Several treatments more effective in distinctive signatures: (Hormone therapies, TP53- & AR-); (Taxel therapies, TEfus+); (Carboplatin and Niraparib, DRD+)
| signature | var | Other | Hormone_therapies | Taxel_therapies | Carboplatin | Niraparib |
|---|---|---|---|---|---|---|
| all | param | scale = 0.112, shape = 1.05 | scale = 0.112, shape = 1.05 | scale = 0.114, shape = 1.05 | scale = 0.124, shape = 1.05 | scale = 0.124, shape = 1.05 |
| summary | mean = 8.8, median = 6.3 | mean = 8.7, median = 6.3 | mean = 8.6, median = 6.2 | mean = 7.9, median = 5.7 | mean = 7.9, median = 5.7 | |
| effect | af = 1, hr = 1 | af = 0.99, hr = 1.01 | af = 0.98, hr = 1.02 | af = 0.9, hr = 1.12 | af = 0.9, hr = 1.12 | |
| TP53- & AR- | param | scale = 0.112, shape = 1.05 | scale = 0.043, shape = 1.05 | scale = 0.128, shape = 1.05 | scale = 0.127, shape = 1.05 | scale = 0.127, shape = 1.05 |
| summary | mean = 8.8, median = 6.3 | mean = 22.6, median = 16.3 | mean = 7.7, median = 5.5 | mean = 7.7, median = 5.5 | mean = 7.7, median = 5.5 | |
| effect | af = 1, hr = 1 | af = 2.58, hr = 0.37 | af = 0.87, hr = 1.15 | af = 0.88, hr = 1.15 | af = 0.88, hr = 1.15 | |
| TP53+ | param | scale = 0.112, shape = 1.05 | scale = 0.157, shape = 1.05 | scale = 0.105, shape = 1.05 | scale = 0.125, shape = 1.05 | scale = 0.125, shape = 1.05 |
| summary | mean = 8.8, median = 6.3 | mean = 6.3, median = 4.5 | mean = 9.3, median = 6.7 | mean = 7.8, median = 5.6 | mean = 7.8, median = 5.6 | |
| effect | af = 1, hr = 1 | af = 0.71, hr = 1.43 | af = 1.06, hr = 0.94 | af = 0.89, hr = 1.13 | af = 0.89, hr = 1.13 | |
| DRD+ | param | scale = 0.112, shape = 1.05 | scale = 0.117, shape = 1.05 | scale = 0.099, shape = 1.05 | scale = 0.037, shape = 1.05 | scale = 0.037, shape = 1.05 |
| summary | mean = 8.8, median = 6.3 | mean = 8.4, median = 6 | mean = 9.9, median = 7.1 | mean = 26.6, median = 19.1 | mean = 26.6, median = 19.1 | |
| effect | af = 1, hr = 1 | af = 0.95, hr = 1.05 | af = 1.13, hr = 0.88 | af = 3.03, hr = 0.31 | af = 3.03, hr = 0.31 | |
| TEfus+ | param | scale = 0.112, shape = 1.05 | scale = 0.127, shape = 1.05 | scale = 0.039, shape = 1.05 | scale = 0.112, shape = 1.05 | scale = 0.112, shape = 1.05 |
| summary | mean = 8.8, median = 6.3 | mean = 7.7, median = 5.6 | mean = 25, median = 18 | mean = 8.7, median = 6.3 | mean = 8.7, median = 6.3 | |
| effect | af = 1, hr = 1 | af = 0.88, hr = 1.14 | af = 2.85, hr = 0.33 | af = 0.99, hr = 1.01 | af = 0.99, hr = 1.01 |
| subtype | var | Other | Hormone_therapies | Taxel_therapies | Carboplatin | Niraparib |
|---|---|---|---|---|---|---|
| —- | param | scale = 0.112, shape = 1.05 | scale = 0.043, shape = 1.05 | scale = 0.157, shape = 1.05 | scale = 0.157, shape = 1.05 | scale = 0.157, shape = 1.05 |
| summary | mean = 8.8, median = 6.3 | mean = 22.6, median = 16.3 | mean = 6.3, median = 4.5 | mean = 6.3, median = 4.5 | mean = 6.3, median = 4.5 | |
| effect | af = 1, hr = 1 | af = 2.58, hr = 0.37 | af = 0.71, hr = 1.43 | af = 0.71, hr = 1.43 | af = 0.71, hr = 1.43 | |
| —+ | param | scale = 0.112, shape = 1.05 | scale = 0.043, shape = 1.05 | scale = 0.039, shape = 1.05 | scale = 0.157, shape = 1.05 | scale = 0.157, shape = 1.05 |
| summary | mean = 8.8, median = 6.3 | mean = 22.6, median = 16.3 | mean = 25, median = 18 | mean = 6.3, median = 4.5 | mean = 6.3, median = 4.5 | |
| effect | af = 1, hr = 1 | af = 2.58, hr = 0.37 | af = 2.85, hr = 0.33 | af = 0.71, hr = 1.43 | af = 0.71, hr = 1.43 | |
| –+- | param | scale = 0.112, shape = 1.05 | scale = 0.157, shape = 1.05 | scale = 0.157, shape = 1.05 | scale = 0.157, shape = 1.05 | scale = 0.157, shape = 1.05 |
| summary | mean = 8.8, median = 6.3 | mean = 6.3, median = 4.5 | mean = 6.3, median = 4.5 | mean = 6.3, median = 4.5 | mean = 6.3, median = 4.5 | |
| effect | af = 1, hr = 1 | af = 0.71, hr = 1.43 | af = 0.71, hr = 1.43 | af = 0.71, hr = 1.43 | af = 0.71, hr = 1.43 | |
| –++ | param | scale = 0.112, shape = 1.05 | scale = 0.157, shape = 1.05 | scale = 0.039, shape = 1.05 | scale = 0.157, shape = 1.05 | scale = 0.157, shape = 1.05 |
| summary | mean = 8.8, median = 6.3 | mean = 6.3, median = 4.5 | mean = 25, median = 18 | mean = 6.3, median = 4.5 | mean = 6.3, median = 4.5 | |
| effect | af = 1, hr = 1 | af = 0.71, hr = 1.43 | af = 2.85, hr = 0.33 | af = 0.71, hr = 1.43 | af = 0.71, hr = 1.43 | |
| -+– | param | scale = 0.112, shape = 1.05 | scale = 0.043, shape = 1.05 | scale = 0.157, shape = 1.05 | scale = 0.037, shape = 1.05 | scale = 0.037, shape = 1.05 |
| summary | mean = 8.8, median = 6.3 | mean = 22.6, median = 16.3 | mean = 6.3, median = 4.5 | mean = 26.6, median = 19.1 | mean = 26.6, median = 19.1 | |
| effect | af = 1, hr = 1 | af = 2.58, hr = 0.37 | af = 0.71, hr = 1.43 | af = 3.03, hr = 0.31 | af = 3.03, hr = 0.31 | |
| -+-+ | param | scale = 0.112, shape = 1.05 | scale = 0.043, shape = 1.05 | scale = 0.039, shape = 1.05 | scale = 0.037, shape = 1.05 | scale = 0.037, shape = 1.05 |
| summary | mean = 8.8, median = 6.3 | mean = 22.6, median = 16.3 | mean = 25, median = 18 | mean = 26.6, median = 19.1 | mean = 26.6, median = 19.1 | |
| effect | af = 1, hr = 1 | af = 2.58, hr = 0.37 | af = 2.85, hr = 0.33 | af = 3.03, hr = 0.31 | af = 3.03, hr = 0.31 | |
| -++- | param | scale = 0.112, shape = 1.05 | scale = 0.157, shape = 1.05 | scale = 0.157, shape = 1.05 | scale = 0.037, shape = 1.05 | scale = 0.037, shape = 1.05 |
| summary | mean = 8.8, median = 6.3 | mean = 6.3, median = 4.5 | mean = 6.3, median = 4.5 | mean = 26.6, median = 19.1 | mean = 26.6, median = 19.1 | |
| effect | af = 1, hr = 1 | af = 0.71, hr = 1.43 | af = 0.71, hr = 1.43 | af = 3.03, hr = 0.31 | af = 3.03, hr = 0.31 | |
| -+++ | param | scale = 0.112, shape = 1.05 | scale = 0.157, shape = 1.05 | scale = 0.039, shape = 1.05 | scale = 0.037, shape = 1.05 | scale = 0.037, shape = 1.05 |
| summary | mean = 8.8, median = 6.3 | mean = 6.3, median = 4.5 | mean = 25, median = 18 | mean = 26.6, median = 19.1 | mean = 26.6, median = 19.1 | |
| effect | af = 1, hr = 1 | af = 0.71, hr = 1.43 | af = 2.85, hr = 0.33 | af = 3.03, hr = 0.31 | af = 3.03, hr = 0.31 | |
| +— | param | scale = 0.112, shape = 1.05 | scale = 0.157, shape = 1.05 | scale = 0.157, shape = 1.05 | scale = 0.157, shape = 1.05 | scale = 0.157, shape = 1.05 |
| summary | mean = 8.8, median = 6.3 | mean = 6.3, median = 4.5 | mean = 6.3, median = 4.5 | mean = 6.3, median = 4.5 | mean = 6.3, median = 4.5 | |
