35, 35) 29 (29, 29)
n_control 44 (30, 107) 58 (58, 58) 52 (52, 52) 46 (46, 46)
post_p 0.95 (0.87, 1) 0.9 (0.9, 0.9) 0.86 (0.86, 0.86) 0.89 (0.89, 0.89)
order 1 (1, 2) 3 (3, 3) 3 (3, 3) 2 (2, 2)
TP53+ count 2 27 5 8
time_stop 11 (10, 12) 10 (8, 15) 16 (9, 19) 15 (9, 20)
n_trt 30 (26, 33) 29 (26, 44) 29 (25, 47) 32 (28, 54)
n_control 46 (41, 51) 42 (33, 65) 59 (47, 74) 62 (37, 97)
post_p 0.9 (0.89, 0.92) 0.98 (0.92, 1) 0.98 (0.96, 0.98) 0.96 (0.91, 1)
order 2 (2, 2) 1 (1, 2) 1 (1, 2) 1 (1, 3.3)
DRD+ count 89 93
time_stop 23 (13, 35) 25 (12, 34)
n_trt 56 (26, 91) 57 (26, 85)
n_control 65 (27, 105) 73 (28, 108)
post_p 1 (0.98, 1) 1 (0.98, 1)
order 2 (1, 3) 2 (1, 3)
TEfus+ count 166 2
time_stop 14 (9, 33) 16 (10, 21)
n_trt 43 (26, 110) 40 (30, 51)
n_control 57 (30, 140) 62 (44, 79)
post_p 0.99 (0.92, 1) 0.98 (0.97, 1)
order 2 (1, 2) 1 (1, 1)
Futility:
signature var Hormone_therapies Taxel_therapies Carboplatin Niraparib
all count 4 1
time_stop 4 (3, 6) 12 (12, 12)
n_trt 30 (25, 44) 51 (51, 51)
n_control 52 (36, 62) 129 (129, 129)
post_p 0.03 (0, 0.22) 0.06 (0.06, 0.06)
order 1 (1, 1) 1 (1, 1)
TP53- & AR- count 1 84 71 79
time_stop 13 (13, 13) 22 (13, 32) 17 (11, 28) 17 (14, 25)
n_trt 46 (46, 46) 29 (25, 48) 30 (25, 48) 30 (25, 54)
n_control 58 (58, 58) 101 (56, 161) 74 (51, 137) 80 (58, 128)
post_p 0.16 (0.16, 0.16) 0.08 (0.01, 0.21) 0.14 (0.02, 0.25) 0.12 (0.01, 0.27)
order 1 (1, 1) 1 (1, 2) 1 (1, 2) 1 (1, 2.2)
TP53+ count 256 1 3
time_stop 22 (13, 32) 10 (10, 10) 14 (12, 17)
n_trt 43 (27, 68) 34 (34, 34) 32 (27, 34)
n_control 107 (58, 170) 36 (36, 36) 79 (57, 81)
post_p 0.02 (0, 0.1) 0.24 (0.24, 0.24) 0.1 (0.08, 0.14)
order 1 (1, 2) 1 (1, 1) 2 (1.2, 2)
DRD+ count 51 8 1
time_stop 28 (21, 34) 26 (20, 33) 14 (14, 14)
n_trt 28 (25, 40) 28 (25, 44) 26 (26, 26)
n_control 79 (53, 105) 72 (50, 115) 33 (33, 33)
post_p 0.04 (0.01, 0.15) 0.1 (0.02, 0.23) 0.13 (0.13, 0.13)
order 2 (1, 3) 2 (1, 3) 1 (1, 1)
TEfus+ count 112 8 8
time_stop 22 (15, 32) 18 (12, 29) 14 (11, 24)
n_trt 33 (25, 55) 34 (30, 41) 30 (27, 45)
n_control 86 (54, 142) 76 (47, 127) 45 (33, 106)
post_p 0.03 (0, 0.1) 0.13 (0.07, 0.18) 0.17 (0.06, 0.21)
order 2 (1, 3) 1 (1, 2) 1 (1, 2)


By subgroup combinations

Graduation:
signature treatment var —- —+ –+- –++ -+– -+-+ -++- -+++ +— +–+ +-+- +-++ ++– ++-+ +++- ++++
all Hormone_therapies count 11 11 11 11 11 11 11 11 11 11 11 11 11 11 11 11
time 5 (4, 7) 5 (4, 7) 5 (4, 7) 5 (4, 7) 5 (4, 7) 5 (4, 7) 5 (4, 7) 5 (4, 7) 5 (4, 7) 5 (4, 7) 5 (4, 7) 5 (4, 7) 5 (4, 7) 5 (4, 7) 5 (4, 7) 5 (4, 7)
n 15 (13, 19) 2 (1, 5) 8 (4, 9) 1 (0, 4) 0 (0, 0) 0 (0, 1) 0 (0, 1) 0 (0, 0) 1 (0, 2) 1 (0, 2) 1 (0, 2) 0 (0, 3) 0 (0, 1) 0 (0, 0) 0 (0, 1) 0 (0, 1)
post_p 0.81 (0.7, 0.89) 0.53 (0.52, 0.6) 0.61 (0.52, 0.7) 0.52 (0.51, 0.55) 0.53 (0.53, 0.53) 0.53 (0.52, 0.55) 0.53 (0.52, 0.55) NA (NA, NA) 0.55 (0.52, 0.66) 0.54 (0.52, 0.57) 0.54 (0.51, 0.6) 0.54 (0.54, 0.57) 0.52 (0.51, 0.54) NA (NA, NA) 0.52 (0.51, 0.52) NA (NA, NA)
