Simulation scenario 7, CR phase

Setting description

Several treatments more effective in distinctive signatures: (Hormone therapies, TP53- & AR-); (Taxel therapies, TEfus+); (Carboplatin and Niraparib, DRD+)

Simulations setting

Survival curves (by signature)

PFS distributions (by signature)

Treatment effects (by signature)

signature	var	Other	Hormone_therapies	Taxel_therapies	Carboplatin	Niraparib
all	param	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.114, shape = 1.05	scale = 0.124, shape = 1.05	scale = 0.124, shape = 1.05
	summary	mean = 8.8, median = 6.3	mean = 8.7, median = 6.3	mean = 8.6, median = 6.2	mean = 7.9, median = 5.7	mean = 7.9, median = 5.7
	effect	af = 1, hr = 1	af = 0.99, hr = 1.01	af = 0.98, hr = 1.02	af = 0.9, hr = 1.12	af = 0.9, hr = 1.12
TP53- & AR-	param	scale = 0.112, shape = 1.05	scale = 0.043, shape = 1.05	scale = 0.128, shape = 1.05	scale = 0.127, shape = 1.05	scale = 0.127, shape = 1.05
	summary	mean = 8.8, median = 6.3	mean = 22.6, median = 16.3	mean = 7.7, median = 5.5	mean = 7.7, median = 5.5	mean = 7.7, median = 5.5
	effect	af = 1, hr = 1	af = 2.58, hr = 0.37	af = 0.87, hr = 1.15	af = 0.88, hr = 1.15	af = 0.88, hr = 1.15
TP53+	param	scale = 0.112, shape = 1.05	scale = 0.157, shape = 1.05	scale = 0.105, shape = 1.05	scale = 0.125, shape = 1.05	scale = 0.125, shape = 1.05
	summary	mean = 8.8, median = 6.3	mean = 6.3, median = 4.5	mean = 9.3, median = 6.7	mean = 7.8, median = 5.6	mean = 7.8, median = 5.6
	effect	af = 1, hr = 1	af = 0.71, hr = 1.43	af = 1.06, hr = 0.94	af = 0.89, hr = 1.13	af = 0.89, hr = 1.13
DRD+	param	scale = 0.112, shape = 1.05	scale = 0.117, shape = 1.05	scale = 0.099, shape = 1.05	scale = 0.037, shape = 1.05	scale = 0.037, shape = 1.05
	summary	mean = 8.8, median = 6.3	mean = 8.4, median = 6	mean = 9.9, median = 7.1	mean = 26.6, median = 19.1	mean = 26.6, median = 19.1
	effect	af = 1, hr = 1	af = 0.95, hr = 1.05	af = 1.13, hr = 0.88	af = 3.03, hr = 0.31	af = 3.03, hr = 0.31
TEfus+	param	scale = 0.112, shape = 1.05	scale = 0.127, shape = 1.05	scale = 0.039, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05
	summary	mean = 8.8, median = 6.3	mean = 7.7, median = 5.6	mean = 25, median = 18	mean = 8.7, median = 6.3	mean = 8.7, median = 6.3
	effect	af = 1, hr = 1	af = 0.88, hr = 1.14	af = 2.85, hr = 0.33	af = 0.99, hr = 1.01	af = 0.99, hr = 1.01

Survival curves (by subgroup)

PFS distributions (by subgroup)

Treatment effects (by subgroup)

subtype	var	Other	Hormone_therapies	Taxel_therapies	Carboplatin	Niraparib
—-	param	scale = 0.112, shape = 1.05	scale = 0.043, shape = 1.05	scale = 0.157, shape = 1.05	scale = 0.157, shape = 1.05	scale = 0.157, shape = 1.05
	summary	mean = 8.8, median = 6.3	mean = 22.6, median = 16.3	mean = 6.3, median = 4.5	mean = 6.3, median = 4.5	mean = 6.3, median = 4.5
	effect	af = 1, hr = 1	af = 2.58, hr = 0.37	af = 0.71, hr = 1.43	af = 0.71, hr = 1.43	af = 0.71, hr = 1.43
—+	param	scale = 0.112, shape = 1.05	scale = 0.043, shape = 1.05	scale = 0.039, shape = 1.05	scale = 0.157, shape = 1.05	scale = 0.157, shape = 1.05
	summary	mean = 8.8, median = 6.3	mean = 22.6, median = 16.3	mean = 25, median = 18	mean = 6.3, median = 4.5	mean = 6.3, median = 4.5
	effect	af = 1, hr = 1	af = 2.58, hr = 0.37	af = 2.85, hr = 0.33	af = 0.71, hr = 1.43	af = 0.71, hr = 1.43
–+-	param	scale = 0.112, shape = 1.05	scale = 0.157, shape = 1.05	scale = 0.157, shape = 1.05	scale = 0.157, shape = 1.05	scale = 0.157, shape = 1.05
	summary	mean = 8.8, median = 6.3	mean = 6.3, median = 4.5	mean = 6.3, median = 4.5	mean = 6.3, median = 4.5	mean = 6.3, median = 4.5
	effect	af = 1, hr = 1	af = 0.71, hr = 1.43	af = 0.71, hr = 1.43	af = 0.71, hr = 1.43	af = 0.71, hr = 1.43
–++	param	scale = 0.112, shape = 1.05	scale = 0.157, shape = 1.05	scale = 0.039, shape = 1.05	scale = 0.157, shape = 1.05	scale = 0.157, shape = 1.05
	summary	mean = 8.8, median = 6.3	mean = 6.3, median = 4.5	mean = 25, median = 18	mean = 6.3, median = 4.5	mean = 6.3, median = 4.5
	effect	af = 1, hr = 1	af = 0.71, hr = 1.43	af = 2.85, hr = 0.33	af = 0.71, hr = 1.43	af = 0.71, hr = 1.43
-+–	param	scale = 0.112, shape = 1.05	scale = 0.043, shape = 1.05	scale = 0.157, shape = 1.05	scale = 0.037, shape = 1.05	scale = 0.037, shape = 1.05
	summary	mean = 8.8, median = 6.3	mean = 22.6, median = 16.3	mean = 6.3, median = 4.5	mean = 26.6, median = 19.1	mean = 26.6, median = 19.1
	effect	af = 1, hr = 1	af = 2.58, hr = 0.37	af = 0.71, hr = 1.43	af = 3.03, hr = 0.31	af = 3.03, hr = 0.31
-+-+	param	scale = 0.112, shape = 1.05	scale = 0.043, shape = 1.05	scale = 0.039, shape = 1.05	scale = 0.037, shape = 1.05	scale = 0.037, shape = 1.05
	summary	mean = 8.8, median = 6.3	mean = 22.6, median = 16.3	mean = 25, median = 18	mean = 26.6, median = 19.1	mean = 26.6, median = 19.1
	effect	af = 1, hr = 1	af = 2.58, hr = 0.37	af = 2.85, hr = 0.33	af = 3.03, hr = 0.31	af = 3.03, hr = 0.31
-++-	param	scale = 0.112, shape = 1.05	scale = 0.157, shape = 1.05	scale = 0.157, shape = 1.05	scale = 0.037, shape = 1.05	scale = 0.037, shape = 1.05
	summary	mean = 8.8, median = 6.3	mean = 6.3, median = 4.5	mean = 6.3, median = 4.5	mean = 26.6, median = 19.1	mean = 26.6, median = 19.1
	effect	af = 1, hr = 1	af = 0.71, hr = 1.43	af = 0.71, hr = 1.43	af = 3.03, hr = 0.31	af = 3.03, hr = 0.31
-+++	param	scale = 0.112, shape = 1.05	scale = 0.157, shape = 1.05	scale = 0.039, shape = 1.05	scale = 0.037, shape = 1.05	scale = 0.037, shape = 1.05
	summary	mean = 8.8, median = 6.3	mean = 6.3, median = 4.5	mean = 25, median = 18	mean = 26.6, median = 19.1	mean = 26.6, median = 19.1
	effect	af = 1, hr = 1	af = 0.71, hr = 1.43	af = 2.85, hr = 0.33	af = 3.03, hr = 0.31	af = 3.03, hr = 0.31
+—	param	scale = 0.112, shape = 1.05	scale = 0.157, shape = 1.05	scale = 0.157, shape = 1.05	scale = 0.157, shape = 1.05	scale = 0.157, shape = 1.05
	summary	mean = 8.8, median = 6.3	mean = 6.3, median = 4.5	mean = 6.3, median = 4.5	mean = 6.3, median = 4.5	mean = 6.3, median = 4.5
	effect	af = 1, hr = 1	af = 0.71, hr = 1.43	af = 0.71, hr = 1.43	af = 0.71, hr = 1.43	af = 0.71, hr = 1.43
+–+	param	scale = 0.112, shape = 1.05	scale = 0.157, shape = 1.05	scale = 0.039, shape = 1.05	scale = 0.157, shape = 1.05	scale = 0.157, shape = 1.05
	summary	mean = 8.8, median = 6.3	mean = 6.3, median = 4.5	mean = 25, median = 18	mean = 6.3, median = 4.5	mean = 6.3, median = 4.5
	effect	af = 1, hr = 1	af = 0.71, hr = 1.43	af = 2.85, hr = 0.33	af = 0.71, hr = 1.43	af = 0.71, hr = 1.43
+-+-	param	scale = 0.112, shape = 1.05	scale = 0.157, shape = 1.05	scale = 0.157, shape = 1.05	scale = 0.157, shape = 1.05	scale = 0.157, shape = 1.05
	summary	mean = 8.8, median = 6.3	mean = 6.3, median = 4.5	mean = 6.3, median = 4.5	mean = 6.3, median = 4.5	mean = 6.3, median = 4.5
	effect	af = 1, hr = 1	af = 0.71, hr = 1.43	af = 0.71, hr = 1.43	af = 0.71, hr = 1.43	af = 0.71, hr = 1.43
+-++	param	scale = 0.112, shape = 1.05	scale = 0.157, shape = 1.05	scale = 0.039, shape = 1.05	scale = 0.157, shape = 1.05	scale = 0.157, shape = 1.05
	summary	mean = 8.8, median = 6.3	mean = 6.3, median = 4.5	mean = 25, median = 18	mean = 6.3, median = 4.5	mean = 6.3, median = 4.5
	effect	af = 1, hr = 1	af = 0.71, hr = 1.43	af = 2.85, hr = 0.33	af = 0.71, hr = 1.43	af = 0.71, hr = 1.43
++–	param	scale = 0.112, shape = 1.05	scale = 0.157, shape = 1.05	scale = 0.157, shape = 1.05	scale = 0.037, shape = 1.05	scale = 0.037, shape = 1.05
	summary	mean = 8.8, median = 6.3	mean = 6.3, median = 4.5	mean = 6.3, median = 4.5	mean = 26.6, median = 19.1	mean = 26.6, median = 19.1
	effect	af = 1, hr = 1	af = 0.71, hr = 1.43	af = 0.71, hr = 1.43	af = 3.03, hr = 0.31	af = 3.03, hr = 0.31
++-+	param	scale = 0.112, shape = 1.05	scale = 0.157, shape = 1.05	scale = 0.039, shape = 1.05	scale = 0.037, shape = 1.05	scale = 0.037, shape = 1.05
	summary	mean = 8.8, median = 6.3	mean = 6.3, median = 4.5	mean = 25, median = 18	mean = 26.6, median = 19.1	mean = 26.6, median = 19.1
	effect	af = 1, hr = 1	af = 0.71, hr = 1.43	af = 2.85, hr = 0.33	af = 3.03, hr = 0.31	af = 3.03, hr = 0.31
+++-	param	scale = 0.112, shape = 1.05	scale = 0.157, shape = 1.05	scale = 0.157, shape = 1.05	scale = 0.037, shape = 1.05	scale = 0.037, shape = 1.05
	summary	mean = 8.8, median = 6.3	mean = 6.3, median = 4.5	mean = 6.3, median = 4.5	mean = 26.6, median = 19.1	mean = 26.6, median = 19.1
	effect	af = 1, hr = 1	af = 0.71, hr = 1.43	af = 0.71, hr = 1.43	af = 3.03, hr = 0.31	af = 3.03, hr = 0.31
++++	param	scale = 0.112, shape = 1.05	scale = 0.157, shape = 1.05	scale = 0.039, shape = 1.05	scale = 0.037, shape = 1.05	scale = 0.037, shape = 1.05
	summary	mean = 8.8, median = 6.3	mean = 6.3, median = 4.5	mean = 25, median = 18	mean = 26.6, median = 19.1	mean = 26.6, median = 19.1
	effect	af = 1, hr = 1	af = 0.71, hr = 1.43	af = 2.85, hr = 0.33	af = 3.03, hr = 0.31	af = 3.03, hr = 0.31