| effect | af = 1, hr = 1 | af = 0.71, hr = 1.43 | af = 0.71, hr = 1.43 | af = 0.71, hr = 1.43 | af = 0.71, hr = 1.43 | |
| +–+ | param | scale = 0.112, shape = 1.05 | scale = 0.157, shape = 1.05 | scale = 0.039, shape = 1.05 | scale = 0.157, shape = 1.05 | scale = 0.157, shape = 1.05 |
| summary | mean = 8.8, median = 6.3 | mean = 6.3, median = 4.5 | mean = 25, median = 18 | mean = 6.3, median = 4.5 | mean = 6.3, median = 4.5 | |
| effect | af = 1, hr = 1 | af = 0.71, hr = 1.43 | af = 2.85, hr = 0.33 | af = 0.71, hr = 1.43 | af = 0.71, hr = 1.43 | |
| +-+- | param | scale = 0.112, shape = 1.05 | scale = 0.157, shape = 1.05 | scale = 0.157, shape = 1.05 | scale = 0.157, shape = 1.05 | scale = 0.157, shape = 1.05 |
| summary | mean = 8.8, median = 6.3 | mean = 6.3, median = 4.5 | mean = 6.3, median = 4.5 | mean = 6.3, median = 4.5 | mean = 6.3, median = 4.5 | |
| effect | af = 1, hr = 1 | af = 0.71, hr = 1.43 | af = 0.71, hr = 1.43 | af = 0.71, hr = 1.43 | af = 0.71, hr = 1.43 | |
| +-++ | param | scale = 0.112, shape = 1.05 | scale = 0.157, shape = 1.05 | scale = 0.039, shape = 1.05 | scale = 0.157, shape = 1.05 | scale = 0.157, shape = 1.05 |
| summary | mean = 8.8, median = 6.3 | mean = 6.3, median = 4.5 | mean = 25, median = 18 | mean = 6.3, median = 4.5 | mean = 6.3, median = 4.5 | |
| effect | af = 1, hr = 1 | af = 0.71, hr = 1.43 | af = 2.85, hr = 0.33 | af = 0.71, hr = 1.43 | af = 0.71, hr = 1.43 | |
| ++– | param | scale = 0.112, shape = 1.05 | scale = 0.157, shape = 1.05 | scale = 0.157, shape = 1.05 | scale = 0.037, shape = 1.05 | scale = 0.037, shape = 1.05 |
| summary | mean = 8.8, median = 6.3 | mean = 6.3, median = 4.5 | mean = 6.3, median = 4.5 | mean = 26.6, median = 19.1 | mean = 26.6, median = 19.1 | |
| effect | af = 1, hr = 1 | af = 0.71, hr = 1.43 | af = 0.71, hr = 1.43 | af = 3.03, hr = 0.31 | af = 3.03, hr = 0.31 | |
| ++-+ | param | scale = 0.112, shape = 1.05 | scale = 0.157, shape = 1.05 | scale = 0.039, shape = 1.05 | scale = 0.037, shape = 1.05 | scale = 0.037, shape = 1.05 |
| summary | mean = 8.8, median = 6.3 | mean = 6.3, median = 4.5 | mean = 25, median = 18 | mean = 26.6, median = 19.1 | mean = 26.6, median = 19.1 | |
| effect | af = 1, hr = 1 | af = 0.71, hr = 1.43 | af = 2.85, hr = 0.33 | af = 3.03, hr = 0.31 | af = 3.03, hr = 0.31 | |
| +++- | param | scale = 0.112, shape = 1.05 | scale = 0.157, shape = 1.05 | scale = 0.157, shape = 1.05 | scale = 0.037, shape = 1.05 | scale = 0.037, shape = 1.05 |
| summary | mean = 8.8, median = 6.3 | mean = 6.3, median = 4.5 | mean = 6.3, median = 4.5 | mean = 26.6, median = 19.1 | mean = 26.6, median = 19.1 | |
| effect | af = 1, hr = 1 | af = 0.71, hr = 1.43 | af = 0.71, hr = 1.43 | af = 3.03, hr = 0.31 | af = 3.03, hr = 0.31 | |
| ++++ | param | scale = 0.112, shape = 1.05 | scale = 0.157, shape = 1.05 | scale = 0.039, shape = 1.05 | scale = 0.037, shape = 1.05 | scale = 0.037, shape = 1.05 |
| summary | mean = 8.8, median = 6.3 | mean = 6.3, median = 4.5 | mean = 25, median = 18 | mean = 26.6, median = 19.1 | mean = 26.6, median = 19.1 | |
| effect | af = 1, hr = 1 | af = 0.71, hr = 1.43 | af = 2.85, hr = 0.33 | af = 3.03, hr = 0.31 | af = 3.03, hr = 0.31 |
|
|
|
|
|
|
The overall error was 0.082.
The corresponding errors separate for the different treatments were:
Hormone_therapies Taxel_therapies Carboplatin Niraparib
0.020 0.034 0.014 0.016
The overall power was 0.808.
The corresponding power separate for the different treatments were:
Hormone_therapies Taxel_therapies Carboplatin Niraparib
0.582 0.332 0.178 0.186
| signature | var | Control | Hormone_therapies | Taxel_therapies | Carboplatin | Niraparib |
|---|---|---|---|---|---|---|
| all | graduation | 0 | 11 | 1 | 4 | 5 |
| futility | 0 | 4 | 0 | 0 | 1 | |
| max_n | 0 | 0 | 0 | 0 | 0 | |
| n | 446 (420, 478) | 160 (85, 246) | 195 (111, 262) | 176 (130, 258) | 173 (121, 255) | |
| n_unique | 408 (385, 439) | 148 (77, 233) | 178 (98, 242) | 159 (117, 242) | 158 (112, 237) | |
| time_trial | 36 (36, 36) | 36 (36, 36) | 36 (36, 36) | 36 (36, 36) | 36 (36, 36) | |
| time_stop | NA (NA, NA) | 5 (3, 7) | 5 (5, 5) | 6 (6, 7) | 8 (5, 11) | |
| post_p | NA (NA, NA) | 0.95 (0.17, 1) | 0.99 (0.49, 1) | 0.92 (0.25, 1) | 0.9 (0.24, 1) | |
| rate | 0.094 (0.087, 0.101) | 0.077 (0.061, 0.102) | 0.072 (0.06, 0.091) | 0.079 (0.065, 0.098) | 0.08 (0.066, 0.098) | |
| TP53- & AR- | graduation | 0 | 291 | 1 | 1 | 1 |
| futility | 0 | 1 | 84 | 71 | 79 | |
| max_n | 0 | 143 | 11 | 33 | 40 | |
| n | 193 (173, 213) | 66 (26, 153) | 44 (25, 117) | 51 (28, 138) | 51 (28, 141) | |
| n_unique | 178 (160, 200) | 64 (25, 146) | 40 (21, 111) | 46 (26, 132) | 46 (25, 134) | |
| time_trial | 36 (36, 36) | 20 (8, 36) | 36 (23, 36) | 36 (21, 36) | 36 (19, 36) | |
| time_stop | NA (NA, NA) | 10 (7, 23) | 22 (13, 32) | 16 (11, 28) | 17 (14, 25) | |
| post_p | NA (NA, NA) | 1 (0.97, 1) | 0.32 (0.01, 0.9) | 0.5 (0, 0.96) | 0.41 (0, 0.93) | |
| rate | 0.075 (0.066, 0.085) | 0.042 (0.034, 0.051) | 0.083 (0.055, 0.12) | 0.075 (0.052, 0.113) | 0.078 (0.052, 0.116) | |
| TP53+ | graduation | 0 | 2 | 27 | 5 | 8 |
| futility | 0 | 256 | 1 | 0 | 3 | |
| max_n | 0 | 0 | 42 | 14 | 8 | |
| n | 193 (173, 216) | 56 (28, 93) | 110 (52, 145) | 84 (57, 123) | 82 (53, 120) | |
| n_unique | 176 (156, 197) | 51 (26, 86) | 100 (48, 135) | 77 (51, 115) | 75 (48, 112) | |
| time_trial | 36 (36, 36) | 34 (15, 36) | 36 (36, 36) | 36 (36, 36) | 36 (36, 36) | |
| time_stop | NA (NA, NA) | 22 (13, 32) | 10 (8, 15) | 16 (9, 19) | 14 (9, 18) | |
| post_p | NA (NA, NA) | 0.02 (0, 0.14) | 1 (0.9, 1) | 0.95 (0.54, 1) | 0.95 (0.54, 1) | |
| rate | 0.113 (0.102, 0.126) | 0.161 (0.137, 0.198) | 0.067 (0.051, 0.089) | 0.085 (0.065, 0.109) | 0.085 (0.063, 0.108) | |
| DRD+ | graduation | 0 | 0 | 0 | 89 | 93 |
| futility | 0 | 51 | 8 | 1 | 0 | |
| max_n | 0 | 0 | 0 | 0 | 0 | |
| n | 111 (96, 128) | 27 (17, 44) | 38 (21, 57) | 79 (50, 101) | 76 (46, 99) | |
| n_unique | 100 (86, 116) | 24 (15, 40) | 34 (19, 52) | 72 (45, 93) | 70 (42, 91) | |
| time_trial | 36 (36, 36) | 36 (35, 36) | 36 (36, 36) | 36 (26, 36) | 36 (27, 36) | |
| time_stop | NA (NA, NA) | 28 (21, 34) | 26 (20, 33) | 23 (13, 35) | 25 (12, 34) | |
| post_p | NA (NA, NA) | 0.23 (0.02, 0.79) | 0.76 (0.22, 0.98) | 1 (1, 1) | 1 (1, 1) | |
| rate | 0.091 (0.078, 0.107) | 0.103 (0.069, 0.159) | 0.07 (0.05, 0.099) | 0.036 (0.029, 0.044) | 0.036 (0.029, 0.045) | |