r_prob 0.44 (0.44, 0.44) 0.35 (0.35, 0.35) 0.33 (0.33, 0.33) 0.18 (0.18, 0.18) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0.18 (0.18, 0.18) 0.18 (0.18, 0.18) 0.12 (0.12, 0.12) 0.12 (0.12, 0.12) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
rate 0.012 (0, 0.033) 0 (0, 0) 0 (0, 0.092) 0 (0, 0.08) 0 (0, 0) 0 (0, 0) 0 (0, 0) NA (NA, NA) 0 (0, 0.127) 0 (0, 0.101) 0 (0, 0) 0 (0, 0) 0 (0, 0) NA (NA, NA) 0 (0, 0) 0.603 (0.121, 1.085)
Taxel_therapies count 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1
time 5 (5, 5) 5 (5, 5) 5 (5, 5) 5 (5, 5) 5 (5, 5) 5 (5, 5) 5 (5, 5) 5 (5, 5) 5 (5, 5) 5 (5, 5) 5 (5, 5) 5 (5, 5) 5 (5, 5) 5 (5, 5) 5 (5, 5) 5 (5, 5)
n 9 (9, 9) 1 (1, 1) 0 (0, 0) 3 (3, 3) 0 (0, 0) 0 (0, 0) 0 (0, 0) 1 (1, 1) 4 (4, 4) 1 (1, 1) 0 (0, 0) 6 (6, 6) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
post_p 0.5 (0.5, 0.5) 0.53 (0.53, 0.53) NA (NA, NA) 0.6 (0.6, 0.6) NA (NA, NA) NA (NA, NA) NA (NA, NA) 0.51 (0.51, 0.51) 0.59 (0.59, 0.59) 0.55 (0.55, 0.55) NA (NA, NA) 0.62 (0.62, 0.62) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA)
r_prob 0.11 (0.11, 0.11) 0.29 (0.29, 0.29) 0.17 (0.17, 0.17) 0.41 (0.41, 0.41) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0.41 (0.41, 0.41) 0.41 (0.41, 0.41) 0.37 (0.37, 0.37) 0.37 (0.37, 0.37) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
rate 0.102 (0.102, 0.102) 0 (0, 0) NA (NA, NA) 0 (0, 0) NA (NA, NA) NA (NA, NA) NA (NA, NA) 0 (0, 0) 0.081 (0.081, 0.081) 0 (0, 0) NA (NA, NA) 0 (0, 0) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA)
Carboplatin count 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4
time 6 (6, 7) 6 (6, 7) 6 (6, 7) 6 (6, 7) 6 (6, 7) 6 (6, 7) 6 (6, 7) 6 (6, 7) 6 (6, 7) 6 (6, 7) 6 (6, 7) 6 (6, 7) 6 (6, 7) 6 (6, 7) 6 (6, 7) 6 (6, 7)
n 3 (3, 3) 0 (0, 1) 4 (3, 5) 2 (0, 3) 2 (1, 3) 4 (2, 4) 2 (0, 3) 2 (1, 4) 1 (0, 1) 0 (0, 2) 2 (0, 2) 0 (0, 1) 2 (1, 3) 0 (0, 1) 1 (0, 2) 2 (0, 4)
post_p 0.61 (0.58, 0.65) 0.51 (0.51, 0.51) 0.59 (0.51, 0.75) 0.52 (0.52, 0.62) 0.53 (0.53, 0.58) 0.55 (0.52, 0.58) 0.6 (0.54, 0.66) 0.57 (0.53, 0.61) 0.58 (0.55, 0.59) 0.56 (0.55, 0.58) 0.57 (0.54, 0.61) 0.52 (0.51, 0.53) 0.53 (0.5, 0.56) 0.51 (0.51, 0.51) 0.54 (0.53, 0.56) 0.53 (0.53, 0.55)
r_prob 0 (0, 0) 0 (0, 0) 0.08 (0.08, 0.08) 0 (0, 0) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0 (0, 0) 0 (0, 0) 0.06 (0.06, 0.06) 0.06 (0.06, 0.06) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33)
rate 0 (0, 0) 0 (0, 0) 0.085 (0.019, 0.171) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
Niraparib count 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5
time 6 (5, 10) 6 (5, 10) 6 (5, 10) 6 (5, 10) 6 (5, 10) 6 (5, 10) 6 (5, 10) 6 (5, 10) 6 (5, 10) 6 (5, 10) 6 (5, 10) 6 (5, 10) 6 (5, 10) 6 (5, 10) 6 (5, 10) 6 (5, 10)