Errors and power

graduation (counts and proportions):

Hormone_therapies Taxel_therapies Carboplatin Niraparib all 11 1 4 5 TP53- & AR- 291 1 1 1 TP53+ 2 27 5 8 DRD+ 0 0 89 93 TEfus+ 0 166 2 0

Hormone_therapies Taxel_therapies Carboplatin Niraparib all 0.022 0.002 0.008 0.010 TP53- & AR- 0.582 0.002 0.002 0.002 TP53+ 0.004 0.054 0.010 0.016 DRD+ 0.000 0.000 0.178 0.186 TEfus+ 0.000 0.332 0.004 0.000

futility (counts and proportions):

Hormone_therapies Taxel_therapies Carboplatin Niraparib all 4 0 0 1 TP53- & AR- 1 84 71 79 TP53+ 256 1 0 3 DRD+ 51 8 1 0 TEfus+ 112 0 8 8

Hormone_therapies Taxel_therapies Carboplatin Niraparib all 0.008 0.000 0.000 0.002 TP53- & AR- 0.002 0.168 0.142 0.158 TP53+ 0.512 0.002 0.000 0.006 DRD+ 0.102 0.016 0.002 0.000 TEfus+ 0.224 0.000 0.016 0.016

max sample size (counts and proportions):

Hormone_therapies Taxel_therapies Carboplatin Niraparib all 0 0 0 0 TP53- & AR- 143 11 33 40 TP53+ 0 42 14 8 DRD+ 0 0 0 0 TEfus+ 0 28 3 0

Hormone_therapies Taxel_therapies Carboplatin Niraparib all 0.000 0.000 0.000 0.000 TP53- & AR- 0.286 0.022 0.066 0.080 TP53+ 0.000 0.084 0.028 0.016 DRD+ 0.000 0.000 0.000 0.000 TEfus+ 0.000 0.056 0.006 0.000

Errors & power

The overall error was 0.082.
The corresponding errors separate for the different treatments were:

Hormone_therapies   Taxel_therapies       Carboplatin         Niraparib 
            0.020             0.034             0.014             0.016 

The overall power was 0.808.
The corresponding power separate for the different treatments were:

Hormone_therapies   Taxel_therapies       Carboplatin         Niraparib 
            0.582             0.332             0.178             0.186 

Median results at the end of the trial

By signature:

signature	var	Control	Hormone_therapies	Taxel_therapies	Carboplatin	Niraparib
all	graduation	0	11	1	4	5
	futility	0	4	0	0	1
	max_n	0	0	0	0	0
	n	446 (420, 478)	160 (85, 246)	195 (111, 262)	176 (130, 258)	173 (121, 255)
	n_unique	408 (385, 439)	148 (77, 233)	178 (98, 242)	159 (117, 242)	158 (112, 237)
	time_trial	36 (36, 36)	36 (36, 36)	36 (36, 36)	36 (36, 36)	36 (36, 36)
	time_stop	NA (NA, NA)	5 (3, 7)	5 (5, 5)	6 (6, 7)	8 (5, 11)
	post_p	NA (NA, NA)	0.95 (0.17, 1)	0.99 (0.49, 1)	0.92 (0.25, 1)	0.9 (0.24, 1)
	rate	0.094 (0.087, 0.101)	0.077 (0.061, 0.102)	0.072 (0.06, 0.091)	0.079 (0.065, 0.098)	0.08 (0.066, 0.098)
TP53- & AR-	graduation	0	291	1	1	1
	futility	0	1	84	71	79
	max_n	0	143	11	33	40
	n	193 (173, 213)	66 (26, 153)	44 (25, 117)	51 (28, 138)	51 (28, 141)
	n_unique	178 (160, 200)	64 (25, 146)	40 (21, 111)	46 (26, 132)	46 (25, 134)
	time_trial	36 (36, 36)	20 (8, 36)	36 (23, 36)	36 (21, 36)	36 (19, 36)
	time_stop	NA (NA, NA)	10 (7, 23)	22 (13, 32)	16 (11, 28)	17 (14, 25)
	post_p	NA (NA, NA)	1 (0.97, 1)	0.32 (0.01, 0.9)	0.5 (0, 0.96)	0.41 (0, 0.93)
	rate	0.075 (0.066, 0.085)	0.042 (0.034, 0.051)	0.083 (0.055, 0.12)	0.075 (0.052, 0.113)	0.078 (0.052, 0.116)
TP53+	graduation	0	2	27	5	8
	futility	0	256	1	0	3
	max_n	0	0	42	14	8
	n	193 (173, 216)	56 (28, 93)	110 (52, 145)	84 (57, 123)	82 (53, 120)
	n_unique	176 (156, 197)	51 (26, 86)	100 (48, 135)	77 (51, 115)	75 (48, 112)
	time_trial	36 (36, 36)	34 (15, 36)	36 (36, 36)	36 (36, 36)	36 (36, 36)
	time_stop	NA (NA, NA)	22 (13, 32)	10 (8, 15)	16 (9, 19)	14 (9, 18)
	post_p	NA (NA, NA)	0.02 (0, 0.14)	1 (0.9, 1)	0.95 (0.54, 1)	0.95 (0.54, 1)
	rate	0.113 (0.102, 0.126)	0.161 (0.137, 0.198)	0.067 (0.051, 0.089)	0.085 (0.065, 0.109)	0.085 (0.063, 0.108)
DRD+	graduation	0	0	0	89	93
	futility	0	51	8	1	0
	max_n	0	0	0	0	0
	n	111 (96, 128)	27 (17, 44)	38 (21, 57)	79 (50, 101)	76 (46, 99)
	n_unique	100 (86, 116)	24 (15, 40)	34 (19, 52)	72 (45, 93)	70 (42, 91)
	time_trial	36 (36, 36)	36 (35, 36)	36 (36, 36)	36 (26, 36)	36 (27, 36)
	time_stop	NA (NA, NA)	28 (21, 34)	26 (20, 33)	23 (13, 35)	25 (12, 34)
	post_p	NA (NA, NA)	0.23 (0.02, 0.79)	0.76 (0.22, 0.98)	1 (1, 1)	1 (1, 1)
	rate	0.091 (0.078, 0.107)	0.103 (0.069, 0.159)	0.07 (0.05, 0.099)	0.036 (0.029, 0.044)	0.036 (0.029, 0.045)
TEfus+	graduation	0	0	166	2	0
	futility	0	112	0	8	8
	max_n	0	0	28	3	0
	n	161 (143, 179)	39 (24, 61)	114 (31, 144)	63 (43, 102)	62 (41, 95)
	n_unique	147 (130, 164)	35 (22, 56)	104 (28, 133)	58 (39, 95)	57 (38, 87)
	time_trial	36 (36, 36)	36 (21, 36)	36 (11, 36)	36 (36, 36)	36 (36, 36)
	time_stop	NA (NA, NA)	22 (15, 32)	14 (9, 33)	18 (12, 27)	14 (11, 24)
	post_p	NA (NA, NA)	0.08 (0, 0.55)	1 (0.99, 1)	0.69 (0.12, 0.96)	0.7 (0.15, 0.97)
	rate	0.076 (0.066, 0.087)	0.101 (0.075, 0.138)	0.038 (0.031, 0.046)	0.068 (0.052, 0.088)	0.067 (0.05, 0.09)