| TEfus+ | graduation | 0 | 0 | 166 | 2 | 0 |
| futility | 0 | 112 | 0 | 8 | 8 | |
| max_n | 0 | 0 | 28 | 3 | 0 | |
| n | 161 (143, 179) | 39 (24, 61) | 114 (31, 144) | 63 (43, 102) | 62 (41, 95) | |
| n_unique | 147 (130, 164) | 35 (22, 56) | 104 (28, 133) | 58 (39, 95) | 57 (38, 87) | |
| time_trial | 36 (36, 36) | 36 (21, 36) | 36 (11, 36) | 36 (36, 36) | 36 (36, 36) | |
| time_stop | NA (NA, NA) | 22 (15, 32) | 14 (9, 33) | 18 (12, 27) | 14 (11, 24) | |
| post_p | NA (NA, NA) | 0.08 (0, 0.55) | 1 (0.99, 1) | 0.69 (0.12, 0.96) | 0.7 (0.15, 0.97) | |
| rate | 0.076 (0.066, 0.087) | 0.101 (0.075, 0.138) | 0.038 (0.031, 0.046) | 0.068 (0.052, 0.088) | 0.067 (0.05, 0.09) |
| subtype | var | Control | Hormone_therapies | Taxel_therapies | Carboplatin | Niraparib |
|---|---|---|---|---|---|---|
| —- | graduation | 0 | 306 | 86 | 76 | 86 |
| futility | 0 | 0 | 0 | 0 | 0 | |
| max_n | 0 | 143 | 11 | 33 | 40 | |
| n | 129 (114, 144) | 53 (21, 124) | 15 (8, 85) | 15 (7, 95) | 16 (7, 99) | |
| n_unique | 120 (106, 136) | 50 (20, 120) | 13 (7, 82) | 13 (6, 90) | 14 (6, 94) | |
| post_p | NA (NA, NA) | 1 (0.99, 1) | 0.04 (0, 0.15) | 0.04 (0, 0.13) | 0.03 (0, 0.15) | |
| rate | 0.083 (0.072, 0.097) | 0.042 (0.033, 0.052) | 0.165 (0.128, 0.268) | 0.17 (0.132, 0.299) | 0.169 (0.132, 0.281) | |
| —+ | graduation | 0 | 344 | 237 | 83 | 92 |
| futility | 0 | 0 | 0 | 0 | 0 | |
| max_n | 0 | 139 | 37 | 34 | 40 | |
| n | 22 (15, 29) | 5 (2, 18) | 14 (3, 25) | 6 (3, 15) | 5 (2, 14) | |
| n_unique | 20 (14, 27) | 5 (2, 17) | 13 (3, 23) | 5 (2, 14) | 5 (2, 13) | |
| post_p | NA (NA, NA) | 0.68 (0.33, 0.92) | 0.81 (0.39, 0.97) | 0.14 (0.03, 0.3) | 0.14 (0.03, 0.33) | |
| rate | 0.053 (0.033, 0.081) | 0.044 (0.021, 0.097) | 0.039 (0.021, 0.081) | 0.176 (0.108, 0.36) | 0.176 (0.104, 0.414) | |
| –+- | graduation | 0 | 273 | 29 | 9 | 15 |
| futility | 0 | 0 | 0 | 0 | 0 | |
| max_n | 0 | 0 | 42 | 14 | 8 | |
| n | 65 (52, 80) | 20 (8, 53) | 24 (7, 58) | 23 (6, 56) | 22 (6, 55) | |
| n_unique | 60 (47, 74) | 19 (8, 49) | 22 (7, 55) | 21 (5, 53) | 20 (6, 52) | |
| post_p | NA (NA, NA) | 0.32 (0.09, 0.74) | 0.34 (0.08, 0.79) | 0.29 (0.08, 0.75) | 0.31 (0.08, 0.73) | |
| rate | 0.145 (0.121, 0.172) | 0.169 (0.132, 0.263) | 0.165 (0.13, 0.285) | 0.172 (0.129, 0.315) | 0.173 (0.133, 0.301) | |
| –++ | graduation | 0 | 320 | 183 | 19 | 23 |
| futility | 0 | 0 | 0 | 0 | 0 | |
| max_n | 0 | 0 | 65 | 16 | 8 | |
| n | 48 (38, 58) | 7 (4, 15) | 41 (13, 54) | 8 (4, 33) | 7 (4, 25) | |
| n_unique | 44 (35, 54) | 6 (3, 14) | 38 (12, 50) | 7 (3, 31) | 6 (3, 23) | |
| post_p | NA (NA, NA) | 0.15 (0.05, 0.36) | 1 (0.96, 1) | 0.14 (0.03, 0.35) | 0.14 (0.03, 0.32) | |
| rate | 0.088 (0.068, 0.111) | 0.172 (0.116, 0.304) | 0.038 (0.027, 0.053) | 0.169 (0.121, 0.358) | 0.182 (0.122, 0.333) | |
| -+– | graduation | 0 | 325 | 91 | 160 | 169 |
| futility | 0 | 0 | 0 | 0 | 0 | |
| max_n | 0 | 139 | 11 | 31 | 38 | |
| n | 21 (14, 27) | 3 (0, 12) | 4 (2, 9) | 14 (4, 24) | 13 (4, 23) | |
| n_unique | 19 (12, 25) | 3 (0, 12) | 4 (2, 8) | 13 (4, 23) | 12 (3, 21) | |
| post_p | NA (NA, NA) | 0.68 (0.36, 0.92) | 0.18 (0.07, 0.36) | 0.88 (0.5, 0.99) | 0.84 (0.47, 0.98) | |
| rate | 0.084 (0.058, 0.124) | 0.044 (0.016, 0.104) | 0.185 (0.106, 0.451) | 0.036 (0.02, 0.065) | 0.038 (0.021, 0.074) | |
| -+-+ | graduation | 0 | 352 | 242 | 166 | 175 |
| futility | 0 | 0 | 0 | 0 | 0 | |
| max_n | 0 | 135 | 37 | 32 | 38 | |
| n | 20 (15, 28) | 3 (0, 11) | 7 (2, 18) | 12 (4, 22) | 12 (4, 22) | |
| n_unique | 19 (13, 25) | 3 (0, 11) | 6 (1, 16) | 11 (4, 20) | 11 (4, 20) | |
| post_p | NA (NA, NA) | 0.5 (0.26, 0.77) | 0.55 (0.24, 0.84) | 0.62 (0.31, 0.88) | 0.62 (0.27, 0.9) | |
| rate | 0.053 (0.032, 0.081) | 0.045 (0.017, 0.131) | 0.042 (0.018, 0.095) | 0.038 (0.022, 0.067) | 0.037 (0.02, 0.074) | |
| -++- | graduation | 0 | 297 | 37 | 95 | 103 |
| futility | 0 | 0 | 0 | 0 | 0 | |
| max_n | 0 | 0 | 42 | 13 | 8 | |
| n | 11 (7, 16) | 3 (1, 6) | 3 (1, 6) | 8 (3, 15) | 9 (3, 15) | |
| n_unique | 10 (6, 15) | 3 (0, 5) | 3 (1, 6) | 8 (2, 14) | 8 (2, 14) | |
| post_p | NA (NA, NA) | 0.34 (0.18, 0.55) | 0.32 (0.18, 0.53) | 0.9 (0.65, 0.99) | 0.9 (0.61, 0.99) | |
| rate | 0.149 (0.098, 0.23) | 0.193 (0.092, 0.611) | 0.188 (0.093, 0.53) | 0.036 (0.016, 0.075) | 0.037 (0.016, 0.083) | |
| -+++ | graduation | 0 | 330 | 190 | 104 | 111 |
| futility | 0 | 0 | 0 | 0 | 0 | |
| max_n | 0 | 0 | 65 | 15 | 8 | |
| n | 12 (7, 17) | 3 (1, 5) | 4 (1, 10) | 8 (3, 14) | 8 (3, 13) | |
| n_unique | 11 (6, 16) | 2 (1, 5) | 4 (0, 10) | 7 (3, 13) | 7 (2, 12) | |
| post_p | NA (NA, NA) | 0.28 (0.16, 0.42) | 0.65 (0.39, 0.89) | 0.72 (0.45, 0.92) | 0.71 (0.43, 0.92) | |
| rate | 0.088 (0.051, 0.151) | 0.188 (0.093, 0.614) | 0.04 (0.007, 0.12) | 0.037 (0.018, 0.074) | 0.039 (0.017, 0.083) | |
| +— | graduation | 0 | 15 | 1 | 4 | 6 |
| futility | 0 | 0 | 0 | 0 | 0 | |
| max_n | 0 | 0 | 0 | 0 | 0 | |
| n | 20 (14, 28) | 8 (3, 18) | 9 (4, 20) | 8 (3, 18) | 8 (3, 17) | |
| n_unique | 19 (13, 26) | 7 (2, 16) | 9 (4, 18) | 7 (2, 16) | 7 (2, 16) | |
| post_p | NA (NA, NA) | 0.37 (0.15, 0.79) | 0.39 (0.14, 0.78) | 0.41 (0.16, 0.81) | 0.42 (0.18, 0.81) | |
| rate | 0.147 (0.108, 0.205) | 0.182 (0.113, 0.43) | 0.177 (0.122, 0.365) | 0.174 (0.11, 0.391) | 0.178 (0.108, 0.407) | |
| +–+ | graduation | 0 | 127 | 167 | 14 | 14 |
| futility | 0 | 0 | 0 | 0 | 0 | |
| max_n | 0 | 0 | 28 | 3 | 0 | |
| n | 18 (11, 24) | 4 (2, 10) | 14 (4, 22) | 5 (2, 11) | 5 (2, 11) | |
| n_unique | 16 (10, 22) | 4 (2, 9) | 13 (4, 20) | 4 (2, 10) | 4 (2, 10) | |
| post_p | NA (NA, NA) | 0.25 (0.1, 0.51) | 0.95 (0.72, 1) | 0.25 (0.11, 0.48) | 0.25 (0.11, 0.51) | |
| rate | 0.087 (0.059, 0.133) | 0.192 (0.101, 0.496) | 0.039 (0.02, 0.066) | 0.181 (0.1, 0.449) | 0.176 (0.103, 0.502) | |
| +-+- | graduation | 0 | 273 | 29 | 9 | 15 |
| futility | 0 | 0 | 0 | 0 | 0 | |
| max_n | 0 | 0 | 42 | 14 | 8 | |
| n | 16 (11, 22) | 6 (1, 15) | 7 (3, 15) | 7 (3, 15) | 7 (3, 15) | |
| n_unique | 15 (9, 21) | 5 (1, 14) | 6 (3, 14) | 6 (2, 14) | 6 (2, 14) | |
| post_p | NA (NA, NA) | 0.41 (0.2, 0.78) | 0.39 (0.16, 0.77) | 0.41 (0.18, 0.8) | 0.42 (0.19, 0.79) | |
| rate | 0.146 (0.105, 0.206) | 0.183 (0.113, 0.441) | 0.186 (0.116, 0.416) | 0.178 (0.109, 0.452) | 0.177 (0.107, 0.41) | |
| +-++ | graduation | 0 | 320 | 183 | 19 | 23 |
| futility | 0 | 0 | 0 | 0 | 0 | |
| max_n | 0 | 0 | 65 | 16 | 8 | |
| n | 17 (12, 23) | 4 (2, 9) | 13 (3, 22) | 5 (2, 12) | 5 (2, 11) | |