n 4 (1, 10) 2 (0, 2) 6 (3, 12) 1 (0, 2) 2 (0, 4) 2 (1, 7) 0 (0, 2) 0 (0, 3) 0 (0, 2) 0 (0, 2) 1 (0, 5) 0 (0, 0) 2 (0, 5) 0 (0, 2) 3 (1, 6) 3 (0, 5)
post_p 0.56 (0.53, 0.59) 0.52 (0.5, 0.55) 0.73 (0.6, 0.8) 0.52 (0.52, 0.53) 0.56 (0.52, 0.59) 0.52 (0.51, 0.58) 0.56 (0.56, 0.56) 0.63 (0.62, 0.64) 0.63 (0.6, 0.66) 0.61 (0.61, 0.61) 0.6 (0.58, 0.61) NA (NA, NA) 0.54 (0.51, 0.57) 0.55 (0.53, 0.57) 0.56 (0.52, 0.64) 0.53 (0.52, 0.53)
r_prob 0 (0, 0) 0 (0, 0) 0.08 (0.08, 0.08) 0 (0, 0) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0 (0, 0) 0 (0, 0) 0.06 (0.06, 0.06) 0.06 (0.06, 0.06) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33)
rate 0 (0, 0.099) 0 (0, 0) 0.072 (0, 0.118) 0 (0, 0) 0 (0, 0.089) 0 (0, 0.019) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0.077) NA (NA, NA) 0 (0, 0.024) 0 (0, 0) 0 (0, 0.052) 0 (0, 0)
TP53- & AR- Hormone_therapies count 291 291 291 291
time 10 (7, 23) 10 (7, 23) 10 (7, 23) 10 (7, 23)
n 28 (20, 75) 4 (2, 11) 2 (0, 6) 2 (0, 5)
post_p 0.95 (0.82, 1) 0.58 (0.51, 0.77) 0.56 (0.51, 0.76) 0.54 (0.51, 0.7)
r_prob 0.44 (0.44, 0.44) 0.35 (0.35, 0.35) 0 (0, 0) 0 (0, 0)
rate 0.038 (0.018, 0.054) 0 (0, 0.064) 0 (0, 0.053) 0 (0, 0.048)
Taxel_therapies count 1 1 1 1
time 15 (15, 15) 15 (15, 15) 15 (15, 15) 15 (15, 15)
n 25 (25, 25) 3 (3, 3) 1 (1, 1) 3 (3, 3)
post_p 0.72 (0.72, 0.72) 0.74 (0.74, 0.74) 0.57 (0.57, 0.57) 0.54 (0.54, 0.54)
r_prob 0.11 (0.11, 0.11) 0.29 (0.29, 0.29) 0 (0, 0) 0 (0, 0)
rate 0.066 (0.066, 0.066) 0.038 (0.038, 0.038) 0 (0, 0) 0 (0, 0)
Carboplatin count 1 1 1 1
time 12 (12, 12) 12 (12, 12) 12 (12, 12) 12 (12, 12)
n 21 (21, 21) 5 (5, 5) 7 (7, 7) 2 (2, 2)
post_p 0.7 (0.7, 0.7) 0.55 (0.55, 0.55) 0.72 (0.72, 0.72) 0.52 (0.52, 0.52)
r_prob 0 (0, 0) 0 (0, 0) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33)
rate 0.09 (0.09, 0.09) 0.077 (0.077, 0.077) 0.057 (0.057, 0.057) 0 (0, 0)
Niraparib count 1 1 1 1
time 11 (11, 11) 11 (11, 11) 11 (11, 11) 11 (11, 11)
n 18 (18, 18) 5 (5, 5) 3 (3, 3) 3 (3, 3)
post_p 0.81 (0.81, 0.81) 0.52 (0.52, 0.52) 0.58 (0.58, 0.58) 0.55 (0.55, 0.55)
r_prob 0 (0, 0) 0 (0, 0) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33)
rate 0.041 (0.041, 0.041) 0.096 (0.096, 0.096) 0.04 (0.04, 0.04) 0 (0, 0)
TP53+ Hormone_therapies count 2 2 2 2 2 2 2 2
time 11 (10, 12) 11 (10, 12) 11 (10, 12) 11 (10, 12) 11 (10, 12) 11 (10, 12) 11 (10, 12) 11 (10, 12)
n 17 (12, 22) 4 (4, 5) 0 (0, 1) 0 (0, 0) 2 (1, 4) 3 (2, 4) 0 (0, 1) 2 (1, 2)
post_p 0.84 (0.81, 0.88) 0.7 (0.67, 0.74) 0.54 (0.54, 0.54) NA (NA, NA) 0.76 (0.76, 0.76) 0.53 (0.52, 0.54) 0.5 (0.5, 0.5) 0.54 (0.52, 0.57)
r_prob 0.33 (0.33, 0.33) 0.18 (0.18, 0.18) 0 (0, 0) 0 (0, 0) 0.12 (0.12, 0.12) 0.12 (0.12, 0.12) 0 (0, 0) 0 (0, 0)
rate 0.069 (0.067, 0.072) 0.054 (0.043, 0.065) 0 (0, 0) NA (NA, NA) 0.036 (0.007, 0.065) 0.06 (0.012, 0.108) 0 (0, 0) 0 (0, 0)