By subgroup combinations:

subtype	var	Control	Hormone_therapies	Taxel_therapies	Carboplatin	Niraparib
—-	graduation	0	306	86	76	86
	futility	0	0	0	0	0
	max_n	0	143	11	33	40
	n	129 (114, 144)	53 (21, 124)	15 (8, 85)	15 (7, 95)	16 (7, 99)
	n_unique	120 (106, 136)	50 (20, 120)	13 (7, 82)	13 (6, 90)	14 (6, 94)
	post_p	NA (NA, NA)	1 (0.99, 1)	0.04 (0, 0.15)	0.04 (0, 0.13)	0.03 (0, 0.15)
	rate	0.083 (0.072, 0.097)	0.042 (0.033, 0.052)	0.165 (0.128, 0.268)	0.17 (0.132, 0.299)	0.169 (0.132, 0.281)
—+	graduation	0	344	237	83	92
	futility	0	0	0	0	0
	max_n	0	139	37	34	40
	n	22 (15, 29)	5 (2, 18)	14 (3, 25)	6 (3, 15)	5 (2, 14)
	n_unique	20 (14, 27)	5 (2, 17)	13 (3, 23)	5 (2, 14)	5 (2, 13)
	post_p	NA (NA, NA)	0.68 (0.33, 0.92)	0.81 (0.39, 0.97)	0.14 (0.03, 0.3)	0.14 (0.03, 0.33)
	rate	0.053 (0.033, 0.081)	0.044 (0.021, 0.097)	0.039 (0.021, 0.081)	0.176 (0.108, 0.36)	0.176 (0.104, 0.414)
–+-	graduation	0	273	29	9	15
	futility	0	0	0	0	0
	max_n	0	0	42	14	8
	n	65 (52, 80)	20 (8, 53)	24 (7, 58)	23 (6, 56)	22 (6, 55)
	n_unique	60 (47, 74)	19 (8, 49)	22 (7, 55)	21 (5, 53)	20 (6, 52)
	post_p	NA (NA, NA)	0.32 (0.09, 0.74)	0.34 (0.08, 0.79)	0.29 (0.08, 0.75)	0.31 (0.08, 0.73)
	rate	0.145 (0.121, 0.172)	0.169 (0.132, 0.263)	0.165 (0.13, 0.285)	0.172 (0.129, 0.315)	0.173 (0.133, 0.301)
–++	graduation	0	320	183	19	23
	futility	0	0	0	0	0
	max_n	0	0	65	16	8
	n	48 (38, 58)	7 (4, 15)	41 (13, 54)	8 (4, 33)	7 (4, 25)
	n_unique	44 (35, 54)	6 (3, 14)	38 (12, 50)	7 (3, 31)	6 (3, 23)
	post_p	NA (NA, NA)	0.15 (0.05, 0.36)	1 (0.96, 1)	0.14 (0.03, 0.35)	0.14 (0.03, 0.32)
	rate	0.088 (0.068, 0.111)	0.172 (0.116, 0.304)	0.038 (0.027, 0.053)	0.169 (0.121, 0.358)	0.182 (0.122, 0.333)
-+–	graduation	0	325	91	160	169
	futility	0	0	0	0	0
	max_n	0	139	11	31	38
	n	21 (14, 27)	3 (0, 12)	4 (2, 9)	14 (4, 24)	13 (4, 23)
	n_unique	19 (12, 25)	3 (0, 12)	4 (2, 8)	13 (4, 23)	12 (3, 21)
	post_p	NA (NA, NA)	0.68 (0.36, 0.92)	0.18 (0.07, 0.36)	0.88 (0.5, 0.99)	0.84 (0.47, 0.98)
	rate	0.084 (0.058, 0.124)	0.044 (0.016, 0.104)	0.185 (0.106, 0.451)	0.036 (0.02, 0.065)	0.038 (0.021, 0.074)
-+-+	graduation	0	352	242	166	175
	futility	0	0	0	0	0
	max_n	0	135	37	32	38
	n	20 (15, 28)	3 (0, 11)	7 (2, 18)	12 (4, 22)	12 (4, 22)
	n_unique	19 (13, 25)	3 (0, 11)	6 (1, 16)	11 (4, 20)	11 (4, 20)
	post_p	NA (NA, NA)	0.5 (0.26, 0.77)	0.55 (0.24, 0.84)	0.62 (0.31, 0.88)	0.62 (0.27, 0.9)
	rate	0.053 (0.032, 0.081)	0.045 (0.017, 0.131)	0.042 (0.018, 0.095)	0.038 (0.022, 0.067)	0.037 (0.02, 0.074)
-++-	graduation	0	297	37	95	103
	futility	0	0	0	0	0
	max_n	0	0	42	13	8
	n	11 (7, 16)	3 (1, 6)	3 (1, 6)	8 (3, 15)	9 (3, 15)
	n_unique	10 (6, 15)	3 (0, 5)	3 (1, 6)	8 (2, 14)	8 (2, 14)
	post_p	NA (NA, NA)	0.34 (0.18, 0.55)	0.32 (0.18, 0.53)	0.9 (0.65, 0.99)	0.9 (0.61, 0.99)
	rate	0.149 (0.098, 0.23)	0.193 (0.092, 0.611)	0.188 (0.093, 0.53)	0.036 (0.016, 0.075)	0.037 (0.016, 0.083)
-+++	graduation	0	330	190	104	111
	futility	0	0	0	0	0
	max_n	0	0	65	15	8
	n	12 (7, 17)	3 (1, 5)	4 (1, 10)	8 (3, 14)	8 (3, 13)
	n_unique	11 (6, 16)	2 (1, 5)	4 (0, 10)	7 (3, 13)	7 (2, 12)
	post_p	NA (NA, NA)	0.28 (0.16, 0.42)	0.65 (0.39, 0.89)	0.72 (0.45, 0.92)	0.71 (0.43, 0.92)
	rate	0.088 (0.051, 0.151)	0.188 (0.093, 0.614)	0.04 (0.007, 0.12)	0.037 (0.018, 0.074)	0.039 (0.017, 0.083)
+—	graduation	0	15	1	4	6
	futility	0	0	0	0	0
	max_n	0	0	0	0	0
	n	20 (14, 28)	8 (3, 18)	9 (4, 20)	8 (3, 18)	8 (3, 17)
	n_unique	19 (13, 26)	7 (2, 16)	9 (4, 18)	7 (2, 16)	7 (2, 16)
	post_p	NA (NA, NA)	0.37 (0.15, 0.79)	0.39 (0.14, 0.78)	0.41 (0.16, 0.81)	0.42 (0.18, 0.81)
	rate	0.147 (0.108, 0.205)	0.182 (0.113, 0.43)	0.177 (0.122, 0.365)	0.174 (0.11, 0.391)	0.178 (0.108, 0.407)
+–+	graduation	0	127	167	14	14
	futility	0	0	0	0	0
	max_n	0	0	28	3	0
	n	18 (11, 24)	4 (2, 10)	14 (4, 22)	5 (2, 11)	5 (2, 11)
	n_unique	16 (10, 22)	4 (2, 9)	13 (4, 20)	4 (2, 10)	4 (2, 10)
	post_p	NA (NA, NA)	0.25 (0.1, 0.51)	0.95 (0.72, 1)	0.25 (0.11, 0.48)	0.25 (0.11, 0.51)
	rate	0.087 (0.059, 0.133)	0.192 (0.101, 0.496)	0.039 (0.02, 0.066)	0.181 (0.1, 0.449)	0.176 (0.103, 0.502)
+-+-	graduation	0	273	29	9	15
	futility	0	0	0	0	0
	max_n	0	0	42	14	8
	n	16 (11, 22)	6 (1, 15)	7 (3, 15)	7 (3, 15)	7 (3, 15)
	n_unique	15 (9, 21)	5 (1, 14)	6 (3, 14)	6 (2, 14)	6 (2, 14)
	post_p	NA (NA, NA)	0.41 (0.2, 0.78)	0.39 (0.16, 0.77)	0.41 (0.18, 0.8)	0.42 (0.19, 0.79)
	rate	0.146 (0.105, 0.206)	0.183 (0.113, 0.441)	0.186 (0.116, 0.416)	0.178 (0.109, 0.452)	0.177 (0.107, 0.41)
+-++	graduation	0	320	183	19	23
	futility	0	0	0	0	0
	max_n	0	0	65	16	8
	n	17 (12, 23)	4 (2, 9)	13 (3, 22)	5 (2, 12)	5 (2, 11)
	n_unique	16 (10, 21)	3 (1, 8)	12 (3, 20)	4 (2, 11)	4 (2, 10)
	post_p	NA (NA, NA)	0.27 (0.12, 0.5)	0.95 (0.72, 1)	0.25 (0.11, 0.49)	0.26 (0.11, 0.48)
	rate	0.087 (0.056, 0.132)	0.176 (0.101, 0.441)	0.037 (0.019, 0.069)	0.17 (0.099, 0.384)	0.176 (0.102, 0.403)
++–	graduation	0	66	9	94	99
	futility	0	0	0	0	0
	max_n	0	0	0	0	0
	n	11 (7, 17)	3 (1, 6)	3 (1, 7)	8 (3, 15)	8 (3, 15)
	n_unique	10 (6, 15)	3 (1, 6)	3 (1, 6)	8 (3, 13)	8 (3, 14)
	post_p	NA (NA, NA)	0.32 (0.16, 0.53)	0.32 (0.18, 0.54)	0.9 (0.57, 0.99)	0.91 (0.58, 0.99)
	rate	0.153 (0.095, 0.232)	0.195 (0.094, 0.565)	0.187 (0.095, 0.58)	0.037 (0.017, 0.091)	0.037 (0.017, 0.084)
++-+	graduation	0	158	174	103	107
	futility	0	0	0	0	0
	max_n	0	0	28	3	0
	n	11 (7, 16)	3 (1, 6)	4 (1, 10)	8 (3, 14)	8 (3, 13)
	n_unique	10 (6, 15)	3 (1, 5)	4 (1, 9)	7 (3, 13)	7 (2, 13)
	post_p	NA (NA, NA)	0.27 (0.12, 0.42)	0.67 (0.38, 0.9)	0.73 (0.42, 0.93)	0.74 (0.38, 0.94)
	rate	0.088 (0.054, 0.154)	0.184 (0.093, 0.455)	0.04 (0.014, 0.106)	0.039 (0.016, 0.086)	0.038 (0.016, 0.088)
+++-	graduation	0	297	37	95	103
	futility	0	0	0	0	0
	max_n	0	0	42	13	8
	n	12 (7, 16)	3 (1, 6)	3 (1, 6)	8 (3, 15)	8 (3, 14)
	n_unique	10 (6, 15)	2 (1, 5)	3 (1, 6)	8 (2, 13)	8 (3, 13)
	post_p	NA (NA, NA)	0.33 (0.17, 0.55)	0.32 (0.17, 0.53)	0.89 (0.58, 0.99)	0.9 (0.59, 0.99)
	rate	0.146 (0.097, 0.226)	0.201 (0.09, 0.553)	0.183 (0.095, 0.501)	0.039 (0.017, 0.083)	0.037 (0.015, 0.083)
++++	graduation	0	330	190	104	111
	futility	0	0	0	0	0
	max_n	0	0	65	15	8
	n	11 (7, 16)	3 (1, 5)	4 (0, 10)	8 (3, 14)	7 (2, 14)
	n_unique	10 (6, 15)	3 (1, 5)	4 (0, 10)	7 (2, 13)	7 (2, 13)
	post_p	NA (NA, NA)	0.28 (0.14, 0.42)	0.66 (0.38, 0.87)	0.74 (0.41, 0.94)	0.73 (0.4, 0.93)
	rate	0.089 (0.054, 0.154)	0.183 (0.098, 0.58)	0.041 (0.009, 0.114)	0.036 (0.016, 0.08)	0.037 (0.015, 0.09)