| n_unique | 16 (10, 21) | 3 (1, 8) | 12 (3, 20) | 4 (2, 11) | 4 (2, 10) | |
| post_p | NA (NA, NA) | 0.27 (0.12, 0.5) | 0.95 (0.72, 1) | 0.25 (0.11, 0.49) | 0.26 (0.11, 0.48) | |
| rate | 0.087 (0.056, 0.132) | 0.176 (0.101, 0.441) | 0.037 (0.019, 0.069) | 0.17 (0.099, 0.384) | 0.176 (0.102, 0.403) | |
| ++– | graduation | 0 | 66 | 9 | 94 | 99 |
| futility | 0 | 0 | 0 | 0 | 0 | |
| max_n | 0 | 0 | 0 | 0 | 0 | |
| n | 11 (7, 17) | 3 (1, 6) | 3 (1, 7) | 8 (3, 15) | 8 (3, 15) | |
| n_unique | 10 (6, 15) | 3 (1, 6) | 3 (1, 6) | 8 (3, 13) | 8 (3, 14) | |
| post_p | NA (NA, NA) | 0.32 (0.16, 0.53) | 0.32 (0.18, 0.54) | 0.9 (0.57, 0.99) | 0.91 (0.58, 0.99) | |
| rate | 0.153 (0.095, 0.232) | 0.195 (0.094, 0.565) | 0.187 (0.095, 0.58) | 0.037 (0.017, 0.091) | 0.037 (0.017, 0.084) | |
| ++-+ | graduation | 0 | 158 | 174 | 103 | 107 |
| futility | 0 | 0 | 0 | 0 | 0 | |
| max_n | 0 | 0 | 28 | 3 | 0 | |
| n | 11 (7, 16) | 3 (1, 6) | 4 (1, 10) | 8 (3, 14) | 8 (3, 13) | |
| n_unique | 10 (6, 15) | 3 (1, 5) | 4 (1, 9) | 7 (3, 13) | 7 (2, 13) | |
| post_p | NA (NA, NA) | 0.27 (0.12, 0.42) | 0.67 (0.38, 0.9) | 0.73 (0.42, 0.93) | 0.74 (0.38, 0.94) | |
| rate | 0.088 (0.054, 0.154) | 0.184 (0.093, 0.455) | 0.04 (0.014, 0.106) | 0.039 (0.016, 0.086) | 0.038 (0.016, 0.088) | |
| +++- | graduation | 0 | 297 | 37 | 95 | 103 |
| futility | 0 | 0 | 0 | 0 | 0 | |
| max_n | 0 | 0 | 42 | 13 | 8 | |
| n | 12 (7, 16) | 3 (1, 6) | 3 (1, 6) | 8 (3, 15) | 8 (3, 14) | |
| n_unique | 10 (6, 15) | 2 (1, 5) | 3 (1, 6) | 8 (2, 13) | 8 (3, 13) | |
| post_p | NA (NA, NA) | 0.33 (0.17, 0.55) | 0.32 (0.17, 0.53) | 0.89 (0.58, 0.99) | 0.9 (0.59, 0.99) | |
| rate | 0.146 (0.097, 0.226) | 0.201 (0.09, 0.553) | 0.183 (0.095, 0.501) | 0.039 (0.017, 0.083) | 0.037 (0.015, 0.083) | |
| ++++ | graduation | 0 | 330 | 190 | 104 | 111 |
| futility | 0 | 0 | 0 | 0 | 0 | |
| max_n | 0 | 0 | 65 | 15 | 8 | |
| n | 11 (7, 16) | 3 (1, 5) | 4 (0, 10) | 8 (3, 14) | 7 (2, 14) | |
| n_unique | 10 (6, 15) | 3 (1, 5) | 4 (0, 10) | 7 (2, 13) | 7 (2, 13) | |
| post_p | NA (NA, NA) | 0.28 (0.14, 0.42) | 0.66 (0.38, 0.87) | 0.74 (0.41, 0.94) | 0.73 (0.4, 0.93) | |
| rate | 0.089 (0.054, 0.154) | 0.183 (0.098, 0.58) | 0.041 (0.009, 0.114) | 0.036 (0.016, 0.08) | 0.037 (0.015, 0.09) |
Posterior probabilities
Randomization probabilities
PFS rates
Posterior probabilities
Randomization probabilities
PFS rates
| signature | var | Hormone_therapies | Taxel_therapies | Carboplatin | Niraparib |
|---|---|---|---|---|---|
| all | count | 11 | 1 | 4 | 5 |
| time_stop | 5 (4, 7) | 5 (5, 5) | 6 (6, 7) | 6 (5, 10) | |
| n_trt | 29 (25, 45) | 25 (25, 25) | 27 (26, 28) | 28 (26, 48) | |
| n_control | 58 (48, 73) | 57 (57, 57) | 70 (61, 96) | 65 (52, 102) | |
| post_p | 0.92 (0.86, 0.97) | 0.9 (0.9, 0.9) | 0.99 (0.98, 1) | 0.96 (0.95, 0.98) | |
| order | 1 (1, 1) | 1 (1, 1) | 1 (1, 1) | 1 (1, 1) | |
| TP53- & AR- | count | 291 | 1 | 1 | 1 |
| time_stop | 10 (7, 23) | 15 (15, 15) | 12 (12, 12) | 11 (11, 11) | |
| n_trt | 35 (26, 95) | 32 (32, 32) | 35 (35, 35) | 29 (29, 29) | |
| n_control | 44 (30, 107) | 58 (58, 58) | 52 (52, 52) | 46 (46, 46) | |
| post_p | 0.95 (0.87, 1) | 0.9 (0.9, 0.9) | 0.86 (0.86, 0.86) | 0.89 (0.89, 0.89) | |
| order | 1 (1, 2) | 3 (3, 3) | 3 (3, 3) | 2 (2, 2) | |
| TP53+ | count | 2 | 27 | 5 | 8 |
| time_stop | 11 (10, 12) | 10 (8, 15) | 16 (9, 19) | 15 (9, 20) | |
| n_trt | 30 (26, 33) | 29 (26, 44) | 29 (25, 47) | 32 (28, 54) | |
| n_control | 46 (41, 51) | 42 (33, 65) | 59 (47, 74) | 62 (37, 97) | |
| post_p | 0.9 (0.89, 0.92) | 0.98 (0.92, 1) | 0.98 (0.96, 0.98) | 0.96 (0.91, 1) | |
| order | 2 (2, 2) | 1 (1, 2) | 1 (1, 2) | 1 (1, 3.3) | |
| DRD+ | count | 89 | 93 | ||
| time_stop | 23 (13, 35) | 25 (12, 34) | |||
| n_trt | 56 (26, 91) | 57 (26, 85) | |||
| n_control | 65 (27, 105) | 73 (28, 108) | |||
| post_p | 1 (0.98, 1) | 1 (0.98, 1) | |||
| order | 2 (1, 3) | 2 (1, 3) | |||
| TEfus+ | count | 166 | 2 | ||
| time_stop | 14 (9, 33) | 16 (10, 21) | |||
| n_trt | 43 (26, 110) | 40 (30, 51) | |||
| n_control | 57 (30, 140) | 62 (44, 79) | |||
| post_p | 0.99 (0.92, 1) | 0.98 (0.97, 1) | |||
| order | 2 (1, 2) | 1 (1, 1) |
| signature | var | Hormone_therapies | Taxel_therapies | Carboplatin | Niraparib |
|---|---|---|---|---|---|
| all | count | 4 | 1 | ||
| time_stop | 4 (3, 6) | 12 (12, 12) | |||
| n_trt | 30 (25, 44) | 51 (51, 51) | |||
| n_control | 52 (36, 62) | 129 (129, 129) | |||
| post_p | 0.03 (0, 0.22) | 0.06 (0.06, 0.06) | |||
| order | 1 (1, 1) | 1 (1, 1) | |||
| TP53- & AR- | count | 1 | 84 | 71 | 79 |
| time_stop | 13 (13, 13) | 22 (13, 32) | 17 (11, 28) | 17 (14, 25) | |
| n_trt | 46 (46, 46) | 29 (25, 48) | 30 (25, 48) | 30 (25, 54) | |
| n_control | 58 (58, 58) | 101 (56, 161) | 74 (51, 137) | 80 (58, 128) | |
| post_p | 0.16 (0.16, 0.16) | 0.08 (0.01, 0.21) | 0.14 (0.02, 0.25) | 0.12 (0.01, 0.27) | |
| order | 1 (1, 1) | 1 (1, 2) | 1 (1, 2) | 1 (1, 2.2) | |
| TP53+ | count | 256 | 1 | 3 | |
| time_stop | 22 (13, 32) | 10 (10, 10) | 14 (12, 17) | ||
| n_trt | 43 (27, 68) | 34 (34, 34) | 32 (27, 34) | ||
| n_control | 107 (58, 170) | 36 (36, 36) | 79 (57, 81) | ||
| post_p | 0.02 (0, 0.1) | 0.24 (0.24, 0.24) | 0.1 (0.08, 0.14) | ||
| order | 1 (1, 2) | 1 (1, 1) | 2 (1.2, 2) | ||
| DRD+ | count | 51 | 8 | 1 | |
| time_stop | 28 (21, 34) | 26 (20, 33) | 14 (14, 14) | ||
| n_trt | 28 (25, 40) | 28 (25, 44) | 26 (26, 26) | ||
| n_control | 79 (53, 105) | 72 (50, 115) | 33 (33, 33) | ||
| post_p | 0.04 (0.01, 0.15) | 0.1 (0.02, 0.23) | 0.13 (0.13, 0.13) | ||
| order | 2 (1, 3) | 2 (1, 3) | 1 (1, 1) | ||
| TEfus+ | count | 112 | 8 | 8 | |
| time_stop | 22 (15, 32) | 18 (12, 29) | 14 (11, 24) | ||
| n_trt | 33 (25, 55) | 34 (30, 41) | 30 (27, 45) | ||
| n_control | 86 (54, 142) | 76 (47, 127) | 45 (33, 106) | ||
| post_p | 0.03 (0, 0.1) | 0.13 (0.07, 0.18) | 0.17 (0.06, 0.21) | ||
| order | 2 (1, 3) | 1 (1, 2) | 1 (1, 2) |
| signature | treatment | var | —- | —+ | –+- | –++ | -+– | -+-+ | -++- | -+++ | +— | +–+ | +-+- | +-++ | ++– | ++-+ | +++- | ++++ |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| all | Hormone_therapies | count | 11 | 11 | 11 | 11 | 11 | 11 | 11 | 11 | 11 | 11 | 11 | 11 | 11 | 11 | 11 | 11 |
| time | 5 (4, 7) | 5 (4, 7) | 5 (4, 7) | 5 (4, 7) | 5 (4, 7) | 5 (4, 7) | 5 (4, 7) | 5 (4, 7) | 5 (4, 7) | 5 (4, 7) | 5 (4, 7) | 5 (4, 7) | 5 (4, 7) | 5 (4, 7) | 5 (4, 7) | 5 (4, 7) | ||