Taxel_therapies count 27 27 27 27 27 27 27 27
time 10 (8, 15) 10 (8, 15) 10 (8, 15) 10 (8, 15) 10 (8, 15) 10 (8, 15) 10 (8, 15) 10 (8, 15)
n 9 (5, 14) 11 (8, 18) 0 (0, 2) 1 (0, 4) 3 (1, 5) 4 (2, 6) 0 (0, 2) 1 (0, 3)
post_p 0.75 (0.63, 0.84) 0.77 (0.71, 0.97) 0.53 (0.5, 0.6) 0.56 (0.52, 0.65) 0.54 (0.51, 0.68) 0.64 (0.52, 0.8) 0.54 (0.53, 0.59) 0.53 (0.51, 0.6)
r_prob 0.17 (0.17, 0.17) 0.41 (0.41, 0.41) 0 (0, 0) 0 (0, 0) 0.37 (0.37, 0.37) 0.37 (0.37, 0.37) 0 (0, 0) 0 (0, 0)
rate 0.089 (0.049, 0.135) 0.026 (0.006, 0.053) 0 (0, 0.114) 0 (0, 0.012) 0.096 (0, 0.204) 0 (0, 0.094) 0 (0, 0.064) 0 (0, 0.108)
Carboplatin count 5 5 5 5 5 5 5 5
time 16 (9, 19) 16 (9, 19) 16 (9, 19) 16 (9, 19) 16 (9, 19) 16 (9, 19) 16 (9, 19) 16 (9, 19)
n 11 (9, 20) 4 (1, 5) 5 (1, 11) 4 (3, 5) 4 (2, 4) 0 (0, 2) 3 (1, 4) 2 (1, 4)
post_p 0.86 (0.71, 0.9) 0.52 (0.51, 0.59) 0.69 (0.53, 0.82) 0.57 (0.53, 0.67) 0.56 (0.51, 0.71) 0.53 (0.51, 0.54) 0.55 (0.51, 0.62) 0.59 (0.54, 0.6)
r_prob 0.08 (0.08, 0.08) 0 (0, 0) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.06 (0.06, 0.06) 0.06 (0.06, 0.06) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33)
rate 0.07 (0.038, 0.092) 0.098 (0, 0.134) 0 (0, 0.033) 0.029 (0.011, 0.037) 0.105 (0.06, 0.2) 0.134 (0.099, 0.169) 0.033 (0.009, 0.066) 0.026 (0, 0.053)
Niraparib count 8 8 8 8 8 8 8 8
time 15 (9, 20) 15 (9, 20) 15 (9, 20) 15 (9, 20) 15 (9, 20) 15 (9, 20) 15 (9, 20) 15 (9, 20)
n 13 (9, 24) 4 (2, 5) 4 (1, 9) 3 (1, 4) 4 (3, 9) 1 (0, 2) 4 (2, 5) 2 (1, 4)
post_p 0.79 (0.75, 0.88) 0.54 (0.52, 0.58) 0.58 (0.51, 0.82) 0.53 (0.51, 0.65) 0.6 (0.51, 0.91) 0.53 (0.52, 0.58) 0.61 (0.51, 0.67) 0.56 (0.53, 0.65)
r_prob 0.08 (0.08, 0.08) 0 (0, 0) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.06 (0.06, 0.06) 0.06 (0.06, 0.06) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33)
rate 0.102 (0.047, 0.124) 0.074 (0.026, 0.122) 0 (0, 0.067) 0.033 (0, 0.077) 0.118 (0.088, 0.198) 0 (0, 0.067) 0.019 (0, 0.122) 0 (0, 0.039)
DRD+ Carboplatin count 89 89 89 89 89 89 89 89
time 23 (13, 35) 23 (13, 35) 23 (13, 35) 23 (13, 35) 23 (13, 35) 23 (13, 35) 23 (13, 35) 23 (13, 35)
n 10 (4, 19) 8 (3, 21) 5 (2, 11) 5 (2, 11) 6 (2, 12) 5 (3, 11) 4 (2, 11) 4 (2, 12)
post_p 0.8 (0.56, 0.96) 0.73 (0.52, 0.86) 0.79 (0.55, 0.96) 0.71 (0.53, 0.91) 0.76 (0.54, 0.96) 0.71 (0.55, 0.88) 0.73 (0.54, 0.97) 0.69 (0.52, 0.91)
r_prob 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33)
rate 0.026 (0, 0.046) 0.026 (0, 0.046) 0.032 (0, 0.061) 0.03 (0, 0.052) 0.03 (0, 0.076) 0.028 (0, 0.053) 0.035 (0, 0.075) 0.021 (0, 0.053)
Niraparib count 93 93 93 93 93 93 93 93
time 25 (12, 34) 25 (12, 34) 25 (12, 34) 25 (12, 34) 25 (12, 34) 25 (12, 34) 25 (12, 34) 25 (12, 34)
n 9 (3, 17) 10 (4, 17) 5 (2, 13) 5 (2, 11) 5 (2, 11) 5 (2, 12) 5 (2, 11) 5 (2, 11)