Median results over time

Signatures:

Posterior probabilities

Randomization probabilities

PFS rates

Subgroup combinations:

Posterior probabilities

Randomization probabilities

PFS rates

Median results at stop

By signature

Graduation:

signature	var	Hormone_therapies	Taxel_therapies	Carboplatin	Niraparib
all	count	11	1	4	5
	time_stop	5 (4, 7)	5 (5, 5)	6 (6, 7)	6 (5, 10)
	n_trt	29 (25, 45)	25 (25, 25)	27 (26, 28)	28 (26, 48)
	n_control	58 (48, 73)	57 (57, 57)	70 (61, 96)	65 (52, 102)
	post_p	0.92 (0.86, 0.97)	0.9 (0.9, 0.9)	0.99 (0.98, 1)	0.96 (0.95, 0.98)
	order	1 (1, 1)	1 (1, 1)	1 (1, 1)	1 (1, 1)
TP53- & AR-	count	291	1	1	1
	time_stop	10 (7, 23)	15 (15, 15)	12 (12, 12)	11 (11, 11)
	n_trt	35 (26, 95)	32 (32, 32)	35 (35, 35)	29 (29, 29)
	n_control	44 (30, 107)	58 (58, 58)	52 (52, 52)	46 (46, 46)
	post_p	0.95 (0.87, 1)	0.9 (0.9, 0.9)	0.86 (0.86, 0.86)	0.89 (0.89, 0.89)
	order	1 (1, 2)	3 (3, 3)	3 (3, 3)	2 (2, 2)
TP53+	count	2	27	5	8
	time_stop	11 (10, 12)	10 (8, 15)	16 (9, 19)	15 (9, 20)
	n_trt	30 (26, 33)	29 (26, 44)	29 (25, 47)	32 (28, 54)
	n_control	46 (41, 51)	42 (33, 65)	59 (47, 74)	62 (37, 97)
	post_p	0.9 (0.89, 0.92)	0.98 (0.92, 1)	0.98 (0.96, 0.98)	0.96 (0.91, 1)
	order	2 (2, 2)	1 (1, 2)	1 (1, 2)	1 (1, 3.3)
DRD+	count			89	93
	time_stop			23 (13, 35)	25 (12, 34)
	n_trt			56 (26, 91)	57 (26, 85)
	n_control			65 (27, 105)	73 (28, 108)
	post_p			1 (0.98, 1)	1 (0.98, 1)
	order			2 (1, 3)	2 (1, 3)
TEfus+	count		166	2
	time_stop		14 (9, 33)	16 (10, 21)
	n_trt		43 (26, 110)	40 (30, 51)
	n_control		57 (30, 140)	62 (44, 79)
	post_p		0.99 (0.92, 1)	0.98 (0.97, 1)
	order		2 (1, 2)	1 (1, 1)

Futility:

signature	var	Hormone_therapies	Taxel_therapies	Carboplatin	Niraparib
all	count	4			1
	time_stop	4 (3, 6)			12 (12, 12)
	n_trt	30 (25, 44)			51 (51, 51)
	n_control	52 (36, 62)			129 (129, 129)
	post_p	0.03 (0, 0.22)			0.06 (0.06, 0.06)
	order	1 (1, 1)			1 (1, 1)
TP53- & AR-	count	1	84	71	79
	time_stop	13 (13, 13)	22 (13, 32)	17 (11, 28)	17 (14, 25)
	n_trt	46 (46, 46)	29 (25, 48)	30 (25, 48)	30 (25, 54)
	n_control	58 (58, 58)	101 (56, 161)	74 (51, 137)	80 (58, 128)
	post_p	0.16 (0.16, 0.16)	0.08 (0.01, 0.21)	0.14 (0.02, 0.25)	0.12 (0.01, 0.27)
	order	1 (1, 1)	1 (1, 2)	1 (1, 2)	1 (1, 2.2)
TP53+	count	256	1		3
	time_stop	22 (13, 32)	10 (10, 10)		14 (12, 17)
	n_trt	43 (27, 68)	34 (34, 34)		32 (27, 34)
	n_control	107 (58, 170)	36 (36, 36)		79 (57, 81)
	post_p	0.02 (0, 0.1)	0.24 (0.24, 0.24)		0.1 (0.08, 0.14)
	order	1 (1, 2)	1 (1, 1)		2 (1.2, 2)
DRD+	count	51	8	1
	time_stop	28 (21, 34)	26 (20, 33)	14 (14, 14)
	n_trt	28 (25, 40)	28 (25, 44)	26 (26, 26)
	n_control	79 (53, 105)	72 (50, 115)	33 (33, 33)
	post_p	0.04 (0.01, 0.15)	0.1 (0.02, 0.23)	0.13 (0.13, 0.13)
	order	2 (1, 3)	2 (1, 3)	1 (1, 1)
TEfus+	count	112		8	8
	time_stop	22 (15, 32)		18 (12, 29)	14 (11, 24)
	n_trt	33 (25, 55)		34 (30, 41)	30 (27, 45)
	n_control	86 (54, 142)		76 (47, 127)	45 (33, 106)
	post_p	0.03 (0, 0.1)		0.13 (0.07, 0.18)	0.17 (0.06, 0.21)
	order	2 (1, 3)		1 (1, 2)	1 (1, 2)