| n | 15 (13, 19) | 2 (1, 5) | 8 (4, 9) | 1 (0, 4) | 0 (0, 0) | 0 (0, 1) | 0 (0, 1) | 0 (0, 0) | 1 (0, 2) | 1 (0, 2) | 1 (0, 2) | 0 (0, 3) | 0 (0, 1) | 0 (0, 0) | 0 (0, 1) | 0 (0, 1) | ||
| post_p | 0.81 (0.7, 0.89) | 0.53 (0.52, 0.6) | 0.61 (0.52, 0.7) | 0.52 (0.51, 0.55) | 0.53 (0.53, 0.53) | 0.53 (0.52, 0.55) | 0.53 (0.52, 0.55) | NA (NA, NA) | 0.55 (0.52, 0.66) | 0.54 (0.52, 0.57) | 0.54 (0.51, 0.6) | 0.54 (0.54, 0.57) | 0.52 (0.51, 0.54) | NA (NA, NA) | 0.52 (0.51, 0.52) | NA (NA, NA) | ||
| r_prob | 0.44 (0.44, 0.44) | 0.35 (0.35, 0.35) | 0.33 (0.33, 0.33) | 0.18 (0.18, 0.18) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0.18 (0.18, 0.18) | 0.18 (0.18, 0.18) | 0.12 (0.12, 0.12) | 0.12 (0.12, 0.12) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | ||
| rate | 0.012 (0, 0.033) | 0 (0, 0) | 0 (0, 0.092) | 0 (0, 0.08) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | NA (NA, NA) | 0 (0, 0.127) | 0 (0, 0.101) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | NA (NA, NA) | 0 (0, 0) | 0.603 (0.121, 1.085) | ||
| Taxel_therapies | count | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | |
| time | 5 (5, 5) | 5 (5, 5) | 5 (5, 5) | 5 (5, 5) | 5 (5, 5) | 5 (5, 5) | 5 (5, 5) | 5 (5, 5) | 5 (5, 5) | 5 (5, 5) | 5 (5, 5) | 5 (5, 5) | 5 (5, 5) | 5 (5, 5) | 5 (5, 5) | 5 (5, 5) | ||
| n | 9 (9, 9) | 1 (1, 1) | 0 (0, 0) | 3 (3, 3) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 1 (1, 1) | 4 (4, 4) | 1 (1, 1) | 0 (0, 0) | 6 (6, 6) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | ||
| post_p | 0.5 (0.5, 0.5) | 0.53 (0.53, 0.53) | NA (NA, NA) | 0.6 (0.6, 0.6) | NA (NA, NA) | NA (NA, NA) | NA (NA, NA) | 0.51 (0.51, 0.51) | 0.59 (0.59, 0.59) | 0.55 (0.55, 0.55) | NA (NA, NA) | 0.62 (0.62, 0.62) | NA (NA, NA) | NA (NA, NA) | NA (NA, NA) | NA (NA, NA) | ||
| r_prob | 0.11 (0.11, 0.11) | 0.29 (0.29, 0.29) | 0.17 (0.17, 0.17) | 0.41 (0.41, 0.41) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0.41 (0.41, 0.41) | 0.41 (0.41, 0.41) | 0.37 (0.37, 0.37) | 0.37 (0.37, 0.37) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | ||
| rate | 0.102 (0.102, 0.102) | 0 (0, 0) | NA (NA, NA) | 0 (0, 0) | NA (NA, NA) | NA (NA, NA) | NA (NA, NA) | 0 (0, 0) | 0.081 (0.081, 0.081) | 0 (0, 0) | NA (NA, NA) | 0 (0, 0) | NA (NA, NA) | NA (NA, NA) | NA (NA, NA) | NA (NA, NA) | ||
| Carboplatin | count | 4 | 4 | 4 | 4 | 4 | 4 | 4 | 4 | 4 | 4 | 4 | 4 | 4 | 4 | 4 | 4 | |
| time | 6 (6, 7) | 6 (6, 7) | 6 (6, 7) | 6 (6, 7) | 6 (6, 7) | 6 (6, 7) | 6 (6, 7) | 6 (6, 7) | 6 (6, 7) | 6 (6, 7) | 6 (6, 7) | 6 (6, 7) | 6 (6, 7) | 6 (6, 7) | 6 (6, 7) | 6 (6, 7) | ||
| n | 3 (3, 3) | 0 (0, 1) | 4 (3, 5) | 2 (0, 3) | 2 (1, 3) | 4 (2, 4) | 2 (0, 3) | 2 (1, 4) | 1 (0, 1) | 0 (0, 2) | 2 (0, 2) | 0 (0, 1) | 2 (1, 3) | 0 (0, 1) | 1 (0, 2) | 2 (0, 4) | ||
| post_p | 0.61 (0.58, 0.65) | 0.51 (0.51, 0.51) | 0.59 (0.51, 0.75) | 0.52 (0.52, 0.62) | 0.53 (0.53, 0.58) | 0.55 (0.52, 0.58) | 0.6 (0.54, 0.66) | 0.57 (0.53, 0.61) | 0.58 (0.55, 0.59) | 0.56 (0.55, 0.58) | 0.57 (0.54, 0.61) | 0.52 (0.51, 0.53) | 0.53 (0.5, 0.56) | 0.51 (0.51, 0.51) | 0.54 (0.53, 0.56) | 0.53 (0.53, 0.55) | ||
| r_prob | 0 (0, 0) | 0 (0, 0) | 0.08 (0.08, 0.08) | 0 (0, 0) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | 0 (0, 0) | 0 (0, 0) | 0.06 (0.06, 0.06) | 0.06 (0.06, 0.06) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | ||
| rate | 0 (0, 0) | 0 (0, 0) | 0.085 (0.019, 0.171) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | ||
| Niraparib | count | 5 | 5 | 5 | 5 | 5 | 5 | 5 | 5 | 5 | 5 | 5 | 5 | 5 | 5 | 5 | 5 | |
| time | 6 (5, 10) | 6 (5, 10) | 6 (5, 10) | 6 (5, 10) | 6 (5, 10) | 6 (5, 10) | 6 (5, 10) | 6 (5, 10) | 6 (5, 10) | 6 (5, 10) | 6 (5, 10) | 6 (5, 10) | 6 (5, 10) | 6 (5, 10) | 6 (5, 10) | 6 (5, 10) | ||
| n | 4 (1, 10) | 2 (0, 2) | 6 (3, 12) | 1 (0, 2) | 2 (0, 4) | 2 (1, 7) | 0 (0, 2) | 0 (0, 3) | 0 (0, 2) | 0 (0, 2) | 1 (0, 5) | 0 (0, 0) | 2 (0, 5) | 0 (0, 2) | 3 (1, 6) | 3 (0, 5) | ||
| post_p | 0.56 (0.53, 0.59) | 0.52 (0.5, 0.55) | 0.73 (0.6, 0.8) | 0.52 (0.52, 0.53) | 0.56 (0.52, 0.59) | 0.52 (0.51, 0.58) | 0.56 (0.56, 0.56) | 0.63 (0.62, 0.64) | 0.63 (0.6, 0.66) | 0.61 (0.61, 0.61) | 0.6 (0.58, 0.61) | NA (NA, NA) | 0.54 (0.51, 0.57) | 0.55 (0.53, 0.57) | 0.56 (0.52, 0.64) | 0.53 (0.52, 0.53) | ||
| r_prob | 0 (0, 0) | 0 (0, 0) | 0.08 (0.08, 0.08) | 0 (0, 0) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | 0 (0, 0) | 0 (0, 0) | 0.06 (0.06, 0.06) | 0.06 (0.06, 0.06) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | ||
| rate | 0 (0, 0.099) | 0 (0, 0) | 0.072 (0, 0.118) | 0 (0, 0) | 0 (0, 0.089) | 0 (0, 0.019) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0.077) | NA (NA, NA) | 0 (0, 0.024) | 0 (0, 0) | 0 (0, 0.052) | 0 (0, 0) | ||
| TP53- & AR- | Hormone_therapies | count | 291 | 291 | 291 | 291 | ||||||||||||
| time | 10 (7, 23) | 10 (7, 23) | 10 (7, 23) | 10 (7, 23) | ||||||||||||||
| n | 28 (20, 75) | 4 (2, 11) | 2 (0, 6) | 2 (0, 5) | ||||||||||||||
| post_p | 0.95 (0.82, 1) | 0.58 (0.51, 0.77) | 0.56 (0.51, 0.76) | 0.54 (0.51, 0.7) | ||||||||||||||
| r_prob | 0.44 (0.44, 0.44) | 0.35 (0.35, 0.35) | 0 (0, 0) | 0 (0, 0) | ||||||||||||||
| rate | 0.038 (0.018, 0.054) | 0 (0, 0.064) | 0 (0, 0.053) | 0 (0, 0.048) | ||||||||||||||
| Taxel_therapies | count | 1 | 1 | 1 | 1 | |||||||||||||
| time | 15 (15, 15) | 15 (15, 15) | 15 (15, 15) | 15 (15, 15) | ||||||||||||||
| n | 25 (25, 25) | 3 (3, 3) | 1 (1, 1) | 3 (3, 3) | ||||||||||||||
| post_p | 0.72 (0.72, 0.72) | 0.74 (0.74, 0.74) | 0.57 (0.57, 0.57) | 0.54 (0.54, 0.54) | ||||||||||||||
| r_prob | 0.11 (0.11, 0.11) | 0.29 (0.29, 0.29) | 0 (0, 0) | 0 (0, 0) | ||||||||||||||
| rate | 0.066 (0.066, 0.066) | 0.038 (0.038, 0.038) | 0 (0, 0) | 0 (0, 0) | ||||||||||||||
| Carboplatin | count | 1 | 1 | 1 | 1 | |||||||||||||
| time | 12 (12, 12) | 12 (12, 12) | 12 (12, 12) | 12 (12, 12) | ||||||||||||||
| n | 21 (21, 21) | 5 (5, 5) | 7 (7, 7) | 2 (2, 2) | ||||||||||||||
| post_p | 0.7 (0.7, 0.7) | 0.55 (0.55, 0.55) | 0.72 (0.72, 0.72) | 0.52 (0.52, 0.52) | ||||||||||||||
| r_prob | 0 (0, 0) | 0 (0, 0) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | ||||||||||||||
| rate | 0.09 (0.09, 0.09) | 0.077 (0.077, 0.077) | 0.057 (0.057, 0.057) | 0 (0, 0) | ||||||||||||||
| Niraparib | count | 1 | 1 | 1 | 1 | |||||||||||||
| time | 11 (11, 11) | 11 (11, 11) | 11 (11, 11) | 11 (11, 11) | ||||||||||||||
| n | 18 (18, 18) | 5 (5, 5) | 3 (3, 3) | 3 (3, 3) | ||||||||||||||