post_p 0.78 (0.55, 0.92) 0.73 (0.55, 0.88) 0.77 (0.53, 0.98) 0.71 (0.54, 0.86) 0.78 (0.54, 0.95) 0.71 (0.52, 0.95) 0.78 (0.57, 0.95) 0.69 (0.52, 0.91)
r_prob 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33)
rate 0.032 (0, 0.057) 0.025 (0, 0.043) 0.031 (0, 0.071) 0.023 (0, 0.062) 0.033 (0, 0.067) 0.025 (0, 0.06) 0.028 (0, 0.069) 0.019 (0, 0.06)
TEfus+ Taxel_therapies count 166 166 166 166 166 166 166 166
time 14 (9, 33) 14 (9, 33) 14 (9, 33) 14 (9, 33) 14 (9, 33) 14 (9, 33) 14 (9, 33) 14 (9, 33)
n 5 (2, 17) 17 (11, 40) 3 (1, 10) 2 (0, 6) 5 (3, 16) 5 (2, 14) 2 (0, 5) 2 (0, 6)
post_p 0.68 (0.52, 0.87) 0.91 (0.75, 1) 0.56 (0.51, 0.78) 0.57 (0.51, 0.78) 0.73 (0.53, 0.96) 0.74 (0.55, 0.98) 0.57 (0.51, 0.82) 0.57 (0.51, 0.75)
r_prob 0.29 (0.29, 0.29) 0.41 (0.41, 0.41) 0 (0, 0) 0 (0, 0) 0.41 (0.41, 0.41) 0.37 (0.37, 0.37) 0 (0, 0) 0 (0, 0)
rate 0.027 (0, 0.059) 0.034 (0.014, 0.056) 0 (0, 0.05) 0 (0, 0.069) 0.038 (0, 0.073) 0.025 (0, 0.066) 0 (0, 0.046) 0 (0, 0.061)
Carboplatin count 2 2 2 2 2 2 2 2
time 16 (10, 21) 16 (10, 21) 16 (10, 21) 16 (10, 21) 16 (10, 21) 16 (10, 21) 16 (10, 21) 16 (10, 21)
n 2 (0, 4) 6 (4, 8) 8 (6, 9) 8 (3, 13) 3 (2, 4) 2 (1, 2) 6 (4, 8) 6 (4, 8)
post_p 0.51 (0.51, 0.51) 0.65 (0.54, 0.76) 0.83 (0.75, 0.91) 0.76 (0.6, 0.91) 0.59 (0.55, 0.63) 0.51 (0.51, 0.52) 0.68 (0.59, 0.76) 0.75 (0.67, 0.82)
r_prob 0 (0, 0) 0 (0, 0) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0 (0, 0) 0.06 (0.06, 0.06) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33)
rate 0 (0, 0) 0.065 (0.049, 0.08) 0.004 (0.001, 0.008) 0.011 (0.002, 0.019) 0.042 (0.008, 0.075) 0.041 (0.008, 0.073) 0 (0, 0) 0.013 (0.003, 0.023)
Futility:
signature treatment var —- —+ –+- –++ -+– -+-+ -++- -+++ +— +–+ +-+- +-++ ++– ++-+ +++- ++++
all Hormone_therapies count 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4
time 4 (3, 6) 4 (3, 6) 4 (3, 6) 4 (3, 6) 4 (3, 6) 4 (3, 6) 4 (3, 6) 4 (3, 6) 4 (3, 6) 4 (3, 6) 4 (3, 6) 4 (3, 6) 4 (3, 6) 4 (3, 6) 4 (3, 6) 4 (3, 6)
n 12 (9, 16) 2 (1, 5) 12 (8, 13) 2 (0, 5) 0 (0, 3) 0 (0, 0) 0 (0, 0) 0 (0, 1) 0 (0, 3) 0 (0, 2) 0 (0, 1) 0 (0, 1) 0 (0, 0) 0 (0, 0) 0 (0, 1) 0 (0, 1)
post_p 0.35 (0.33, 0.45) 0.42 (0.39, 0.44) 0.36 (0.31, 0.4) 0.3 (0.25, 0.41) 0.43 (0.43, 0.43) NA (NA, NA) NA (NA, NA) 0.44 (0.44, 0.44) 0.42 (0.42, 0.42) 0.41 (0.41, 0.42) 0.43 (0.41, 0.44) 0.48 (0.48, 0.48) NA (NA, NA) NA (NA, NA) 0.43 (0.43, 0.43) 0.44 (0.44, 0.44)
r_prob 0.44 (0.44, 0.44) 0.35 (0.35, 0.35) 0.33 (0.33, 0.33) 0.18 (0.18, 0.18) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0.18 (0.18, 0.18) 0.18 (0.18, 0.18) 0.12 (0.12, 0.12) 0.12 (0.12, 0.12) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
rate 0.126 (0.113, 0.155) 0.19 (0.032, 0.284) 0.203 (0.157, 0.256) 0.408 (0.277, 1.764) 0.132 (0.132, 0.132) NA (NA, NA) NA (NA, NA) 0.733 (0.733, 0.733) 0.185 (0.185, 0.185) 0.931 (0.346, 1.517) 0.408 (0.36, 0.456) 0.597 (0.119, 1.074) NA (NA, NA) NA (NA, NA) 42.436 (42.436, 42.436) 0.409 (0.409, 0.409)