By subgroup combinations

Graduation:

signature	treatment	var	—-	—+	–+-	–++	-+–	-+-+	-++-	-+++	+—	+–+	+-+-	+-++	++–	++-+	+++-	++++
all	Hormone_therapies	count	11	11	11	11	11	11	11	11	11	11	11	11	11	11	11	11
		time	5 (4, 7)	5 (4, 7)	5 (4, 7)	5 (4, 7)	5 (4, 7)	5 (4, 7)	5 (4, 7)	5 (4, 7)	5 (4, 7)	5 (4, 7)	5 (4, 7)	5 (4, 7)	5 (4, 7)	5 (4, 7)	5 (4, 7)	5 (4, 7)
		n	15 (13, 19)	2 (1, 5)	8 (4, 9)	1 (0, 4)	0 (0, 0)	0 (0, 1)	0 (0, 1)	0 (0, 0)	1 (0, 2)	1 (0, 2)	1 (0, 2)	0 (0, 3)	0 (0, 1)	0 (0, 0)	0 (0, 1)	0 (0, 1)
		post_p	0.81 (0.7, 0.89)	0.53 (0.52, 0.6)	0.61 (0.52, 0.7)	0.52 (0.51, 0.55)	0.53 (0.53, 0.53)	0.53 (0.52, 0.55)	0.53 (0.52, 0.55)	NA (NA, NA)	0.55 (0.52, 0.66)	0.54 (0.52, 0.57)	0.54 (0.51, 0.6)	0.54 (0.54, 0.57)	0.52 (0.51, 0.54)	NA (NA, NA)	0.52 (0.51, 0.52)	NA (NA, NA)
		r_prob	0.44 (0.44, 0.44)	0.35 (0.35, 0.35)	0.33 (0.33, 0.33)	0.18 (0.18, 0.18)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0.18 (0.18, 0.18)	0.18 (0.18, 0.18)	0.12 (0.12, 0.12)	0.12 (0.12, 0.12)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)
		rate	0.012 (0, 0.033)	0 (0, 0)	0 (0, 0.092)	0 (0, 0.08)	0 (0, 0)	0 (0, 0)	0 (0, 0)	NA (NA, NA)	0 (0, 0.127)	0 (0, 0.101)	0 (0, 0)	0 (0, 0)	0 (0, 0)	NA (NA, NA)	0 (0, 0)	0.603 (0.121, 1.085)
	Taxel_therapies	count	1	1	1	1	1	1	1	1	1	1	1	1	1	1	1	1
		time	5 (5, 5)	5 (5, 5)	5 (5, 5)	5 (5, 5)	5 (5, 5)	5 (5, 5)	5 (5, 5)	5 (5, 5)	5 (5, 5)	5 (5, 5)	5 (5, 5)	5 (5, 5)	5 (5, 5)	5 (5, 5)	5 (5, 5)	5 (5, 5)
		n	9 (9, 9)	1 (1, 1)	0 (0, 0)	3 (3, 3)	0 (0, 0)	0 (0, 0)	0 (0, 0)	1 (1, 1)	4 (4, 4)	1 (1, 1)	0 (0, 0)	6 (6, 6)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)
		post_p	0.5 (0.5, 0.5)	0.53 (0.53, 0.53)	NA (NA, NA)	0.6 (0.6, 0.6)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	0.51 (0.51, 0.51)	0.59 (0.59, 0.59)	0.55 (0.55, 0.55)	NA (NA, NA)	0.62 (0.62, 0.62)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)
		r_prob	0.11 (0.11, 0.11)	0.29 (0.29, 0.29)	0.17 (0.17, 0.17)	0.41 (0.41, 0.41)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0.41 (0.41, 0.41)	0.41 (0.41, 0.41)	0.37 (0.37, 0.37)	0.37 (0.37, 0.37)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)
		rate	0.102 (0.102, 0.102)	0 (0, 0)	NA (NA, NA)	0 (0, 0)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	0 (0, 0)	0.081 (0.081, 0.081)	0 (0, 0)	NA (NA, NA)	0 (0, 0)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)
	Carboplatin	count	4	4	4	4	4	4	4	4	4	4	4	4	4	4	4	4
		time	6 (6, 7)	6 (6, 7)	6 (6, 7)	6 (6, 7)	6 (6, 7)	6 (6, 7)	6 (6, 7)	6 (6, 7)	6 (6, 7)	6 (6, 7)	6 (6, 7)	6 (6, 7)	6 (6, 7)	6 (6, 7)	6 (6, 7)	6 (6, 7)
		n	3 (3, 3)	0 (0, 1)	4 (3, 5)	2 (0, 3)	2 (1, 3)	4 (2, 4)	2 (0, 3)	2 (1, 4)	1 (0, 1)	0 (0, 2)	2 (0, 2)	0 (0, 1)	2 (1, 3)	0 (0, 1)	1 (0, 2)	2 (0, 4)
		post_p	0.61 (0.58, 0.65)	0.51 (0.51, 0.51)	0.59 (0.51, 0.75)	0.52 (0.52, 0.62)	0.53 (0.53, 0.58)	0.55 (0.52, 0.58)	0.6 (0.54, 0.66)	0.57 (0.53, 0.61)	0.58 (0.55, 0.59)	0.56 (0.55, 0.58)	0.57 (0.54, 0.61)	0.52 (0.51, 0.53)	0.53 (0.5, 0.56)	0.51 (0.51, 0.51)	0.54 (0.53, 0.56)	0.53 (0.53, 0.55)
		r_prob	0 (0, 0)	0 (0, 0)	0.08 (0.08, 0.08)	0 (0, 0)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0 (0, 0)	0 (0, 0)	0.06 (0.06, 0.06)	0.06 (0.06, 0.06)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)
		rate	0 (0, 0)	0 (0, 0)	0.085 (0.019, 0.171)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)
	Niraparib	count	5	5	5	5	5	5	5	5	5	5	5	5	5	5	5	5
		time	6 (5, 10)	6 (5, 10)	6 (5, 10)	6 (5, 10)	6 (5, 10)	6 (5, 10)	6 (5, 10)	6 (5, 10)	6 (5, 10)	6 (5, 10)	6 (5, 10)	6 (5, 10)	6 (5, 10)	6 (5, 10)	6 (5, 10)	6 (5, 10)
		n	4 (1, 10)	2 (0, 2)	6 (3, 12)	1 (0, 2)	2 (0, 4)	2 (1, 7)	0 (0, 2)	0 (0, 3)	0 (0, 2)	0 (0, 2)	1 (0, 5)	0 (0, 0)	2 (0, 5)	0 (0, 2)	3 (1, 6)	3 (0, 5)
		post_p	0.56 (0.53, 0.59)	0.52 (0.5, 0.55)	0.73 (0.6, 0.8)	0.52 (0.52, 0.53)	0.56 (0.52, 0.59)	0.52 (0.51, 0.58)	0.56 (0.56, 0.56)	0.63 (0.62, 0.64)	0.63 (0.6, 0.66)	0.61 (0.61, 0.61)	0.6 (0.58, 0.61)	NA (NA, NA)	0.54 (0.51, 0.57)	0.55 (0.53, 0.57)	0.56 (0.52, 0.64)	0.53 (0.52, 0.53)
		r_prob	0 (0, 0)	0 (0, 0)	0.08 (0.08, 0.08)	0 (0, 0)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0 (0, 0)	0 (0, 0)	0.06 (0.06, 0.06)	0.06 (0.06, 0.06)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)
		rate	0 (0, 0.099)	0 (0, 0)	0.072 (0, 0.118)	0 (0, 0)	0 (0, 0.089)	0 (0, 0.019)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0.077)	NA (NA, NA)	0 (0, 0.024)	0 (0, 0)	0 (0, 0.052)	0 (0, 0)
TP53- & AR-	Hormone_therapies	count	291	291			291	291
		time	10 (7, 23)	10 (7, 23)			10 (7, 23)	10 (7, 23)
		n	28 (20, 75)	4 (2, 11)			2 (0, 6)	2 (0, 5)
		post_p	0.95 (0.82, 1)	0.58 (0.51, 0.77)			0.56 (0.51, 0.76)	0.54 (0.51, 0.7)
		r_prob	0.44 (0.44, 0.44)	0.35 (0.35, 0.35)			0 (0, 0)	0 (0, 0)
		rate	0.038 (0.018, 0.054)	0 (0, 0.064)			0 (0, 0.053)	0 (0, 0.048)
	Taxel_therapies	count	1	1			1	1
		time	15 (15, 15)	15 (15, 15)			15 (15, 15)	15 (15, 15)
		n	25 (25, 25)	3 (3, 3)			1 (1, 1)	3 (3, 3)
		post_p	0.72 (0.72, 0.72)	0.74 (0.74, 0.74)			0.57 (0.57, 0.57)	0.54 (0.54, 0.54)
		r_prob	0.11 (0.11, 0.11)	0.29 (0.29, 0.29)			0 (0, 0)	0 (0, 0)
		rate	0.066 (0.066, 0.066)	0.038 (0.038, 0.038)			0 (0, 0)	0 (0, 0)
	Carboplatin	count	1	1			1	1
		time	12 (12, 12)	12 (12, 12)			12 (12, 12)	12 (12, 12)
		n	21 (21, 21)	5 (5, 5)			7 (7, 7)	2 (2, 2)
		post_p	0.7 (0.7, 0.7)	0.55 (0.55, 0.55)			0.72 (0.72, 0.72)	0.52 (0.52, 0.52)
		r_prob	0 (0, 0)	0 (0, 0)			0.33 (0.33, 0.33)	0.33 (0.33, 0.33)
		rate	0.09 (0.09, 0.09)	0.077 (0.077, 0.077)			0.057 (0.057, 0.057)	0 (0, 0)
	Niraparib	count	1	1			1	1
		time	11 (11, 11)	11 (11, 11)			11 (11, 11)	11 (11, 11)
		n	18 (18, 18)	5 (5, 5)			3 (3, 3)	3 (3, 3)
		post_p	0.81 (0.81, 0.81)	0.52 (0.52, 0.52)			0.58 (0.58, 0.58)	0.55 (0.55, 0.55)