| post_p | 0.81 (0.81, 0.81) | 0.52 (0.52, 0.52) | 0.58 (0.58, 0.58) | 0.55 (0.55, 0.55) | ||||||||||||||
| r_prob | 0 (0, 0) | 0 (0, 0) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | ||||||||||||||
| rate | 0.041 (0.041, 0.041) | 0.096 (0.096, 0.096) | 0.04 (0.04, 0.04) | 0 (0, 0) | ||||||||||||||
| TP53+ | Hormone_therapies | count | 2 | 2 | 2 | 2 | 2 | 2 | 2 | 2 | ||||||||
| time | 11 (10, 12) | 11 (10, 12) | 11 (10, 12) | 11 (10, 12) | 11 (10, 12) | 11 (10, 12) | 11 (10, 12) | 11 (10, 12) | ||||||||||
| n | 17 (12, 22) | 4 (4, 5) | 0 (0, 1) | 0 (0, 0) | 2 (1, 4) | 3 (2, 4) | 0 (0, 1) | 2 (1, 2) | ||||||||||
| post_p | 0.84 (0.81, 0.88) | 0.7 (0.67, 0.74) | 0.54 (0.54, 0.54) | NA (NA, NA) | 0.76 (0.76, 0.76) | 0.53 (0.52, 0.54) | 0.5 (0.5, 0.5) | 0.54 (0.52, 0.57) | ||||||||||
| r_prob | 0.33 (0.33, 0.33) | 0.18 (0.18, 0.18) | 0 (0, 0) | 0 (0, 0) | 0.12 (0.12, 0.12) | 0.12 (0.12, 0.12) | 0 (0, 0) | 0 (0, 0) | ||||||||||
| rate | 0.069 (0.067, 0.072) | 0.054 (0.043, 0.065) | 0 (0, 0) | NA (NA, NA) | 0.036 (0.007, 0.065) | 0.06 (0.012, 0.108) | 0 (0, 0) | 0 (0, 0) | ||||||||||
| Taxel_therapies | count | 27 | 27 | 27 | 27 | 27 | 27 | 27 | 27 | |||||||||
| time | 10 (8, 15) | 10 (8, 15) | 10 (8, 15) | 10 (8, 15) | 10 (8, 15) | 10 (8, 15) | 10 (8, 15) | 10 (8, 15) | ||||||||||
| n | 9 (5, 14) | 11 (8, 18) | 0 (0, 2) | 1 (0, 4) | 3 (1, 5) | 4 (2, 6) | 0 (0, 2) | 1 (0, 3) | ||||||||||
| post_p | 0.75 (0.63, 0.84) | 0.77 (0.71, 0.97) | 0.53 (0.5, 0.6) | 0.56 (0.52, 0.65) | 0.54 (0.51, 0.68) | 0.64 (0.52, 0.8) | 0.54 (0.53, 0.59) | 0.53 (0.51, 0.6) | ||||||||||
| r_prob | 0.17 (0.17, 0.17) | 0.41 (0.41, 0.41) | 0 (0, 0) | 0 (0, 0) | 0.37 (0.37, 0.37) | 0.37 (0.37, 0.37) | 0 (0, 0) | 0 (0, 0) | ||||||||||
| rate | 0.089 (0.049, 0.135) | 0.026 (0.006, 0.053) | 0 (0, 0.114) | 0 (0, 0.012) | 0.096 (0, 0.204) | 0 (0, 0.094) | 0 (0, 0.064) | 0 (0, 0.108) | ||||||||||
| Carboplatin | count | 5 | 5 | 5 | 5 | 5 | 5 | 5 | 5 | |||||||||
| time | 16 (9, 19) | 16 (9, 19) | 16 (9, 19) | 16 (9, 19) | 16 (9, 19) | 16 (9, 19) | 16 (9, 19) | 16 (9, 19) | ||||||||||
| n | 11 (9, 20) | 4 (1, 5) | 5 (1, 11) | 4 (3, 5) | 4 (2, 4) | 0 (0, 2) | 3 (1, 4) | 2 (1, 4) | ||||||||||
| post_p | 0.86 (0.71, 0.9) | 0.52 (0.51, 0.59) | 0.69 (0.53, 0.82) | 0.57 (0.53, 0.67) | 0.56 (0.51, 0.71) | 0.53 (0.51, 0.54) | 0.55 (0.51, 0.62) | 0.59 (0.54, 0.6) | ||||||||||
| r_prob | 0.08 (0.08, 0.08) | 0 (0, 0) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | 0.06 (0.06, 0.06) | 0.06 (0.06, 0.06) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | ||||||||||
| rate | 0.07 (0.038, 0.092) | 0.098 (0, 0.134) | 0 (0, 0.033) | 0.029 (0.011, 0.037) | 0.105 (0.06, 0.2) | 0.134 (0.099, 0.169) | 0.033 (0.009, 0.066) | 0.026 (0, 0.053) | ||||||||||
| Niraparib | count | 8 | 8 | 8 | 8 | 8 | 8 | 8 | 8 | |||||||||
| time | 15 (9, 20) | 15 (9, 20) | 15 (9, 20) | 15 (9, 20) | 15 (9, 20) | 15 (9, 20) | 15 (9, 20) | 15 (9, 20) | ||||||||||
| n | 13 (9, 24) | 4 (2, 5) | 4 (1, 9) | 3 (1, 4) | 4 (3, 9) | 1 (0, 2) | 4 (2, 5) | 2 (1, 4) | ||||||||||
| post_p | 0.79 (0.75, 0.88) | 0.54 (0.52, 0.58) | 0.58 (0.51, 0.82) | 0.53 (0.51, 0.65) | 0.6 (0.51, 0.91) | 0.53 (0.52, 0.58) | 0.61 (0.51, 0.67) | 0.56 (0.53, 0.65) | ||||||||||
| r_prob | 0.08 (0.08, 0.08) | 0 (0, 0) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | 0.06 (0.06, 0.06) | 0.06 (0.06, 0.06) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | ||||||||||
| rate | 0.102 (0.047, 0.124) | 0.074 (0.026, 0.122) | 0 (0, 0.067) | 0.033 (0, 0.077) | 0.118 (0.088, 0.198) | 0 (0, 0.067) | 0.019 (0, 0.122) | 0 (0, 0.039) | ||||||||||
| DRD+ | Carboplatin | count | 89 | 89 | 89 | 89 | 89 | 89 | 89 | 89 | ||||||||
| time | 23 (13, 35) | 23 (13, 35) | 23 (13, 35) | 23 (13, 35) | 23 (13, 35) | 23 (13, 35) | 23 (13, 35) | 23 (13, 35) | ||||||||||
| n | 10 (4, 19) | 8 (3, 21) | 5 (2, 11) | 5 (2, 11) | 6 (2, 12) | 5 (3, 11) | 4 (2, 11) | 4 (2, 12) | ||||||||||
| post_p | 0.8 (0.56, 0.96) | 0.73 (0.52, 0.86) | 0.79 (0.55, 0.96) | 0.71 (0.53, 0.91) | 0.76 (0.54, 0.96) | 0.71 (0.55, 0.88) | 0.73 (0.54, 0.97) | 0.69 (0.52, 0.91) | ||||||||||
| r_prob | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | ||||||||||
| rate | 0.026 (0, 0.046) | 0.026 (0, 0.046) | 0.032 (0, 0.061) | 0.03 (0, 0.052) | 0.03 (0, 0.076) | 0.028 (0, 0.053) | 0.035 (0, 0.075) | 0.021 (0, 0.053) | ||||||||||
| Niraparib | count | 93 | 93 | 93 | 93 | 93 | 93 | 93 | 93 | |||||||||
| time | 25 (12, 34) | 25 (12, 34) | 25 (12, 34) | 25 (12, 34) | 25 (12, 34) | 25 (12, 34) | 25 (12, 34) | 25 (12, 34) | ||||||||||
| n | 9 (3, 17) | 10 (4, 17) | 5 (2, 13) | 5 (2, 11) | 5 (2, 11) | 5 (2, 12) | 5 (2, 11) | 5 (2, 11) | ||||||||||
| post_p | 0.78 (0.55, 0.92) | 0.73 (0.55, 0.88) | 0.77 (0.53, 0.98) | 0.71 (0.54, 0.86) | 0.78 (0.54, 0.95) | 0.71 (0.52, 0.95) | 0.78 (0.57, 0.95) | 0.69 (0.52, 0.91) | ||||||||||
| r_prob | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | ||||||||||
| rate | 0.032 (0, 0.057) | 0.025 (0, 0.043) | 0.031 (0, 0.071) | 0.023 (0, 0.062) | 0.033 (0, 0.067) | 0.025 (0, 0.06) | 0.028 (0, 0.069) | 0.019 (0, 0.06) | ||||||||||
| TEfus+ | Taxel_therapies | count | 166 | 166 | 166 | 166 | 166 | 166 | 166 | 166 | ||||||||
| time | 14 (9, 33) | 14 (9, 33) | 14 (9, 33) | 14 (9, 33) | 14 (9, 33) | 14 (9, 33) | 14 (9, 33) | 14 (9, 33) | ||||||||||
| n | 5 (2, 17) | 17 (11, 40) | 3 (1, 10) | 2 (0, 6) | 5 (3, 16) | 5 (2, 14) | 2 (0, 5) | 2 (0, 6) | ||||||||||
| post_p | 0.68 (0.52, 0.87) | 0.91 (0.75, 1) | 0.56 (0.51, 0.78) | 0.57 (0.51, 0.78) | 0.73 (0.53, 0.96) | 0.74 (0.55, 0.98) | 0.57 (0.51, 0.82) | 0.57 (0.51, 0.75) | ||||||||||
| r_prob | 0.29 (0.29, 0.29) | 0.41 (0.41, 0.41) | 0 (0, 0) | 0 (0, 0) | 0.41 (0.41, 0.41) | 0.37 (0.37, 0.37) | 0 (0, 0) | 0 (0, 0) | ||||||||||
| rate | 0.027 (0, 0.059) | 0.034 (0.014, 0.056) | 0 (0, 0.05) | 0 (0, 0.069) | 0.038 (0, 0.073) | 0.025 (0, 0.066) | 0 (0, 0.046) | 0 (0, 0.061) | ||||||||||
| Carboplatin | count | 2 | 2 | 2 | 2 | 2 | 2 | 2 | 2 | |||||||||
| time | 16 (10, 21) | 16 (10, 21) | 16 (10, 21) | 16 (10, 21) | 16 (10, 21) | 16 (10, 21) | 16 (10, 21) | 16 (10, 21) | ||||||||||
| n | 2 (0, 4) | 6 (4, 8) | 8 (6, 9) | 8 (3, 13) | 3 (2, 4) | 2 (1, 2) | 6 (4, 8) | 6 (4, 8) | ||||||||||
| post_p | 0.51 (0.51, 0.51) | 0.65 (0.54, 0.76) | 0.83 (0.75, 0.91) | 0.76 (0.6, 0.91) | 0.59 (0.55, 0.63) | 0.51 (0.51, 0.52) | 0.68 (0.59, 0.76) | 0.75 (0.67, 0.82) | ||||||||||