Niraparib count 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1
time 12 (12, 12) 12 (12, 12) 12 (12, 12) 12 (12, 12) 12 (12, 12) 12 (12, 12) 12 (12, 12) 12 (12, 12) 12 (12, 12) 12 (12, 12) 12 (12, 12) 12 (12, 12) 12 (12, 12) 12 (12, 12) 12 (12, 12) 12 (12, 12)
n 4 (4, 4) 1 (1, 1) 10 (10, 10) 2 (2, 2) 3 (3, 3) 2 (2, 2) 4 (4, 4) 6 (6, 6) 4 (4, 4) 3 (3, 3) 3 (3, 3) 6 (6, 6) 0 (0, 0) 0 (0, 0) 0 (0, 0) 3 (3, 3)
post_p 0.2 (0.2, 0.2) 0.36 (0.36, 0.36) 0.14 (0.14, 0.14) 0.49 (0.49, 0.49) 0.36 (0.36, 0.36) 0.35 (0.35, 0.35) 0.37 (0.37, 0.37) 0.45 (0.45, 0.45) 0.37 (0.37, 0.37) 0.4 (0.4, 0.4) 0.39 (0.39, 0.39) 0.48 (0.48, 0.48) NA (NA, NA) NA (NA, NA) NA (NA, NA) 0.49 (0.49, 0.49)
r_prob 0 (0, 0) 0 (0, 0) 0.08 (0.08, 0.08) 0 (0, 0) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0 (0, 0) 0 (0, 0) 0.06 (0.06, 0.06) 0.06 (0.06, 0.06) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33)
rate 0.289 (0.289, 0.289) 0.24 (0.24, 0.24) 0.246 (0.246, 0.246) 0.1 (0.1, 0.1) 0.087 (0.087, 0.087) 0.361 (0.361, 0.361) 0.13 (0.13, 0.13) 0.072 (0.072, 0.072) 0.209 (0.209, 0.209) 0.162 (0.162, 0.162) 0.214 (0.214, 0.214) 0.087 (0.087, 0.087) NA (NA, NA) NA (NA, NA) NA (NA, NA) 0.06 (0.06, 0.06)
TP53- & AR- Hormone_therapies count 1 1 1 1
time 13 (13, 13) 13 (13, 13) 13 (13, 13) 13 (13, 13)
n 41 (41, 41) 5 (5, 5) 0 (0, 0) 0 (0, 0)
post_p 0.42 (0.42, 0.42) 0.2 (0.2, 0.2) NA (NA, NA) NA (NA, NA)
r_prob 0.44 (0.44, 0.44) 0.35 (0.35, 0.35) 0 (0, 0) 0 (0, 0)
rate 0.079 (0.079, 0.079) 0.128 (0.128, 0.128) NA (NA, NA) NA (NA, NA)
Taxel_therapies count 84 84 84 84
time 22 (13, 32) 22 (13, 32) 22 (13, 32) 22 (13, 32)
n 13 (8, 30) 6 (2, 12) 3 (2, 7) 5 (1, 9)
post_p 0.1 (0.02, 0.31) 0.43 (0.29, 0.49) 0.26 (0.14, 0.44) 0.42 (0.25, 0.49)
r_prob 0.11 (0.11, 0.11) 0.29 (0.29, 0.29) 0 (0, 0) 0 (0, 0)
rate 0.164 (0.113, 0.268) 0.075 (0.051, 0.162) 0.205 (0.094, 0.653) 0.066 (0.038, 0.152)
Carboplatin count 71 71 71 71
time 17 (11, 28) 17 (11, 28) 17 (11, 28) 17 (11, 28)
n 13 (7, 27) 4 (2, 9) 6 (2, 9) 6 (3, 11)
post_p 0.11 (0.02, 0.32) 0.31 (0.09, 0.43) 0.45 (0.27, 0.49) 0.44 (0.29, 0.49)
r_prob 0 (0, 0) 0 (0, 0) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33)
rate 0.166 (0.118, 0.328) 0.2 (0.104, 0.483) 0.072 (0.046, 0.257) 0.051 (0.029, 0.085)
Niraparib count 79 79 79 79
time 17 (14, 25) 17 (14, 25) 17 (14, 25) 17 (14, 25)
n 15 (9, 37) 4 (2, 7) 5 (2, 11) 6 (3, 11)
post_p 0.13 (0.02, 0.33) 0.32 (0.12, 0.44) 0.45 (0.34, 0.49) 0.44 (0.26, 0.49)
r_prob 0 (0, 0) 0 (0, 0) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33)
rate 0.158 (0.115, 0.244) 0.173 (0.086, 0.598) 0.076 (0.046, 0.185) 0.06 (0.032, 0.126)
TP53+ Hormone_therapies count 256 256 256 256 256 256 256 256
time 22 (13, 32) 22 (13, 32) 22 (13, 32) 22 (13, 32) 22 (13, 32) 22 (13, 32) 22 (13, 32) 22 (13, 32)