		r_prob	0 (0, 0)	0 (0, 0)			0.33 (0.33, 0.33)	0.33 (0.33, 0.33)
		rate	0.041 (0.041, 0.041)	0.096 (0.096, 0.096)			0.04 (0.04, 0.04)	0 (0, 0)
TP53+	Hormone_therapies	count			2	2			2	2			2	2			2	2
		time			11 (10, 12)	11 (10, 12)			11 (10, 12)	11 (10, 12)			11 (10, 12)	11 (10, 12)			11 (10, 12)	11 (10, 12)
		n			17 (12, 22)	4 (4, 5)			0 (0, 1)	0 (0, 0)			2 (1, 4)	3 (2, 4)			0 (0, 1)	2 (1, 2)
		post_p			0.84 (0.81, 0.88)	0.7 (0.67, 0.74)			0.54 (0.54, 0.54)	NA (NA, NA)			0.76 (0.76, 0.76)	0.53 (0.52, 0.54)			0.5 (0.5, 0.5)	0.54 (0.52, 0.57)
		r_prob			0.33 (0.33, 0.33)	0.18 (0.18, 0.18)			0 (0, 0)	0 (0, 0)			0.12 (0.12, 0.12)	0.12 (0.12, 0.12)			0 (0, 0)	0 (0, 0)
		rate			0.069 (0.067, 0.072)	0.054 (0.043, 0.065)			0 (0, 0)	NA (NA, NA)			0.036 (0.007, 0.065)	0.06 (0.012, 0.108)			0 (0, 0)	0 (0, 0)
	Taxel_therapies	count			27	27			27	27			27	27			27	27
		time			10 (8, 15)	10 (8, 15)			10 (8, 15)	10 (8, 15)			10 (8, 15)	10 (8, 15)			10 (8, 15)	10 (8, 15)
		n			9 (5, 14)	11 (8, 18)			0 (0, 2)	1 (0, 4)			3 (1, 5)	4 (2, 6)			0 (0, 2)	1 (0, 3)
		post_p			0.75 (0.63, 0.84)	0.77 (0.71, 0.97)			0.53 (0.5, 0.6)	0.56 (0.52, 0.65)			0.54 (0.51, 0.68)	0.64 (0.52, 0.8)			0.54 (0.53, 0.59)	0.53 (0.51, 0.6)
		r_prob			0.17 (0.17, 0.17)	0.41 (0.41, 0.41)			0 (0, 0)	0 (0, 0)			0.37 (0.37, 0.37)	0.37 (0.37, 0.37)			0 (0, 0)	0 (0, 0)
		rate			0.089 (0.049, 0.135)	0.026 (0.006, 0.053)			0 (0, 0.114)	0 (0, 0.012)			0.096 (0, 0.204)	0 (0, 0.094)			0 (0, 0.064)	0 (0, 0.108)
	Carboplatin	count			5	5			5	5			5	5			5	5
		time			16 (9, 19)	16 (9, 19)			16 (9, 19)	16 (9, 19)			16 (9, 19)	16 (9, 19)			16 (9, 19)	16 (9, 19)
		n			11 (9, 20)	4 (1, 5)			5 (1, 11)	4 (3, 5)			4 (2, 4)	0 (0, 2)			3 (1, 4)	2 (1, 4)
		post_p			0.86 (0.71, 0.9)	0.52 (0.51, 0.59)			0.69 (0.53, 0.82)	0.57 (0.53, 0.67)			0.56 (0.51, 0.71)	0.53 (0.51, 0.54)			0.55 (0.51, 0.62)	0.59 (0.54, 0.6)
		r_prob			0.08 (0.08, 0.08)	0 (0, 0)			0.33 (0.33, 0.33)	0.33 (0.33, 0.33)			0.06 (0.06, 0.06)	0.06 (0.06, 0.06)			0.33 (0.33, 0.33)	0.33 (0.33, 0.33)
		rate			0.07 (0.038, 0.092)	0.098 (0, 0.134)			0 (0, 0.033)	0.029 (0.011, 0.037)			0.105 (0.06, 0.2)	0.134 (0.099, 0.169)			0.033 (0.009, 0.066)	0.026 (0, 0.053)
	Niraparib	count			8	8			8	8			8	8			8	8
		time			15 (9, 20)	15 (9, 20)			15 (9, 20)	15 (9, 20)			15 (9, 20)	15 (9, 20)			15 (9, 20)	15 (9, 20)
		n			13 (9, 24)	4 (2, 5)			4 (1, 9)	3 (1, 4)			4 (3, 9)	1 (0, 2)			4 (2, 5)	2 (1, 4)
		post_p			0.79 (0.75, 0.88)	0.54 (0.52, 0.58)			0.58 (0.51, 0.82)	0.53 (0.51, 0.65)			0.6 (0.51, 0.91)	0.53 (0.52, 0.58)			0.61 (0.51, 0.67)	0.56 (0.53, 0.65)
		r_prob			0.08 (0.08, 0.08)	0 (0, 0)			0.33 (0.33, 0.33)	0.33 (0.33, 0.33)			0.06 (0.06, 0.06)	0.06 (0.06, 0.06)			0.33 (0.33, 0.33)	0.33 (0.33, 0.33)
		rate			0.102 (0.047, 0.124)	0.074 (0.026, 0.122)			0 (0, 0.067)	0.033 (0, 0.077)			0.118 (0.088, 0.198)	0 (0, 0.067)			0.019 (0, 0.122)	0 (0, 0.039)
DRD+	Carboplatin	count					89	89	89	89					89	89	89	89
		time					23 (13, 35)	23 (13, 35)	23 (13, 35)	23 (13, 35)					23 (13, 35)	23 (13, 35)	23 (13, 35)	23 (13, 35)
		n					10 (4, 19)	8 (3, 21)	5 (2, 11)	5 (2, 11)					6 (2, 12)	5 (3, 11)	4 (2, 11)	4 (2, 12)
		post_p					0.8 (0.56, 0.96)	0.73 (0.52, 0.86)	0.79 (0.55, 0.96)	0.71 (0.53, 0.91)					0.76 (0.54, 0.96)	0.71 (0.55, 0.88)	0.73 (0.54, 0.97)	0.69 (0.52, 0.91)
		r_prob					0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)					0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)
		rate					0.026 (0, 0.046)	0.026 (0, 0.046)	0.032 (0, 0.061)	0.03 (0, 0.052)					0.03 (0, 0.076)	0.028 (0, 0.053)	0.035 (0, 0.075)	0.021 (0, 0.053)
	Niraparib	count					93	93	93	93					93	93	93	93
		time					25 (12, 34)	25 (12, 34)	25 (12, 34)	25 (12, 34)					25 (12, 34)	25 (12, 34)	25 (12, 34)	25 (12, 34)
		n					9 (3, 17)	10 (4, 17)	5 (2, 13)	5 (2, 11)					5 (2, 11)	5 (2, 12)	5 (2, 11)	5 (2, 11)
		post_p					0.78 (0.55, 0.92)	0.73 (0.55, 0.88)	0.77 (0.53, 0.98)	0.71 (0.54, 0.86)					0.78 (0.54, 0.95)	0.71 (0.52, 0.95)	0.78 (0.57, 0.95)	0.69 (0.52, 0.91)
		r_prob					0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)					0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)
		rate					0.032 (0, 0.057)	0.025 (0, 0.043)	0.031 (0, 0.071)	0.023 (0, 0.062)					0.033 (0, 0.067)	0.025 (0, 0.06)	0.028 (0, 0.069)	0.019 (0, 0.06)
TEfus+	Taxel_therapies	count		166		166		166		166		166		166		166		166
		time		14 (9, 33)		14 (9, 33)		14 (9, 33)		14 (9, 33)		14 (9, 33)		14 (9, 33)		14 (9, 33)		14 (9, 33)
		n		5 (2, 17)		17 (11, 40)		3 (1, 10)		2 (0, 6)		5 (3, 16)		5 (2, 14)		2 (0, 5)		2 (0, 6)
		post_p		0.68 (0.52, 0.87)		0.91 (0.75, 1)		0.56 (0.51, 0.78)		0.57 (0.51, 0.78)		0.73 (0.53, 0.96)		0.74 (0.55, 0.98)		0.57 (0.51, 0.82)		0.57 (0.51, 0.75)
		r_prob		0.29 (0.29, 0.29)		0.41 (0.41, 0.41)		0 (0, 0)		0 (0, 0)		0.41 (0.41, 0.41)		0.37 (0.37, 0.37)		0 (0, 0)		0 (0, 0)
		rate		0.027 (0, 0.059)		0.034 (0.014, 0.056)		0 (0, 0.05)		0 (0, 0.069)		0.038 (0, 0.073)		0.025 (0, 0.066)		0 (0, 0.046)		0 (0, 0.061)
	Carboplatin	count		2		2		2		2		2		2		2		2
		time		16 (10, 21)		16 (10, 21)		16 (10, 21)		16 (10, 21)		16 (10, 21)		16 (10, 21)		16 (10, 21)		16 (10, 21)
		n		2 (0, 4)		6 (4, 8)		8 (6, 9)		8 (3, 13)		3 (2, 4)		2 (1, 2)		6 (4, 8)		6 (4, 8)
		post_p		0.51 (0.51, 0.51)		0.65 (0.54, 0.76)		0.83 (0.75, 0.91)		0.76 (0.6, 0.91)		0.59 (0.55, 0.63)		0.51 (0.51, 0.52)		0.68 (0.59, 0.76)		0.75 (0.67, 0.82)
		r_prob		0 (0, 0)		0 (0, 0)		0.33 (0.33, 0.33)		0.33 (0.33, 0.33)		0 (0, 0)		0.06 (0.06, 0.06)		0.33 (0.33, 0.33)		0.33 (0.33, 0.33)
		rate		0 (0, 0)		0.065 (0.049, 0.08)		0.004 (0.001, 0.008)		0.011 (0.002, 0.019)		0.042 (0.008, 0.075)		0.041 (0.008, 0.073)		0 (0, 0)		0.013 (0.003, 0.023)