| r_prob | 0 (0, 0) | 0 (0, 0) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | 0 (0, 0) | 0.06 (0.06, 0.06) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | ||||||||||
| rate | 0 (0, 0) | 0.065 (0.049, 0.08) | 0.004 (0.001, 0.008) | 0.011 (0.002, 0.019) | 0.042 (0.008, 0.075) | 0.041 (0.008, 0.073) | 0 (0, 0) | 0.013 (0.003, 0.023) |
| signature | treatment | var | —- | —+ | –+- | –++ | -+– | -+-+ | -++- | -+++ | +— | +–+ | +-+- | +-++ | ++– | ++-+ | +++- | ++++ |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| all | Hormone_therapies | count | 4 | 4 | 4 | 4 | 4 | 4 | 4 | 4 | 4 | 4 | 4 | 4 | 4 | 4 | 4 | 4 |
| time | 4 (3, 6) | 4 (3, 6) | 4 (3, 6) | 4 (3, 6) | 4 (3, 6) | 4 (3, 6) | 4 (3, 6) | 4 (3, 6) | 4 (3, 6) | 4 (3, 6) | 4 (3, 6) | 4 (3, 6) | 4 (3, 6) | 4 (3, 6) | 4 (3, 6) | 4 (3, 6) | ||
| n | 12 (9, 16) | 2 (1, 5) | 12 (8, 13) | 2 (0, 5) | 0 (0, 3) | 0 (0, 0) | 0 (0, 0) | 0 (0, 1) | 0 (0, 3) | 0 (0, 2) | 0 (0, 1) | 0 (0, 1) | 0 (0, 0) | 0 (0, 0) | 0 (0, 1) | 0 (0, 1) | ||
| post_p | 0.35 (0.33, 0.45) | 0.42 (0.39, 0.44) | 0.36 (0.31, 0.4) | 0.3 (0.25, 0.41) | 0.43 (0.43, 0.43) | NA (NA, NA) | NA (NA, NA) | 0.44 (0.44, 0.44) | 0.42 (0.42, 0.42) | 0.41 (0.41, 0.42) | 0.43 (0.41, 0.44) | 0.48 (0.48, 0.48) | NA (NA, NA) | NA (NA, NA) | 0.43 (0.43, 0.43) | 0.44 (0.44, 0.44) | ||
| r_prob | 0.44 (0.44, 0.44) | 0.35 (0.35, 0.35) | 0.33 (0.33, 0.33) | 0.18 (0.18, 0.18) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0.18 (0.18, 0.18) | 0.18 (0.18, 0.18) | 0.12 (0.12, 0.12) | 0.12 (0.12, 0.12) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | ||
| rate | 0.126 (0.113, 0.155) | 0.19 (0.032, 0.284) | 0.203 (0.157, 0.256) | 0.408 (0.277, 1.764) | 0.132 (0.132, 0.132) | NA (NA, NA) | NA (NA, NA) | 0.733 (0.733, 0.733) | 0.185 (0.185, 0.185) | 0.931 (0.346, 1.517) | 0.408 (0.36, 0.456) | 0.597 (0.119, 1.074) | NA (NA, NA) | NA (NA, NA) | 42.436 (42.436, 42.436) | 0.409 (0.409, 0.409) | ||
| Niraparib | count | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | |
| time | 12 (12, 12) | 12 (12, 12) | 12 (12, 12) | 12 (12, 12) | 12 (12, 12) | 12 (12, 12) | 12 (12, 12) | 12 (12, 12) | 12 (12, 12) | 12 (12, 12) | 12 (12, 12) | 12 (12, 12) | 12 (12, 12) | 12 (12, 12) | 12 (12, 12) | 12 (12, 12) | ||
| n | 4 (4, 4) | 1 (1, 1) | 10 (10, 10) | 2 (2, 2) | 3 (3, 3) | 2 (2, 2) | 4 (4, 4) | 6 (6, 6) | 4 (4, 4) | 3 (3, 3) | 3 (3, 3) | 6 (6, 6) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 3 (3, 3) | ||
| post_p | 0.2 (0.2, 0.2) | 0.36 (0.36, 0.36) | 0.14 (0.14, 0.14) | 0.49 (0.49, 0.49) | 0.36 (0.36, 0.36) | 0.35 (0.35, 0.35) | 0.37 (0.37, 0.37) | 0.45 (0.45, 0.45) | 0.37 (0.37, 0.37) | 0.4 (0.4, 0.4) | 0.39 (0.39, 0.39) | 0.48 (0.48, 0.48) | NA (NA, NA) | NA (NA, NA) | NA (NA, NA) | 0.49 (0.49, 0.49) | ||
| r_prob | 0 (0, 0) | 0 (0, 0) | 0.08 (0.08, 0.08) | 0 (0, 0) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | 0 (0, 0) | 0 (0, 0) | 0.06 (0.06, 0.06) | 0.06 (0.06, 0.06) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | ||
| rate | 0.289 (0.289, 0.289) | 0.24 (0.24, 0.24) | 0.246 (0.246, 0.246) | 0.1 (0.1, 0.1) | 0.087 (0.087, 0.087) | 0.361 (0.361, 0.361) | 0.13 (0.13, 0.13) | 0.072 (0.072, 0.072) | 0.209 (0.209, 0.209) | 0.162 (0.162, 0.162) | 0.214 (0.214, 0.214) | 0.087 (0.087, 0.087) | NA (NA, NA) | NA (NA, NA) | NA (NA, NA) | 0.06 (0.06, 0.06) | ||
| TP53- & AR- | Hormone_therapies | count | 1 | 1 | 1 | 1 | ||||||||||||
| time | 13 (13, 13) | 13 (13, 13) | 13 (13, 13) | 13 (13, 13) | ||||||||||||||
| n | 41 (41, 41) | 5 (5, 5) | 0 (0, 0) | 0 (0, 0) | ||||||||||||||
| post_p | 0.42 (0.42, 0.42) | 0.2 (0.2, 0.2) | NA (NA, NA) | NA (NA, NA) | ||||||||||||||
| r_prob | 0.44 (0.44, 0.44) | 0.35 (0.35, 0.35) | 0 (0, 0) | 0 (0, 0) | ||||||||||||||
| rate | 0.079 (0.079, 0.079) | 0.128 (0.128, 0.128) | NA (NA, NA) | NA (NA, NA) | ||||||||||||||
| Taxel_therapies | count | 84 | 84 | 84 | 84 | |||||||||||||
| time | 22 (13, 32) | 22 (13, 32) | 22 (13, 32) | 22 (13, 32) | ||||||||||||||
| n | 13 (8, 30) | 6 (2, 12) | 3 (2, 7) | 5 (1, 9) | ||||||||||||||
| post_p | 0.1 (0.02, 0.31) | 0.43 (0.29, 0.49) | 0.26 (0.14, 0.44) | 0.42 (0.25, 0.49) | ||||||||||||||
| r_prob | 0.11 (0.11, 0.11) | 0.29 (0.29, 0.29) | 0 (0, 0) | 0 (0, 0) | ||||||||||||||
| rate | 0.164 (0.113, 0.268) | 0.075 (0.051, 0.162) | 0.205 (0.094, 0.653) | 0.066 (0.038, 0.152) | ||||||||||||||
| Carboplatin | count | 71 | 71 | 71 | 71 | |||||||||||||
| time | 17 (11, 28) | 17 (11, 28) | 17 (11, 28) | 17 (11, 28) | ||||||||||||||
| n | 13 (7, 27) | 4 (2, 9) | 6 (2, 9) | 6 (3, 11) | ||||||||||||||
| post_p | 0.11 (0.02, 0.32) | 0.31 (0.09, 0.43) | 0.45 (0.27, 0.49) | 0.44 (0.29, 0.49) | ||||||||||||||
| r_prob | 0 (0, 0) | 0 (0, 0) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | ||||||||||||||
| rate | 0.166 (0.118, 0.328) | 0.2 (0.104, 0.483) | 0.072 (0.046, 0.257) | 0.051 (0.029, 0.085) | ||||||||||||||
| Niraparib | count | 79 | 79 | 79 | 79 | |||||||||||||
| time | 17 (14, 25) | 17 (14, 25) | 17 (14, 25) | 17 (14, 25) | ||||||||||||||
| n | 15 (9, 37) | 4 (2, 7) | 5 (2, 11) | 6 (3, 11) | ||||||||||||||
| post_p | 0.13 (0.02, 0.33) | 0.32 (0.12, 0.44) | 0.45 (0.34, 0.49) | 0.44 (0.26, 0.49) | ||||||||||||||
| r_prob | 0 (0, 0) | 0 (0, 0) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | ||||||||||||||
| rate | 0.158 (0.115, 0.244) | 0.173 (0.086, 0.598) | 0.076 (0.046, 0.185) | 0.06 (0.032, 0.126) | ||||||||||||||
| TP53+ | Hormone_therapies | count | 256 | 256 | 256 | 256 | 256 | 256 | 256 | 256 | ||||||||
| time | 22 (13, 32) | 22 (13, 32) | 22 (13, 32) | 22 (13, 32) | 22 (13, 32) | 22 (13, 32) | 22 (13, 32) | 22 (13, 32) | ||||||||||
| n | 14 (7, 36) | 6 (4, 14) | 2 (1, 5) | 2 (1, 5) | 4 (1, 10) | 3 (2, 7) | 3 (1, 5) | 2 (1, 5) | ||||||||||
| post_p | 0.3 (0.08, 0.47) | 0.23 (0.08, 0.42) | 0.38 (0.23, 0.48) | 0.37 (0.2, 0.46) | 0.39 (0.23, 0.47) | 0.36 (0.16, 0.47) | 0.38 (0.21, 0.47) | 0.36 (0.2, 0.46) | ||||||||||
| r_prob | 0.33 (0.33, 0.33) | 0.18 (0.18, 0.18) | 0 (0, 0) | 0 (0, 0) | 0.12 (0.12, 0.12) | 0.12 (0.12, 0.12) | 0 (0, 0) | 0 (0, 0) | ||||||||||
| rate | 0.184 (0.141, 0.293) | 0.159 (0.106, 0.305) | 0.2 (0.099, 0.713) | 0.191 (0.084, 0.717) | 0.22 (0.136, 0.548) | 0.193 (0.108, 0.47) | 0.215 (0.097, 0.645) | 0.19 (0.082, 0.616) | ||||||||||
| Taxel_therapies | count | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | |||||||||
| time | 10 (10, 10) | 10 (10, 10) | 10 (10, 10) | 10 (10, 10) | 10 (10, 10) | 10 (10, 10) | 10 (10, 10) | 10 (10, 10) | ||||||||||