n 14 (7, 36) 6 (4, 14) 2 (1, 5) 2 (1, 5) 4 (1, 10) 3 (2, 7) 3 (1, 5) 2 (1, 5)
post_p 0.3 (0.08, 0.47) 0.23 (0.08, 0.42) 0.38 (0.23, 0.48) 0.37 (0.2, 0.46) 0.39 (0.23, 0.47) 0.36 (0.16, 0.47) 0.38 (0.21, 0.47) 0.36 (0.2, 0.46)
r_prob 0.33 (0.33, 0.33) 0.18 (0.18, 0.18) 0 (0, 0) 0 (0, 0) 0.12 (0.12, 0.12) 0.12 (0.12, 0.12) 0 (0, 0) 0 (0, 0)
rate 0.184 (0.141, 0.293) 0.159 (0.106, 0.305) 0.2 (0.099, 0.713) 0.191 (0.084, 0.717) 0.22 (0.136, 0.548) 0.193 (0.108, 0.47) 0.215 (0.097, 0.645) 0.19 (0.082, 0.616)
Taxel_therapies count 1 1 1 1 1 1 1 1
time 10 (10, 10) 10 (10, 10) 10 (10, 10) 10 (10, 10) 10 (10, 10) 10 (10, 10) 10 (10, 10) 10 (10, 10)
n 11 (11, 11) 15 (15, 15) 0 (0, 0) 1 (1, 1) 4 (4, 4) 3 (3, 3) 0 (0, 0) 0 (0, 0)
post_p 0.41 (0.41, 0.41) 0.32 (0.32, 0.32) NA (NA, NA) 0.49 (0.49, 0.49) 0.44 (0.44, 0.44) 0.5 (0.5, 0.5) NA (NA, NA) NA (NA, NA)
r_prob 0.17 (0.17, 0.17) 0.41 (0.41, 0.41) 0 (0, 0) 0 (0, 0) 0.37 (0.37, 0.37) 0.37 (0.37, 0.37) 0 (0, 0) 0 (0, 0)
rate 0.148 (0.148, 0.148) 0.08 (0.08, 0.08) NA (NA, NA) 0 (0, 0) 0.17 (0.17, 0.17) 0.123 (0.123, 0.123) NA (NA, NA) NA (NA, NA)
Niraparib count 3 3 3 3 3 3 3 3
time 14 (12, 17) 14 (12, 17) 14 (12, 17) 14 (12, 17) 14 (12, 17) 14 (12, 17) 14 (12, 17) 14 (12, 17)
n 9 (8, 10) 3 (2, 4) 1 (1, 3) 1 (0, 5) 4 (3, 7) 6 (3, 8) 0 (0, 2) 3 (3, 3)
post_p 0.14 (0.14, 0.38) 0.28 (0.18, 0.45) 0.4 (0.37, 0.44) 0.47 (0.45, 0.49) 0.39 (0.39, 0.42) 0.33 (0.29, 0.45) 0.42 (0.42, 0.42) 0.44 (0.34, 0.48)
r_prob 0.08 (0.08, 0.08) 0 (0, 0) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.06 (0.06, 0.06) 0.06 (0.06, 0.06) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33)
rate 0.246 (0.203, 0.306) 0.198 (0.119, 0.311) 0.376 (0.18, 0.466) 0.036 (0.007, 0.065) 0.223 (0.216, 0.282) 0.087 (0.082, 1.361) 0.077 (0.077, 0.077) 0.06 (0.034, 0.14)
DRD+ Hormone_therapies count 51 51 51 51 51 51 51 51
time 28 (21, 34) 28 (21, 34) 28 (21, 34) 28 (21, 34) 28 (21, 34) 28 (21, 34) 28 (21, 34) 28 (21, 34)
n 4 (0, 9) 4 (0, 11) 3 (1, 5) 3 (1, 5) 3 (1, 7) 3 (2, 7) 3 (1, 7) 3 (1, 6)
post_p 0.41 (0.26, 0.48) 0.39 (0.26, 0.48) 0.31 (0.19, 0.43) 0.32 (0.16, 0.46) 0.34 (0.2, 0.46) 0.29 (0.17, 0.46) 0.38 (0.24, 0.48) 0.31 (0.14, 0.44)
r_prob 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
rate 0.088 (0.051, 0.163) 0.066 (0.046, 0.157) 0.206 (0.122, 0.619) 0.19 (0.079, 0.854) 0.21 (0.107, 0.6) 0.16 (0.084, 0.448) 0.18 (0.091, 0.767) 0.17 (0.087, 0.579)
Taxel_therapies count 8 8 8 8 8 8 8 8
time 26 (20, 33) 26 (20, 33) 26 (20, 33) 26 (20, 33) 26 (20, 33) 26 (20, 33) 26 (20, 33) 26 (20, 33)
n 4 (3, 12) 6 (4, 8) 4 (2, 6) 2 (1, 6) 2 (1, 5) 3 (1, 7) 2 (2, 5) 4 (0, 8)
post_p 0.27 (0.12, 0.39) 0.36 (0.25, 0.41) 0.3 (0.18, 0.4) 0.46 (0.27, 0.48) 0.33 (0.29, 0.43) 0.37 (0.36, 0.45) 0.37 (0.27, 0.47) 0.41 (0.38, 0.48)
r_prob 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