Futility:

signature	treatment	var	—-	—+	–+-	–++	-+–	-+-+	-++-	-+++	+—	+–+	+-+-	+-++	++–	++-+	+++-	++++
all	Hormone_therapies	count	4	4	4	4	4	4	4	4	4	4	4	4	4	4	4	4
		time	4 (3, 6)	4 (3, 6)	4 (3, 6)	4 (3, 6)	4 (3, 6)	4 (3, 6)	4 (3, 6)	4 (3, 6)	4 (3, 6)	4 (3, 6)	4 (3, 6)	4 (3, 6)	4 (3, 6)	4 (3, 6)	4 (3, 6)	4 (3, 6)
		n	12 (9, 16)	2 (1, 5)	12 (8, 13)	2 (0, 5)	0 (0, 3)	0 (0, 0)	0 (0, 0)	0 (0, 1)	0 (0, 3)	0 (0, 2)	0 (0, 1)	0 (0, 1)	0 (0, 0)	0 (0, 0)	0 (0, 1)	0 (0, 1)
		post_p	0.35 (0.33, 0.45)	0.42 (0.39, 0.44)	0.36 (0.31, 0.4)	0.3 (0.25, 0.41)	0.43 (0.43, 0.43)	NA (NA, NA)	NA (NA, NA)	0.44 (0.44, 0.44)	0.42 (0.42, 0.42)	0.41 (0.41, 0.42)	0.43 (0.41, 0.44)	0.48 (0.48, 0.48)	NA (NA, NA)	NA (NA, NA)	0.43 (0.43, 0.43)	0.44 (0.44, 0.44)
		r_prob	0.44 (0.44, 0.44)	0.35 (0.35, 0.35)	0.33 (0.33, 0.33)	0.18 (0.18, 0.18)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0.18 (0.18, 0.18)	0.18 (0.18, 0.18)	0.12 (0.12, 0.12)	0.12 (0.12, 0.12)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)
		rate	0.126 (0.113, 0.155)	0.19 (0.032, 0.284)	0.203 (0.157, 0.256)	0.408 (0.277, 1.764)	0.132 (0.132, 0.132)	NA (NA, NA)	NA (NA, NA)	0.733 (0.733, 0.733)	0.185 (0.185, 0.185)	0.931 (0.346, 1.517)	0.408 (0.36, 0.456)	0.597 (0.119, 1.074)	NA (NA, NA)	NA (NA, NA)	42.436 (42.436, 42.436)	0.409 (0.409, 0.409)
	Niraparib	count	1	1	1	1	1	1	1	1	1	1	1	1	1	1	1	1
		time	12 (12, 12)	12 (12, 12)	12 (12, 12)	12 (12, 12)	12 (12, 12)	12 (12, 12)	12 (12, 12)	12 (12, 12)	12 (12, 12)	12 (12, 12)	12 (12, 12)	12 (12, 12)	12 (12, 12)	12 (12, 12)	12 (12, 12)	12 (12, 12)
		n	4 (4, 4)	1 (1, 1)	10 (10, 10)	2 (2, 2)	3 (3, 3)	2 (2, 2)	4 (4, 4)	6 (6, 6)	4 (4, 4)	3 (3, 3)	3 (3, 3)	6 (6, 6)	0 (0, 0)	0 (0, 0)	0 (0, 0)	3 (3, 3)
		post_p	0.2 (0.2, 0.2)	0.36 (0.36, 0.36)	0.14 (0.14, 0.14)	0.49 (0.49, 0.49)	0.36 (0.36, 0.36)	0.35 (0.35, 0.35)	0.37 (0.37, 0.37)	0.45 (0.45, 0.45)	0.37 (0.37, 0.37)	0.4 (0.4, 0.4)	0.39 (0.39, 0.39)	0.48 (0.48, 0.48)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	0.49 (0.49, 0.49)
		r_prob	0 (0, 0)	0 (0, 0)	0.08 (0.08, 0.08)	0 (0, 0)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0 (0, 0)	0 (0, 0)	0.06 (0.06, 0.06)	0.06 (0.06, 0.06)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)
		rate	0.289 (0.289, 0.289)	0.24 (0.24, 0.24)	0.246 (0.246, 0.246)	0.1 (0.1, 0.1)	0.087 (0.087, 0.087)	0.361 (0.361, 0.361)	0.13 (0.13, 0.13)	0.072 (0.072, 0.072)	0.209 (0.209, 0.209)	0.162 (0.162, 0.162)	0.214 (0.214, 0.214)	0.087 (0.087, 0.087)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	0.06 (0.06, 0.06)
TP53- & AR-	Hormone_therapies	count	1	1			1	1
		time	13 (13, 13)	13 (13, 13)			13 (13, 13)	13 (13, 13)
		n	41 (41, 41)	5 (5, 5)			0 (0, 0)	0 (0, 0)
		post_p	0.42 (0.42, 0.42)	0.2 (0.2, 0.2)			NA (NA, NA)	NA (NA, NA)
		r_prob	0.44 (0.44, 0.44)	0.35 (0.35, 0.35)			0 (0, 0)	0 (0, 0)
		rate	0.079 (0.079, 0.079)	0.128 (0.128, 0.128)			NA (NA, NA)	NA (NA, NA)
	Taxel_therapies	count	84	84			84	84
		time	22 (13, 32)	22 (13, 32)			22 (13, 32)	22 (13, 32)
		n	13 (8, 30)	6 (2, 12)			3 (2, 7)	5 (1, 9)
		post_p	0.1 (0.02, 0.31)	0.43 (0.29, 0.49)			0.26 (0.14, 0.44)	0.42 (0.25, 0.49)
		r_prob	0.11 (0.11, 0.11)	0.29 (0.29, 0.29)			0 (0, 0)	0 (0, 0)
		rate	0.164 (0.113, 0.268)	0.075 (0.051, 0.162)			0.205 (0.094, 0.653)	0.066 (0.038, 0.152)
	Carboplatin	count	71	71			71	71
		time	17 (11, 28)	17 (11, 28)			17 (11, 28)	17 (11, 28)
		n	13 (7, 27)	4 (2, 9)			6 (2, 9)	6 (3, 11)
		post_p	0.11 (0.02, 0.32)	0.31 (0.09, 0.43)			0.45 (0.27, 0.49)	0.44 (0.29, 0.49)
		r_prob	0 (0, 0)	0 (0, 0)			0.33 (0.33, 0.33)	0.33 (0.33, 0.33)
		rate	0.166 (0.118, 0.328)	0.2 (0.104, 0.483)			0.072 (0.046, 0.257)	0.051 (0.029, 0.085)
	Niraparib	count	79	79			79	79
		time	17 (14, 25)	17 (14, 25)			17 (14, 25)	17 (14, 25)
		n	15 (9, 37)	4 (2, 7)			5 (2, 11)	6 (3, 11)
		post_p	0.13 (0.02, 0.33)	0.32 (0.12, 0.44)			0.45 (0.34, 0.49)	0.44 (0.26, 0.49)
		r_prob	0 (0, 0)	0 (0, 0)			0.33 (0.33, 0.33)	0.33 (0.33, 0.33)
		rate	0.158 (0.115, 0.244)	0.173 (0.086, 0.598)			0.076 (0.046, 0.185)	0.06 (0.032, 0.126)
TP53+	Hormone_therapies	count			256	256			256	256			256	256			256	256
		time			22 (13, 32)	22 (13, 32)			22 (13, 32)	22 (13, 32)			22 (13, 32)	22 (13, 32)			22 (13, 32)	22 (13, 32)
		n			14 (7, 36)	6 (4, 14)			2 (1, 5)	2 (1, 5)			4 (1, 10)	3 (2, 7)			3 (1, 5)	2 (1, 5)
		post_p			0.3 (0.08, 0.47)	0.23 (0.08, 0.42)			0.38 (0.23, 0.48)	0.37 (0.2, 0.46)			0.39 (0.23, 0.47)	0.36 (0.16, 0.47)			0.38 (0.21, 0.47)	0.36 (0.2, 0.46)
		r_prob			0.33 (0.33, 0.33)	0.18 (0.18, 0.18)			0 (0, 0)	0 (0, 0)			0.12 (0.12, 0.12)	0.12 (0.12, 0.12)			0 (0, 0)	0 (0, 0)
		rate			0.184 (0.141, 0.293)	0.159 (0.106, 0.305)			0.2 (0.099, 0.713)	0.191 (0.084, 0.717)			0.22 (0.136, 0.548)	0.193 (0.108, 0.47)			0.215 (0.097, 0.645)	0.19 (0.082, 0.616)
	Taxel_therapies	count			1	1			1	1			1	1			1	1
		time			10 (10, 10)	10 (10, 10)			10 (10, 10)	10 (10, 10)			10 (10, 10)	10 (10, 10)			10 (10, 10)	10 (10, 10)
		n			11 (11, 11)	15 (15, 15)			0 (0, 0)	1 (1, 1)			4 (4, 4)	3 (3, 3)			0 (0, 0)	0 (0, 0)
		post_p			0.41 (0.41, 0.41)	0.32 (0.32, 0.32)			NA (NA, NA)	0.49 (0.49, 0.49)			0.44 (0.44, 0.44)	0.5 (0.5, 0.5)			NA (NA, NA)	NA (NA, NA)
		r_prob			0.17 (0.17, 0.17)	0.41 (0.41, 0.41)			0 (0, 0)	0 (0, 0)			0.37 (0.37, 0.37)	0.37 (0.37, 0.37)			0 (0, 0)	0 (0, 0)