| n | 11 (11, 11) | 15 (15, 15) | 0 (0, 0) | 1 (1, 1) | 4 (4, 4) | 3 (3, 3) | 0 (0, 0) | 0 (0, 0) | ||||||||||
| post_p | 0.41 (0.41, 0.41) | 0.32 (0.32, 0.32) | NA (NA, NA) | 0.49 (0.49, 0.49) | 0.44 (0.44, 0.44) | 0.5 (0.5, 0.5) | NA (NA, NA) | NA (NA, NA) | ||||||||||
| r_prob | 0.17 (0.17, 0.17) | 0.41 (0.41, 0.41) | 0 (0, 0) | 0 (0, 0) | 0.37 (0.37, 0.37) | 0.37 (0.37, 0.37) | 0 (0, 0) | 0 (0, 0) | ||||||||||
| rate | 0.148 (0.148, 0.148) | 0.08 (0.08, 0.08) | NA (NA, NA) | 0 (0, 0) | 0.17 (0.17, 0.17) | 0.123 (0.123, 0.123) | NA (NA, NA) | NA (NA, NA) | ||||||||||
| Niraparib | count | 3 | 3 | 3 | 3 | 3 | 3 | 3 | 3 | |||||||||
| time | 14 (12, 17) | 14 (12, 17) | 14 (12, 17) | 14 (12, 17) | 14 (12, 17) | 14 (12, 17) | 14 (12, 17) | 14 (12, 17) | ||||||||||
| n | 9 (8, 10) | 3 (2, 4) | 1 (1, 3) | 1 (0, 5) | 4 (3, 7) | 6 (3, 8) | 0 (0, 2) | 3 (3, 3) | ||||||||||
| post_p | 0.14 (0.14, 0.38) | 0.28 (0.18, 0.45) | 0.4 (0.37, 0.44) | 0.47 (0.45, 0.49) | 0.39 (0.39, 0.42) | 0.33 (0.29, 0.45) | 0.42 (0.42, 0.42) | 0.44 (0.34, 0.48) | ||||||||||
| r_prob | 0.08 (0.08, 0.08) | 0 (0, 0) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | 0.06 (0.06, 0.06) | 0.06 (0.06, 0.06) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | ||||||||||
| rate | 0.246 (0.203, 0.306) | 0.198 (0.119, 0.311) | 0.376 (0.18, 0.466) | 0.036 (0.007, 0.065) | 0.223 (0.216, 0.282) | 0.087 (0.082, 1.361) | 0.077 (0.077, 0.077) | 0.06 (0.034, 0.14) | ||||||||||
| DRD+ | Hormone_therapies | count | 51 | 51 | 51 | 51 | 51 | 51 | 51 | 51 | ||||||||
| time | 28 (21, 34) | 28 (21, 34) | 28 (21, 34) | 28 (21, 34) | 28 (21, 34) | 28 (21, 34) | 28 (21, 34) | 28 (21, 34) | ||||||||||
| n | 4 (0, 9) | 4 (0, 11) | 3 (1, 5) | 3 (1, 5) | 3 (1, 7) | 3 (2, 7) | 3 (1, 7) | 3 (1, 6) | ||||||||||
| post_p | 0.41 (0.26, 0.48) | 0.39 (0.26, 0.48) | 0.31 (0.19, 0.43) | 0.32 (0.16, 0.46) | 0.34 (0.2, 0.46) | 0.29 (0.17, 0.46) | 0.38 (0.24, 0.48) | 0.31 (0.14, 0.44) | ||||||||||
| r_prob | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | ||||||||||
| rate | 0.088 (0.051, 0.163) | 0.066 (0.046, 0.157) | 0.206 (0.122, 0.619) | 0.19 (0.079, 0.854) | 0.21 (0.107, 0.6) | 0.16 (0.084, 0.448) | 0.18 (0.091, 0.767) | 0.17 (0.087, 0.579) | ||||||||||
| Taxel_therapies | count | 8 | 8 | 8 | 8 | 8 | 8 | 8 | 8 | |||||||||
| time | 26 (20, 33) | 26 (20, 33) | 26 (20, 33) | 26 (20, 33) | 26 (20, 33) | 26 (20, 33) | 26 (20, 33) | 26 (20, 33) | ||||||||||
| n | 4 (3, 12) | 6 (4, 8) | 4 (2, 6) | 2 (1, 6) | 2 (1, 5) | 3 (1, 7) | 2 (2, 5) | 4 (0, 8) | ||||||||||
| post_p | 0.27 (0.12, 0.39) | 0.36 (0.25, 0.41) | 0.3 (0.18, 0.4) | 0.46 (0.27, 0.48) | 0.33 (0.29, 0.43) | 0.37 (0.36, 0.45) | 0.37 (0.27, 0.47) | 0.41 (0.38, 0.48) | ||||||||||
| r_prob | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | ||||||||||
| rate | 0.154 (0.106, 0.185) | 0.069 (0.052, 0.105) | 0.218 (0.142, 1.413) | 0.124 (0.057, 0.261) | 0.233 (0.144, 0.887) | 0.097 (0.057, 0.185) | 0.245 (0.109, 3.523) | 0.078 (0.061, 0.15) | ||||||||||
| Carboplatin | count | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | |||||||||
| time | 14 (14, 14) | 14 (14, 14) | 14 (14, 14) | 14 (14, 14) | 14 (14, 14) | 14 (14, 14) | 14 (14, 14) | 14 (14, 14) | ||||||||||
| n | 8 (8, 8) | 4 (4, 4) | 5 (5, 5) | 2 (2, 2) | 4 (4, 4) | 0 (0, 0) | 1 (1, 1) | 2 (2, 2) | ||||||||||
| post_p | 0.38 (0.38, 0.38) | 0.38 (0.38, 0.38) | 0.32 (0.32, 0.32) | 0.38 (0.38, 0.38) | 0.44 (0.44, 0.44) | NA (NA, NA) | 0.48 (0.48, 0.48) | 0.46 (0.46, 0.46) | ||||||||||
| r_prob | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | ||||||||||
| rate | 0.074 (0.074, 0.074) | 0.143 (0.143, 0.143) | 0.104 (0.104, 0.104) | 0.152 (0.152, 0.152) | 0.119 (0.119, 0.119) | NA (NA, NA) | 0.107 (0.107, 0.107) | 0.068 (0.068, 0.068) | ||||||||||
| TEfus+ | Hormone_therapies | count | 112 | 112 | 112 | 112 | 112 | 112 | 112 | 112 | ||||||||
| time | 22 (15, 32) | 22 (15, 32) | 22 (15, 32) | 22 (15, 32) | 22 (15, 32) | 22 (15, 32) | 22 (15, 32) | 22 (15, 32) | ||||||||||
| n | 5 (2, 13) | 7 (4, 15) | 4 (0, 9) | 2 (1, 5) | 3 (2, 8) | 3 (2, 6) | 3 (1, 5) | 3 (1, 5) | ||||||||||
| post_p | 0.43 (0.27, 0.49) | 0.21 (0.07, 0.41) | 0.42 (0.28, 0.48) | 0.37 (0.23, 0.47) | 0.33 (0.16, 0.43) | 0.33 (0.14, 0.47) | 0.37 (0.18, 0.47) | 0.36 (0.21, 0.46) | ||||||||||
| r_prob | 0.35 (0.35, 0.35) | 0.18 (0.18, 0.18) | 0 (0, 0) | 0 (0, 0) | 0.18 (0.18, 0.18) | 0.12 (0.12, 0.12) | 0 (0, 0) | 0 (0, 0) | ||||||||||
| rate | 0.073 (0.045, 0.173) | 0.168 (0.113, 0.377) | 0.068 (0.042, 0.157) | 0.148 (0.074, 0.589) | 0.215 (0.113, 0.63) | 0.177 (0.111, 0.443) | 0.177 (0.067, 0.549) | 0.177 (0.083, 0.672) | ||||||||||
| Carboplatin | count | 8 | 8 | 8 | 8 | 8 | 8 | 8 | 8 | |||||||||
| time | 18 (12, 29) | 18 (12, 29) | 18 (12, 29) | 18 (12, 29) | 18 (12, 29) | 18 (12, 29) | 18 (12, 29) | 18 (12, 29) | ||||||||||
| n | 6 (3, 8) | 8 (5, 9) | 6 (5, 8) | 4 (1, 6) | 2 (1, 5) | 3 (2, 5) | 2 (1, 6) | 4 (2, 6) | ||||||||||
| post_p | 0.25 (0.08, 0.4) | 0.29 (0.13, 0.39) | 0.43 (0.32, 0.48) | 0.45 (0.35, 0.48) | 0.34 (0.27, 0.43) | 0.37 (0.21, 0.49) | 0.39 (0.29, 0.47) | 0.43 (0.34, 0.47) | ||||||||||
| r_prob | 0 (0, 0) | 0 (0, 0) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | 0 (0, 0) | 0.06 (0.06, 0.06) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | ||||||||||
| rate | 0.276 (0.108, 0.339) | 0.146 (0.13, 0.325) | 0.051 (0.043, 0.076) | 0.062 (0.048, 0.132) | 0.309 (0.157, 0.441) | 0.191 (0.123, 0.349) | 0.071 (0.027, 0.233) | 0.069 (0.051, 0.3) | ||||||||||
| Niraparib | count | 8 | 8 | 8 | 8 | 8 | 8 | 8 | 8 | |||||||||
| time | 14 (11, 24) | 14 (11, 24) | 14 (11, 24) | 14 (11, 24) | 14 (11, 24) | 14 (11, 24) | 14 (11, 24) | 14 (11, 24) | ||||||||||
| n | 3 (2, 4) | 7 (4, 12) | 7 (4, 11) | 4 (2, 6) | 2 (1, 5) | 4 (3, 5) | 2 (1, 6) | 2 (2, 4) | ||||||||||
| post_p | 0.38 (0.28, 0.47) | 0.21 (0.13, 0.42) | 0.43 (0.4, 0.48) | 0.48 (0.41, 0.49) | 0.42 (0.3, 0.47) | 0.43 (0.31, 0.46) | 0.44 (0.33, 0.48) | 0.43 (0.34, 0.48) | ||||||||||
| r_prob | 0 (0, 0) | 0 (0, 0) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | 0 (0, 0) | 0.06 (0.06, 0.06) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | ||||||||||
| rate | 0.163 (0.103, 0.222) | 0.172 (0.118, 0.371) | 0.042 (0.036, 0.077) | 0.072 (0.019, 0.086) | 0.223 (0.131, 1.554) | 0.125 (0.091, 0.239) | 0.077 (0.028, 0.271) | 0.122 (0.055, 0.319) |