rate 0.154 (0.106, 0.185) 0.069 (0.052, 0.105) 0.218 (0.142, 1.413) 0.124 (0.057, 0.261) 0.233 (0.144, 0.887) 0.097 (0.057, 0.185) 0.245 (0.109, 3.523) 0.078 (0.061, 0.15)
Carboplatin count 1 1 1 1 1 1 1 1
time 14 (14, 14) 14 (14, 14) 14 (14, 14) 14 (14, 14) 14 (14, 14) 14 (14, 14) 14 (14, 14) 14 (14, 14)
n 8 (8, 8) 4 (4, 4) 5 (5, 5) 2 (2, 2) 4 (4, 4) 0 (0, 0) 1 (1, 1) 2 (2, 2)
post_p 0.38 (0.38, 0.38) 0.38 (0.38, 0.38) 0.32 (0.32, 0.32) 0.38 (0.38, 0.38) 0.44 (0.44, 0.44) NA (NA, NA) 0.48 (0.48, 0.48) 0.46 (0.46, 0.46)
r_prob 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33)
rate 0.074 (0.074, 0.074) 0.143 (0.143, 0.143) 0.104 (0.104, 0.104) 0.152 (0.152, 0.152) 0.119 (0.119, 0.119) NA (NA, NA) 0.107 (0.107, 0.107) 0.068 (0.068, 0.068)
TEfus+ Hormone_therapies count 112 112 112 112 112 112 112 112
time 22 (15, 32) 22 (15, 32) 22 (15, 32) 22 (15, 32) 22 (15, 32) 22 (15, 32) 22 (15, 32) 22 (15, 32)
n 5 (2, 13) 7 (4, 15) 4 (0, 9) 2 (1, 5) 3 (2, 8) 3 (2, 6) 3 (1, 5) 3 (1, 5)
post_p 0.43 (0.27, 0.49) 0.21 (0.07, 0.41) 0.42 (0.28, 0.48) 0.37 (0.23, 0.47) 0.33 (0.16, 0.43) 0.33 (0.14, 0.47) 0.37 (0.18, 0.47) 0.36 (0.21, 0.46)
r_prob 0.35 (0.35, 0.35) 0.18 (0.18, 0.18) 0 (0, 0) 0 (0, 0) 0.18 (0.18, 0.18) 0.12 (0.12, 0.12) 0 (0, 0) 0 (0, 0)
rate 0.073 (0.045, 0.173) 0.168 (0.113, 0.377) 0.068 (0.042, 0.157) 0.148 (0.074, 0.589) 0.215 (0.113, 0.63) 0.177 (0.111, 0.443) 0.177 (0.067, 0.549) 0.177 (0.083, 0.672)
Carboplatin count 8 8 8 8 8 8 8 8
time 18 (12, 29) 18 (12, 29) 18 (12, 29) 18 (12, 29) 18 (12, 29) 18 (12, 29) 18 (12, 29) 18 (12, 29)
n 6 (3, 8) 8 (5, 9) 6 (5, 8) 4 (1, 6) 2 (1, 5) 3 (2, 5) 2 (1, 6) 4 (2, 6)
post_p 0.25 (0.08, 0.4) 0.29 (0.13, 0.39) 0.43 (0.32, 0.48) 0.45 (0.35, 0.48) 0.34 (0.27, 0.43) 0.37 (0.21, 0.49) 0.39 (0.29, 0.47) 0.43 (0.34, 0.47)
r_prob 0 (0, 0) 0 (0, 0) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0 (0, 0) 0.06 (0.06, 0.06) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33)
rate 0.276 (0.108, 0.339) 0.146 (0.13, 0.325) 0.051 (0.043, 0.076) 0.062 (0.048, 0.132) 0.309 (0.157, 0.441) 0.191 (0.123, 0.349) 0.071 (0.027, 0.233) 0.069 (0.051, 0.3)
Niraparib count 8 8 8 8 8 8 8 8
time 14 (11, 24) 14 (11, 24) 14 (11, 24) 14 (11, 24) 14 (11, 24) 14 (11, 24) 14 (11, 24) 14 (11, 24)
n 3 (2, 4) 7 (4, 12) 7 (4, 11) 4 (2, 6) 2 (1, 5) 4 (3, 5) 2 (1, 6) 2 (2, 4)
post_p 0.38 (0.28, 0.47) 0.21 (0.13, 0.42) 0.43 (0.4, 0.48) 0.48 (0.41, 0.49) 0.42 (0.3, 0.47) 0.43 (0.31, 0.46) 0.44 (0.33, 0.48) 0.43 (0.34, 0.48)
r_prob 0 (0, 0) 0 (0, 0) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0 (0, 0) 0.06 (0.06, 0.06) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33)
rate 0.163 (0.103, 0.222) 0.172 (0.118, 0.371) 0.042 (0.036, 0.077) 0.072 (0.019, 0.086) 0.223 (0.131, 1.554) 0.125 (0.091, 0.239) 0.077 (0.028, 0.271) 0.122 (0.055, 0.319)