		rate			0.148 (0.148, 0.148)	0.08 (0.08, 0.08)			NA (NA, NA)	0 (0, 0)			0.17 (0.17, 0.17)	0.123 (0.123, 0.123)			NA (NA, NA)	NA (NA, NA)
	Niraparib	count			3	3			3	3			3	3			3	3
		time			14 (12, 17)	14 (12, 17)			14 (12, 17)	14 (12, 17)			14 (12, 17)	14 (12, 17)			14 (12, 17)	14 (12, 17)
		n			9 (8, 10)	3 (2, 4)			1 (1, 3)	1 (0, 5)			4 (3, 7)	6 (3, 8)			0 (0, 2)	3 (3, 3)
		post_p			0.14 (0.14, 0.38)	0.28 (0.18, 0.45)			0.4 (0.37, 0.44)	0.47 (0.45, 0.49)			0.39 (0.39, 0.42)	0.33 (0.29, 0.45)			0.42 (0.42, 0.42)	0.44 (0.34, 0.48)
		r_prob			0.08 (0.08, 0.08)	0 (0, 0)			0.33 (0.33, 0.33)	0.33 (0.33, 0.33)			0.06 (0.06, 0.06)	0.06 (0.06, 0.06)			0.33 (0.33, 0.33)	0.33 (0.33, 0.33)
		rate			0.246 (0.203, 0.306)	0.198 (0.119, 0.311)			0.376 (0.18, 0.466)	0.036 (0.007, 0.065)			0.223 (0.216, 0.282)	0.087 (0.082, 1.361)			0.077 (0.077, 0.077)	0.06 (0.034, 0.14)
DRD+	Hormone_therapies	count					51	51	51	51					51	51	51	51
		time					28 (21, 34)	28 (21, 34)	28 (21, 34)	28 (21, 34)					28 (21, 34)	28 (21, 34)	28 (21, 34)	28 (21, 34)
		n					4 (0, 9)	4 (0, 11)	3 (1, 5)	3 (1, 5)					3 (1, 7)	3 (2, 7)	3 (1, 7)	3 (1, 6)
		post_p					0.41 (0.26, 0.48)	0.39 (0.26, 0.48)	0.31 (0.19, 0.43)	0.32 (0.16, 0.46)					0.34 (0.2, 0.46)	0.29 (0.17, 0.46)	0.38 (0.24, 0.48)	0.31 (0.14, 0.44)
		r_prob					0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)					0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)
		rate					0.088 (0.051, 0.163)	0.066 (0.046, 0.157)	0.206 (0.122, 0.619)	0.19 (0.079, 0.854)					0.21 (0.107, 0.6)	0.16 (0.084, 0.448)	0.18 (0.091, 0.767)	0.17 (0.087, 0.579)
	Taxel_therapies	count					8	8	8	8					8	8	8	8
		time					26 (20, 33)	26 (20, 33)	26 (20, 33)	26 (20, 33)					26 (20, 33)	26 (20, 33)	26 (20, 33)	26 (20, 33)
		n					4 (3, 12)	6 (4, 8)	4 (2, 6)	2 (1, 6)					2 (1, 5)	3 (1, 7)	2 (2, 5)	4 (0, 8)
		post_p					0.27 (0.12, 0.39)	0.36 (0.25, 0.41)	0.3 (0.18, 0.4)	0.46 (0.27, 0.48)					0.33 (0.29, 0.43)	0.37 (0.36, 0.45)	0.37 (0.27, 0.47)	0.41 (0.38, 0.48)
		r_prob					0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)					0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)
		rate					0.154 (0.106, 0.185)	0.069 (0.052, 0.105)	0.218 (0.142, 1.413)	0.124 (0.057, 0.261)					0.233 (0.144, 0.887)	0.097 (0.057, 0.185)	0.245 (0.109, 3.523)	0.078 (0.061, 0.15)
	Carboplatin	count					1	1	1	1					1	1	1	1
		time					14 (14, 14)	14 (14, 14)	14 (14, 14)	14 (14, 14)					14 (14, 14)	14 (14, 14)	14 (14, 14)	14 (14, 14)
		n					8 (8, 8)	4 (4, 4)	5 (5, 5)	2 (2, 2)					4 (4, 4)	0 (0, 0)	1 (1, 1)	2 (2, 2)
		post_p					0.38 (0.38, 0.38)	0.38 (0.38, 0.38)	0.32 (0.32, 0.32)	0.38 (0.38, 0.38)					0.44 (0.44, 0.44)	NA (NA, NA)	0.48 (0.48, 0.48)	0.46 (0.46, 0.46)
		r_prob					0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)					0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)
		rate					0.074 (0.074, 0.074)	0.143 (0.143, 0.143)	0.104 (0.104, 0.104)	0.152 (0.152, 0.152)					0.119 (0.119, 0.119)	NA (NA, NA)	0.107 (0.107, 0.107)	0.068 (0.068, 0.068)
TEfus+	Hormone_therapies	count		112		112		112		112		112		112		112		112
		time		22 (15, 32)		22 (15, 32)		22 (15, 32)		22 (15, 32)		22 (15, 32)		22 (15, 32)		22 (15, 32)		22 (15, 32)
		n		5 (2, 13)		7 (4, 15)		4 (0, 9)		2 (1, 5)		3 (2, 8)		3 (2, 6)		3 (1, 5)		3 (1, 5)
		post_p		0.43 (0.27, 0.49)		0.21 (0.07, 0.41)		0.42 (0.28, 0.48)		0.37 (0.23, 0.47)		0.33 (0.16, 0.43)		0.33 (0.14, 0.47)		0.37 (0.18, 0.47)		0.36 (0.21, 0.46)
		r_prob		0.35 (0.35, 0.35)		0.18 (0.18, 0.18)		0 (0, 0)		0 (0, 0)		0.18 (0.18, 0.18)		0.12 (0.12, 0.12)		0 (0, 0)		0 (0, 0)
		rate		0.073 (0.045, 0.173)		0.168 (0.113, 0.377)		0.068 (0.042, 0.157)		0.148 (0.074, 0.589)		0.215 (0.113, 0.63)		0.177 (0.111, 0.443)		0.177 (0.067, 0.549)		0.177 (0.083, 0.672)
	Carboplatin	count		8		8		8		8		8		8		8		8
		time		18 (12, 29)		18 (12, 29)		18 (12, 29)		18 (12, 29)		18 (12, 29)		18 (12, 29)		18 (12, 29)		18 (12, 29)
		n		6 (3, 8)		8 (5, 9)		6 (5, 8)		4 (1, 6)		2 (1, 5)		3 (2, 5)		2 (1, 6)		4 (2, 6)
		post_p		0.25 (0.08, 0.4)		0.29 (0.13, 0.39)		0.43 (0.32, 0.48)		0.45 (0.35, 0.48)		0.34 (0.27, 0.43)		0.37 (0.21, 0.49)		0.39 (0.29, 0.47)		0.43 (0.34, 0.47)
		r_prob		0 (0, 0)		0 (0, 0)		0.33 (0.33, 0.33)		0.33 (0.33, 0.33)		0 (0, 0)		0.06 (0.06, 0.06)		0.33 (0.33, 0.33)		0.33 (0.33, 0.33)
		rate		0.276 (0.108, 0.339)		0.146 (0.13, 0.325)		0.051 (0.043, 0.076)		0.062 (0.048, 0.132)		0.309 (0.157, 0.441)		0.191 (0.123, 0.349)		0.071 (0.027, 0.233)		0.069 (0.051, 0.3)
	Niraparib	count		8		8		8		8		8		8		8		8
		time		14 (11, 24)		14 (11, 24)		14 (11, 24)		14 (11, 24)		14 (11, 24)		14 (11, 24)		14 (11, 24)		14 (11, 24)
		n		3 (2, 4)		7 (4, 12)		7 (4, 11)		4 (2, 6)		2 (1, 5)		4 (3, 5)		2 (1, 6)		2 (2, 4)
		post_p		0.38 (0.28, 0.47)		0.21 (0.13, 0.42)		0.43 (0.4, 0.48)		0.48 (0.41, 0.49)		0.42 (0.3, 0.47)		0.43 (0.31, 0.46)		0.44 (0.33, 0.48)		0.43 (0.34, 0.48)
		r_prob		0 (0, 0)		0 (0, 0)		0.33 (0.33, 0.33)		0.33 (0.33, 0.33)		0 (0, 0)		0.06 (0.06, 0.06)		0.33 (0.33, 0.33)		0.33 (0.33, 0.33)
		rate		0.163 (0.103, 0.222)		0.172 (0.118, 0.371)		0.042 (0.036, 0.077)		0.072 (0.019, 0.086)		0.223 (0.131, 1.554)		0.125 (0.091, 0.239)		0.077 (0.028, 0.271)		0.122 (0.055, 0.319)